Correction to: Protective Effects of 28-O-Cafeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis

Liu, Xia; Ruan, Zhi; Shao, Xing-Cheng; Feng, Huijin; Wu, Lei; Wang, Wei; Wang, Hongmin; Mu, Huaiping; Zhang, Rujun; Zhao, Weimin; Zhang, Haiyan; Zhang, Nai-Xia

doi:10.1007/s11064-021-03243-y

Cited by 2 publications

(3 citation statements)

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“…During large depth (>100 msw) saturation diving, the central nervous system is continuously exposed to oxidative stress due to the excessive production of reactive oxygen species (ROS) triggered by the heliox-saturation pressurized environment [23,24]. An imbalance between oxidant and antioxidant levels is a common metabolic regulatory element in various neurological disorders, including Alzheimer's disease [25], autism spectrum disorder [26], ischemic brain [21], traumatic brain injury [27], and so on [18,28,29]. The level changes of SOD, MDA, and Gpx, as recognized indicators for oxidative stress, reflect the oxygen free radical…”

Section: Oxidative Stress Analysismentioning

confidence: 99%

Oxidative stress, dysfunctional energy metabolism, and destabilizing neurotransmitters altered the cerebral metabolic profile in a rat model of simulated heliox saturation diving to 4.0 MPa

Liu

Fang²,

Xu³

et al. 2023

PLoS ONE

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The main objective of the present study was to determine metabolic profile changes in the brains of rats after simulated heliox saturated diving (HSD) to 400 meters of sea water compared to the blank controls. Alterations in the polar metabolome in the rat brain due to HSD were investigated in cortex, hippocampus, and striatum tissue samples by applying an NMR-based metabolomic approach coupled with biochemical detection in the cortex. The reduction in glutathione and taurine levels may hypothetically boost antioxidant defenses during saturation diving, which was also proven by the increased malondialdehyde level, the decreased superoxide dismutase, and the decreased glutathione peroxidase in the cortex. The concomitant decrease in aerobic metabolic pathways and anaerobic metabolic pathways comprised downregulated energy metabolism, which was also proven by the biochemical quantification of the metabolic enzymes Na-K ATPase and LDH in cerebral cortex tissue. The significant metabolic abnormalities of amino acid neurotransmitters, such as GABA, glycine, and aspartate, decreased aromatic amino acids, including tyrosine and phenylalanine, both of which are involved in the metabolism of dopamine and noradrenaline, which are downregulated in the cortex. Particularly, a decline in the level of N-acetyl aspartate is associated with neuronal damage. In summary, hyperbaric decompression of a 400 msw HSD affected the brain metabolome in a rat model, potentially including a broad range of disturbing amino acid homeostasis, metabolites related to oxidative stress and energy metabolism, and destabilizing neurotransmitter components. These disturbances may contribute to the neurochemical and neurological phenotypes of HSD.

show abstract

Section: Oxidative Stress Analysismentioning

confidence: 99%

Oxidative stress, dysfunctional energy metabolism, and destabilizing neurotransmitters altered the cerebral metabolic profile in a rat model of simulated heliox saturation diving to 4.0 MPa

Liu

Fang²,

Xu³

et al. 2023

PLoS ONE

Self Cite

View full text Add to dashboard Cite

show abstract

“…During large depth (> 100 msw) saturation diving, the central nervous system is continuously exposed to oxidative stress due to the excessive production of reactive oxygen species (ROS) triggered by the helioxsaturation pressurized environment [24,25]. An imbalance between oxidant and antioxidant levels is a common metabolic regulatory element in various neurological disorders, including Alzheimer's disease [26], autism spectrum disorder [27], ischemic brain [22], traumatic brain injury[28], and so on [19,29,30]. The level changes of SOD, MDA, and Gpx, as recognized indicators for oxidative stress, re ect the oxygen free radical injury in vivo.…”

Section: Oxidative Analysismentioning

confidence: 99%

“…LDH catalyzed the conversion of pyruvate into Lac [27][28][29], and the decreased activities of LDH in the cortex downregulated the expression of Lac, indicating a decrease in anaerobic pathways. However, the concentration of Lac favored energetic metabolism through the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and LDH [29,30], which can also be incorporated into the glutamate, glutamine, and GABA cycles in neurons. In this study, compared with CON rats, a signi cantly higher concentration of FMA in the HSDX group and a decreased concentration of Suc may indicate an energy metabolism decline, which was further con rmed by an increased AMP and a decreased ATP produced mainly by glycolysis and the TCA cycle.…”

Section: Energy Metabolic Pathway Analysismentioning

confidence: 99%

Oxidative stress, dysfunctional energy metabolism, and destabilizing neurotransmitters altered cerebral metabolic profile in a rat model of a simulated heliox saturation diving to 4.0 Mpa

Liu

Fang

et al. 2022

Preprint

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A better understanding of the neurological molecular mechanisms induced by an extreme environment of hyperbaric decompression could contribute to the improvement of diving procedures. The main objective of the present study was to determine metabolic profile changes in the brains of rats after simulated heliox saturated diving (HSD) to 400 meters of sea water (msw) (4.0 MPa) with heliox to 5 bar (pO2 = 50 kPa) compared to the blank controls. Alterations in the polar metabolome in the rat brain due to hyperbaric heliox saturation were investigated in cortex, hippocampus, and striatum tissue samples by applying an NMR-based metabolomic approach coupled with biochemical detection in the cortex. The reduction in glutathione and taurine levels may hypothetically boost antioxidant defenses during saturation diving, which was also proven by the increased malondialdehyde level, the decreased superoxide dismutase, and the decreased glutathione peroxidase in the cortex. The concomitant decrease in aerobic metabolic pathways and anaerobic metabolic pathways comprised downregulated energy metabolism, which was also proven by the biochemical quantification of the metabolic enzymes Na-K ATPase and LDH in cerebral cortex tissue. The significant metabolic abnormalities of amino acid neurotransmitters, such as GABA, glycine, and aspartate, decreased aromatic amino acids, including tyrosine and phenylalanine, both of which are involved in the metabolism of dopamine and noradrenaline, which are downregulated in the cortex. In particular, a decline in the level of N-acetyl aspartate is associated with neuronal damage. In summary, hyperbaric decompression of a 400 msw HSD affected the brain metabolome in a rat model, potentially including a broad range of disturbing amino acid homeostasis, metabolites related to oxidative stress and energy metabolism, and destabilizing neurotransmitter components. These disturbances may contribute to the neurochemical and neurological phenotypes of HSD.

show abstract

Correction to: Protective Effects of 28-O-Cafeoyl Betulin (B-CA) on the Cerebral Cortex of Ischemic Rats Revealed by a NMR-Based Metabolomics Analysis

Cited by 2 publications

References 0 publications

Oxidative stress, dysfunctional energy metabolism, and destabilizing neurotransmitters altered the cerebral metabolic profile in a rat model of simulated heliox saturation diving to 4.0 MPa

Oxidative stress, dysfunctional energy metabolism, and destabilizing neurotransmitters altered the cerebral metabolic profile in a rat model of simulated heliox saturation diving to 4.0 MPa

Oxidative stress, dysfunctional energy metabolism, and destabilizing neurotransmitters altered cerebral metabolic profile in a rat model of a simulated heliox saturation diving to 4.0 Mpa

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