Correction to: Phenotypic characteristics and prognosis of inpatients with COVID-19 and diabetes: the CORONADO study

Abstract

The authors regret a mistake in Table 1. Contrary to the statement in footnote a (applicable to age, BMI and HbA 1c), only BMI was standardised and thus the OR for HbA 1c and age is expressed per 1 unit, not 1 SD. The table and footnote are corrected here.

Comment on Chen et al. Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering Medication. Diabetes Care 2020;43:1399–1407

“…However, this probably reflects their advanced stage of diabetes with frequent comorbidities contraindicating the use of other glucose-lowering therapies. In agreement with this hypothesis, insulin therapy was not associated with death on D7 in multivariable analyses in CORONADO ( 3 ).…”

“…Therefore, as highlighted by Riddle et al ( 1 ), specific data providing a better understanding of the relationship between diabetes and COVID-19 are urgently needed. In this context, the retrospective data of Chen et al ( 2 ), published online 14 May 2020, provided important insights that we would like to comment on in light of the results from our CORONADO (CORONAvirus SARS-CoV-2 and Diabetes Outcomes) study that was published online almost simultaneously on 29 May 2020 ( 3 ).…”

“…Considering the covariables before admission ( n = 748 participants, 74 deaths), older age ( P < 0.0001) and microvascular ( P = 0.0153) and macrovascular ( P = 0.0013) complications as well as treated obstructive sleep apnea ( P = 0.0013) were independently associated with early death. Regarding the covariates on admission ( n = 612 participants, 59 deaths), dyspnea ( P = 0.0049), increased CRP ( P = 0.0052) and AST ( P = 0.0003), and decreased estimated glomerular filtration rate ( P < 0.0001) and platelet count ( P = 0.0292) were independently associated with death on D7 ( 3 ). The discordant findings regarding the independent prognosis factors of COVID-19 severity between the two studies are probably due to a power issue in the study by Chen et al…”

Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19

“…In contrast, obesity was independently associated with COVID-19 severity. Additionally, systemic inflammation (measured by CRP) was also independently associated with early death (31). Thus, the influence of meta-inflammation in individuals with diabetes could play an important role in COVID-19 severe outcomes.…”

OSA as a probable risk factor for severe COVID-19

“…The Coronavirus Sars-Cov2 & Diabetes Outcomes study (CORONADO) is one of the first studies that provides evidence associating OSA to the severity of COVID-19. 4 CORONADO is a multicenter observational study in France that analyzed data from 1317 patients with diabetes hospitalized for COVID-19. Patients classified as treated OSA before admission had a higher odds ratio of death by day 7 (adjusted odds ratio, 2.65), suggesting that a diagnosis of OSA is an independent risk factor for poor COVID-19 outcome.…”