Correction to: Periodontitis and Rheumatoid Arthritis: The Common Thread

Jajoo, Namrata S.; Shelke, Anup U; Bajaj, Rajat; Devani, Vivek R.

doi:10.1007/s12018-021-09280-z

Cited by 3 publications

(1 citation statement)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the early twentieth century, researchers explored the potential association between inadequate dental health and RA, observing improved symptoms of RA in patients with dental health issues after undergoing periodontal infection therapy [ 26 , 27 ]. It becomes apparent that RA progression is influenced by oral microbiota which poor oral health is one of its causing factors [ 28 ].…”

Section: Introductionmentioning

confidence: 99%

Distinct oral DNA viral signatures in rheumatoid arthritis: a Pilot study

Ghorbani,

Khoshdoozmasouleh

2024

Journal of Oral Microbiology

View full text Add to dashboard Cite

Background Despite evidence linking viruses and oral microbiome to rheumatoid arthritis (RA), limited whole genome sequencing research has been conducted on the oral virome (a viral component of the microbiome) of untreated RA patients. This pilot research seeks to address this knowledge gap by comparing the oral virome of untreated rheumatoid arthritis patients (RAs) and healthy individuals (HCs). Method Whole genome DNA sequence of saliva samples from 45 participants including 21 RAs and 24 age and gender matched HCs was obtained from the BioProject: PRJEB6997. Metaphlan3 pipeline and LEfSe analysis were used for the viral signature detection. Wilcoxon pairwise test and ROC analysis were used to validate and predict signatures. Results RA exhibits higher alpha diversity compared to HCs. Callitrichine gammaherpesvirus 3, Human gammaherpesvirus 4 (EBV), Murid betaherpesvirus 8, and Suid alphaherpesvirus 1 were enriched in RAs, while Aotine betaherpesvirus 1 from the Cytomegalovirus genus was enriched in HCs. In addition, Saccharomyces cerevisiae killer virus M1 (ScV-M1) was found to be enriched in RAs, whereas bacteriophage Hk97virus (Siphoviridae) and Cd119virus (Myoviridae) were enriched in HCs. Conclusion This study identifies significant DNA oral viral signatures at species level as potential biomarkers for the early detection and diagnosis of rheumatoid arthritis.

show abstract

Section: Introductionmentioning

confidence: 99%

Distinct oral DNA viral signatures in rheumatoid arthritis: a Pilot study

Ghorbani,

Khoshdoozmasouleh

2024

Journal of Oral Microbiology

View full text Add to dashboard Cite

show abstract

A closer look at the link between rheumatoid arthritis and periodontal disease

Sharma,

Thind,

Goyal

et al. 2024

IJCAP

View full text Add to dashboard Cite

Rheumatoid arthritis (RA) and periodontal diseases (PD) are chronic inflammatory conditions that share a complex and bidirectional relationship. Both conditions exhibit common pathogenic mechanisms, including chronic inflammation, immune system dysregulation, and tissue destruction, suggesting a potential close association. This abstract aims to highlight the emerging evidence on the correlation between RA and PD, focusing on their shared risk factors, underlying biological pathways, and the implications for patient management.Studies have shown that individuals with RA are more likely to suffer from periodontal diseases, particularly periodontitis, which is characterized by the progressive destruction of the supporting structures of teeth. The presence of periodontal pathogens, notably Porphyromonas gingivalis, has been implicated in the citrullination of proteins—a key process in the development of RA autoantibodies, specifically anti-citrullinated protein antibodies (ACPAs). These antibodies play a central role in RA pathogenesis, indicating a potential triggering link between periodontal infection and RA onset.Furthermore, systemic inflammation present in RA exacerbates periodontal inflammation and vice versa, creating a vicious cycle. The shared inflammatory mediators, including cytokines such as TNF-α, IL-1, and IL-6, further reinforce the connection between the two conditions. Management of PD has shown to improve clinical outcomes in RA patients, suggesting that periodontal health may influence RA disease activity.The close association between rheumatoid arthritis and periodontal diseases highlights the need for an integrated approach to diagnosis and treatment. Recognizing and managing periodontal disease in RA patients may reduce systemic inflammation and improve overall disease outcomes. Future research should focus on exploring the molecular links between RA and PD, as well as the potential benefits of combined therapeutic interventions.

show abstract

Activity of Phosphatases in the Oral Liquid of Patients From Polluted Areas Who Are Diagnosed With Generalized Periodontitis and Rheumatoid Arthritis

Kovalyshyn,

Popovych,

Chubij

et al. 2023

Wiad Lek

View full text Add to dashboard Cite

The aim: To study the activity of acid and alkaline phosphatases as markers of bone metabolism in patients from bad environmental areas who are diagnosed with rheumatoid arthritis and are affected by generalized periodontitis. Materials and methods: A total of 137 residents from Kalush district of the Ivano-Frankivsk region, Ukraine were enrolled in this investigation. There were 105 patients aged between 18 and 60 years with generalized periodontitis of the I-II degree severity selected for further research. Among them were 70 patients diagnosed with rheumatoid arthritis at the stage of remission. The research comprised the study of oral fluid of the examined individuals in order to assess the bone metabolism based on activity of the acid and alkaline phosphatases. Results: The results of the conducted studies testify an increase of acid phosphatase in subgroups of patients diagnosed with rheumatoid arthritis and affected by generalized chronic periodontitis. On the other hand, the obtained results of alkaline phosphatase activity demonstrated a decrease of this indicator in all subgroups. Conclusions: The results of biochemical studies suggest that there is a significant violation of bone tissue metabolism observed in patients from environmentally unfavorable areas affected by generalized periodontitis and diagnosed with rheumatoid arthritis.

show abstract

Correction to: Periodontitis and Rheumatoid Arthritis: The Common Thread

Cited by 3 publications

References 84 publications

Distinct oral DNA viral signatures in rheumatoid arthritis: a Pilot study

Distinct oral DNA viral signatures in rheumatoid arthritis: a Pilot study

A closer look at the link between rheumatoid arthritis and periodontal disease

Activity of Phosphatases in the Oral Liquid of Patients From Polluted Areas Who Are Diagnosed With Generalized Periodontitis and Rheumatoid Arthritis

Contact Info

Product

Resources

About