Correction to: Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury

Manek, Rachna; Moghieb, Ahmed; Yang, Zhihui; Kumar, Dhwani; Kobeissy, Firas; Sarkis, George Anis; Raghavan, Venkatesh; Wang, Kevin

doi:10.1007/s12035-018-0909-z

Cited by 55 publications

(4 citation statements)

References 43 publications

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“…Upregulation of molecular chaperones rescues the NF phenotype in SACS knockout neurons (Engert et al, 2000) and in motor neurons expressing mutant NfL associated with CMT (Tradewell et al, 2009). Chaperones have the potential to increase a more mobile pool of NF proteins accessible to secretory mechanisms such MVB (Manek et al, 2018).…”

Section: Release and Clearance Of Nf Peptides And Proteinsmentioning

confidence: 99%

Neurofilaments: neurobiological foundations for biomarker applications

Gafson

Barthélemy

Bomont

et al. 2020

Brain

220

208

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Interest in neurofilaments has risen sharply in recent years with recognition of their potential as biomarkers of brain injury or neurodegeneration in CSF and blood. This is in the context of a growing appreciation for the complexity of the neurobiology of neurofilaments, new recognition of specialized roles for neurofilaments in synapses and a developing understanding of mechanisms responsible for their turnover. Here we will review the neurobiology of neurofilament proteins, describing current understanding of their structure and function, including recently discovered evidence for their roles in synapses. We will explore emerging understanding of the mechanisms of neurofilament degradation and clearance and review new methods for future elucidation of the kinetics of their turnover in humans. Primary roles of neurofilaments in the pathogenesis of human diseases will be described. With this background, we then will review critically evidence supporting use of neurofilament concentration measures as biomarkers of neuronal injury or degeneration. Finally, we will reflect on major challenges for studies of the neurobiology of intermediate filaments with specific attention to identifying what needs to be learned for more precise use and confident interpretation of neurofilament measures as biomarkers of neurodegeneration.

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Section: Release and Clearance Of Nf Peptides And Proteinsmentioning

confidence: 99%

Neurofilaments: neurobiological foundations for biomarker applications

Gafson

Barthélemy

Bomont

et al. 2020

Brain

220

208

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“…These molecules move to their destination in EVs, which are small vesicles coated with a phospholipid bilayer and a cargo of bioactive molecules that represents the contents of the cell in which the vesicle originated [194][195][196]. EVs are released into the extracellular space by all cell types and, consequently, are ubiquitously present in biological fluids, for example, blood [197], urine [198], saliva [199], cerebrospinal fluid [200], and breast milk [201]. EV biogenesis represents an important evolutionary advancement because the cargo is protected from degradation by ribonucleases, deoxyribonucleases, and proteases present in the extracellular space.…”

Section: Extracellular Vesiclesmentioning

confidence: 99%

Molecular Pathways Implicated in Radioresistance of Glioblastoma Multiforme: What Is the Role of Extracellular Vesicles?

Burko

D’Amico

Miltykh

et al. 2023

IJMS

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Glioblastoma multiforme (GBM) is a primary brain tumor that is very aggressive, resistant to treatment, and characterized by a high degree of anaplasia and proliferation. Routine treatment includes ablative surgery, chemotherapy, and radiotherapy. However, GMB rapidly relapses and develops radioresistance. Here, we briefly review the mechanisms underpinning radioresistance and discuss research to stop it and install anti-tumor defenses. Factors that participate in radioresistance are varied and include stem cells, tumor heterogeneity, tumor microenvironment, hypoxia, metabolic reprogramming, the chaperone system, non-coding RNAs, DNA repair, and extracellular vesicles (EVs). We direct our attention toward EVs because they are emerging as promising candidates as diagnostic and prognostication tools and as the basis for developing nanodevices for delivering anti-cancer agents directly into the tumor mass. EVs are relatively easy to obtain and manipulate to endow them with the desired anti-cancer properties and to administer them using minimally invasive procedures. Thus, isolating EVs from a GBM patient, supplying them with the necessary anti-cancer agent and the capability of recognizing a specified tissue-cell target, and reinjecting them into the original donor appears, at this time, as a reachable objective of personalized medicine.

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“…In recent years, the changes in the exosomal content during the development of disease in patients with TBI have been extensively studied. Brain-injury biomarkers were detected in the CSF exosomes of patients with TBI, such as αII-spectrin breakdown products (BDPs), glial fibrillary acidic protein and its BDPs, ubiquitin C-terminal hydrolase-L1, synaptophysin, and Alix (Manek et al, 2018 ). This study found that after the occurrence of TBI, changes in the levels of exosomes and their markers in the plasma or CSF does not just diagnose TBI but also stages patients with TBI (Beard et al, 2020 ; Peltz et al, 2020 ).…”

Section: Exosomes and Traumatic Brain Injurymentioning

confidence: 99%

Role of Exosomes in Brain Diseases

Zhang

Chen

et al. 2021

Front. Cell. Neurosci.

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Exosomes are a subset of extracellular vesicles that act as messengers to facilitate communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are delivered by the exosomes to target molecules (such as proteins, mRNAs, or DNA) of host cells, thereby playing a key role in the maintenance of normal brain function. However, exosomes are also involved in the occurrence, prognosis, and clinical treatment of brain diseases, such as Alzheimer's disease, Parkinson's disease, stroke, and traumatic brain injury. In this review, we have summarized novel findings that elucidate the role of exosomes in the occurrence, prognosis, and treatment of brain diseases.

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Correction to: Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury

Abstract: The original version of this article unfortunately contained a typographical error on Author's name BFiras Kobessiy^. This should be corrected as BFiras Kobeissy^.

Cited by 55 publications

References 43 publications

Neurofilaments: neurobiological foundations for biomarker applications

Neurofilaments: neurobiological foundations for biomarker applications

Molecular Pathways Implicated in Radioresistance of Glioblastoma Multiforme: What Is the Role of Extracellular Vesicles?

Role of Exosomes in Brain Diseases

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