Correction to: Calycosin suppresses TGF-β-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells

Wang, Qun; Lu, Weijun; Yin, Tao; Lu, Li

doi:10.1186/s13046-019-1298-5

Cited by 4 publications

(4 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TGF-β is involved in regulating the biological function of malignant tumors through several pathways, including the Jagged1/Notch, Wnt, JAK2/STAT3, and PI3K/AKT/mTOR signaling pathways [13][14][15][16]. Moreover, regulation of Akt/ mTOR pathway activity can inhibit osteosarcoma cell proliferation, arrest the cell cycle, induce apoptosis, and suppress invasion and metastasis, suggesting the involvement of this pathway in the development of osteosarcoma [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: TGF-β is associated with poor prognosis and promotes osteosarcoma progression via PI3K/Akt pathway activation

Zhang

2020

Cell Cycle

View full text Add to dashboard Cite

Transforming growth factor beta (TGF-β) is a multifunctional cytokine with important functions in cell proliferation and differentiation. TGF-β is highly expressed in several types of cancers and promotes tumor invasion and metastasis. However, the role of TGF-β in osteosarcoma progression is poorly understood. In the present study, we found that TGF-β is highly expressed in osteosarcoma cells and tissues, and is associated with high Ennecking stage (P = 0.033), metastasis, and recurrence. TGF-β-knockdown osteosarcoma cell lines were established using siRNA (si-TGF-β). Cells transfected with si-TGF-β exhibited significantly reduced proliferation, migration/invasion, and colony formation abilities, and increased levels of cell apoptosis. In addition, si-TGF-β treatment reduced spheroid size, the ratio of CD133-positive cells, and expression of SOX-2, Nanog, and Oct-3/4 in osteosarcoma cells. Mechanistically, PI3K/mTOR phosphorylation is inhibited by TGF-β knockdown. Pretreatment with 25 µM LY294002, a PI3K-specific inhibitor, further enhanced the si-TGF-β-induced suppression of osteosarcoma progression. Taken together, these results reveal a novel role for TGF-β in osteosarcoma progression and modulation of stemness-related traits and indicate that TGF-β may be of value as a therapeutic target for the treatment of osteosarcoma.

show abstract

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: TGF-β is associated with poor prognosis and promotes osteosarcoma progression via PI3K/Akt pathway activation

Zhang

2020

Cell Cycle

View full text Add to dashboard Cite

show abstract

“…However, cotreatment of HT-29 with IGF-1 could recover calycosin-induced cell autophagy. Wang found that calycosin inhibited colorectal cancer proliferation and migration by enhancing BATF2 to target plasminogen activator inhibitor-1 [ 27 ]. Moreover, this molecule was able to abolish transforming growth factor ß - (TGF- β -) induced epithelial-to-mesenchymal transition via altering Wnt mechanism [ 27 ].…”

Section: Pharmacological Activities Of Calycosinmentioning

confidence: 99%

“…Wang found that calycosin inhibited colorectal cancer proliferation and migration by enhancing BATF2 to target plasminogen activator inhibitor-1 [ 27 ]. Moreover, this molecule was able to abolish transforming growth factor ß - (TGF- β -) induced epithelial-to-mesenchymal transition via altering Wnt mechanism [ 27 ]. In addition, calycosin robustly restricted HCT-116 cells viability and invasiveness by enhancing ER β and phosphatase and tensin homolog (PTEN) expressions [ 28 ].…”

Section: Pharmacological Activities Of Calycosinmentioning

confidence: 99%

Pharmaceutical Values of Calycosin: One Type of Flavonoid Isolated from Astragalus

Gong

Zheng

Yang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Astragalus is a popular Materia Medica in China, and it could be applied in the treatment of various diseases. It contains a variety of chemically active ingredients, such as saponins, flavonoids, and polysaccharides. Plant-derived bioactive chemicals are considered natural, safe, and beneficial. Among the infinite plant-identified and isolated molecules, flavonoids have been reported to have positive effects on human health. Calycosin is the most important active flavonoid substance identified predominantly within this medicinal plant. In recent years, calycosin has been reported to have anticancer, antioxidative, immune-modulatory, and estrogenic-like properties. This review collected recent relevant literatures on calycosin and summarized its potential pharmaceutical properties and working mechanism involved, which provided solid basis for future clinical research.

show abstract

“…Another cytokine, transforming growth factor -beta (TGF-β), a superfamily regulates tissue regeneration can also induce epithelial-mesenchymal transition (EMT) [12,13]. TGF-β might increase the levels of PAI-1 [14,15]. Therefore, we designed the prospected study including testing PAI-1, t-PA, TGF-β and Interferon-gamma (IFN-γ) in pleural effusion then observing the pleural changes during the chemotherapy, trying to find out the underlying predictive risk factors of PTM occurrence.…”

Section: Introductionmentioning

confidence: 99%

Predictive Risk Factors of Pleural Tuberculoma Occurrence on Patients with Pleural Tuberculosis

Dong¹,

Zhang²,

Wu³

et al. 2019

Preprint

View full text Add to dashboard Cite

Background: Pleural tuberculoma (PTM) had been observed more and more frequently on patients with pleural tuberculosis (PT). The occurrence of PTM is not favorable for the treatment outcome of PT. However, its predictive risk factors had not been clarified. This study was to explore the predictive risk factors of PTM occurrence on the patients with PT. Methods: From January 2017 to June 2018, patients diagnosed as PT were enrolled prospectively into the study. All clinical characteristics and pleural changes during the chemotherapy were recorded and adenosine aminase (ADA)、 lactate dehydrogenase (LDH)、glucose and protein of pleural fluid were quantified. Interferon-gamma (IFN- γ)、 transforming growth factor -beta (TGF-β), plasminogen activator inhibitor type-1 (PAI-1) and tissue plasminogen activator (t-PA) of pleural fluid were tested before chemotherapy by enzyme-linked immunosorbent assay (ELISA). Results: A total of 162 patients with PT were enrolled. 82 patients (51.3%, 82/162) developed PTM during chemotherapy. We found the probability of PT to develop PTM reached 99.5% when the patients with pleural thickness, packaged plural effusion, LDH>461.5 IU/L , ADA>62.9 IU/L , GLU<4.75 mmol/L and age>32.5 years old. The probability to develop PTM was as low as 1.4% when these 6 indices were in the opposite trend to the conditions list above. Using tested cytokines in pleural fluid from 76 cases, the probability of PTM if patients satisfied 3 indexes including increased TGF-β(>15.235 μ g/L) , increased PAI-1(>180.720 μ g/L) and decreased t-PA(<2.875 μ g/L ) was 78%, and the probability to develop PTM was only as low as 2.7% when these 3 cytokines were in the opposite trend. Conclusions: Age, pleural thickness, packaged pleural fluid, increased ADA, LDH, TGF-β, PAI-1 and decreased glucose and t-PA might be predictive risk factors of developing PTM for patients with PT, clinicians should take deep consideration if patients had above factors.

show abstract

Correction to: Calycosin suppresses TGF-β-induced epithelial-to-mesenchymal transition and migration by upregulating BATF2 to target PAI-1 via the Wnt and PI3K/Akt signaling pathways in colorectal cancer cells

Cited by 4 publications

References 1 publication

RETRACTED ARTICLE: TGF-β is associated with poor prognosis and promotes osteosarcoma progression via PI3K/Akt pathway activation

RETRACTED ARTICLE: TGF-β is associated with poor prognosis and promotes osteosarcoma progression via PI3K/Akt pathway activation

Pharmaceutical Values of Calycosin: One Type of Flavonoid Isolated from Astragalus

Predictive Risk Factors of Pleural Tuberculoma Occurrence on Patients with Pleural Tuberculosis

Contact Info

Product

Resources

About