Correction to Cell-Selective Biological Activity of Rhodium Metalloinsertors Correlates with Subcellular Localization

Regulating Bioactivity of Cu2+ Bis-1,10-phenanthroline Artificial Metallonucleases with Sterically Functionalized Pendant Carboxylates

“…Small copper–phenanthroline molecules with DNA and RNA recognition properties represent important chemotypes capable of abrogating nucleic acid sequences through metal-driven oxidative cleavage. , The chemical nuclease, [Cu(1,10-phen) 2 ] 2+ , is a well studied reagent which randomly cleaves nucleic acids in the presence of molecular oxygen (or hydrogen peroxide) upon reduction to Cu + . − This agent oxidizes duplex DNA (dsDNA) without specificity, predominantly at the minor groove with C–H bonds at C1′, C4′, and C5′, being the main targets of abstraction . Arising from this application, the attachment, or tethering, of 1,10-phen to DNA targeting agents, proteins and single-stranded nucleic acid vectors have successfully delivered sequence-specific scission upon incubation with Cu 2+ ions in a reducing chemical environment. − Furthermore, this complex may also have application as a chemical protease with the oxidative degradation of peptide bonds having already been reported. , While the intracellular metal-chelating ligand, 1,10-phen, is known to elicit excellent in vitro antifungal, , antibacterial, and anticancer activities alone, or as part of a metal complex, − recent interest has focused on the modification of this ligand to afford phenazine-type structures of extended π-symmetry for use within metal DNA-binding probes, , some with selective chemotherapeutic utility …”