Correction to: Roles of nitric oxide and ethyl pyruvate after peripheral nerve injury

Panthi, Sandesh; Gautam, Kripa; Jung, Junyang

doi:10.1186/s41232-019-0091-3

Cited by 6 publications

(4 citation statements)

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“…The clinical use of FGFs for wound healing has been approved in China [ 45 ]. Several recent detailed reviews [ 45 , 46 , 47 ] focused on the application of recombinant FGFs for tissue repair are available.…”

Section: Fgf As Stimulators Of Regeneration and Repairmentioning

confidence: 99%

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Cellular Mechanisms of FGF-Stimulated Tissue Repair

Prudovsky

2021

Cells

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Growth factors belonging to the FGF family play important roles in tissue and organ repair after trauma. In this review, I discuss the regulation by FGFs of the aspects of cellular behavior important for reparative processes. In particular, I focus on the FGF-dependent regulation of cell proliferation, cell stemness, de-differentiation, inflammation, angiogenesis, cell senescence, cell death, and the production of proteases. In addition, I review the available literature on the enhancement of FGF expression and secretion in damaged tissues resulting in the increased FGF supply required for tissue repair.

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Section: Fgf As Stimulators Of Regeneration and Repairmentioning

confidence: 99%

“…The most versatile of FGFs is FGF1, which binds all known types of FGFRs [ 105 ]. The application of recombinant FGFs to repair various damaged tissues leads to a strongly enhanced cell proliferation [ 45 , 46 , 47 ].…”

Section: Cell Processes Underlying the Stimulation Of Tissue Repair Bmentioning

confidence: 99%

Cellular Mechanisms of FGF-Stimulated Tissue Repair

Prudovsky

2021

Cells

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“…A relatively small number of HLA homozygous lines could be sufficient to provide immune matched cells to a large percentage of the world’s population. It is estimated that by selecting those homozygous for the 10 most frequent HLA-A,- B, or - DRB1 haplotypes, 10, 75, and 140 HLA-homozygous iPSC lines would match approximately 50%, 80%, and 90% of the Korean/Japanese population, respectively [ 170 , 171 ]. This strategy would be more challenging for populations with higher racial and genetic diversity such as the US.…”

Section: Current Challengesmentioning

confidence: 99%

Human Pluripotent Stem Cells-Based Therapies for Neurodegenerative Diseases: Current Status and Challenges

Ford

Pearlman

Ruan

et al. 2020

Cells

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Neurodegenerative diseases are characterized by irreversible cell damage, loss of neuronal cells and limited regeneration potential of the adult nervous system. Pluripotent stem cells are capable of differentiating into the multitude of cell types that compose the central and peripheral nervous systems and so have become the major focus of cell replacement therapies for the treatment of neurological disorders. Human embryonic stem cell (hESC) and human induced pluripotent stem cell (hiPSC)-derived cells have both been extensively studied as cell therapies in a wide range of neurodegenerative disease models in rodents and non-human primates, including Parkinson’s disease, stroke, epilepsy, spinal cord injury, Alzheimer’s disease, multiple sclerosis and pain. In this review, we discuss the latest progress made with stem cell therapies targeting these pathologies. We also evaluate the challenges in clinical application of human pluripotent stem cell (hPSC)-based therapies including risk of oncogenesis and tumor formation, immune rejection and difficulty in regeneration of the heterogeneous cell types composing the central nervous system.

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“…The interleukin (IL)-1 family plays multifaceted roles in tumoral immunity [ 43 , 44 ]. It includes seven ligands with pro-inflammatory activity (IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL-36γ), as well as anti-inflammatory cytokines (IL-37 and IL-38) [ 43 , 45 ], having crucial roles in host-defense responses, but also in inflammatory responses that contribute to cancer development [ 46 ].…”

Section: Introductionmentioning

confidence: 99%

NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer

et al. 2021

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Breast cancer is the most diagnosed malignancy in women. Increasing evidence has highlighted the importance of chronic inflammation at the local and/or systemic level in breast cancer pathobiology, influencing its progression, metastatic potential and therapeutic outcome by altering the tumor immune microenvironment. These processes are mediated by a variety of cytokines, chemokines and growth factors that exert their biological functions either locally or distantly. Inflammasomes are protein signaling complexes that form in response to damage- and pathogen-associated molecular patterns (DAMPS and PAMPS), triggering the release of pro-inflammatory cytokines. The dysregulation of inflammasome activation can lead to the development of inflammatory diseases, neurodegeneration, and cancer. A crucial signaling pathway leading to acute and chronic inflammation occurs through the activation of NLRP3 inflammasome followed by caspase 1-dependent release of IL-1β and IL-18 pro-inflammatory cytokines, as well as, by gasdermin D-mediated pyroptotic cell death. In this review we focus on the role of NLRP3 inflammasome and its components in breast cancer signaling, highlighting that a more detailed understanding of the clinical relevance of these pathways could significantly contribute to the development of novel therapeutic strategies for breast cancer.

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Correction to: Roles of nitric oxide and ethyl pyruvate after peripheral nerve injury

Cited by 6 publications

References 1 publication

Cellular Mechanisms of FGF-Stimulated Tissue Repair

Cellular Mechanisms of FGF-Stimulated Tissue Repair

Human Pluripotent Stem Cells-Based Therapies for Neurodegenerative Diseases: Current Status and Challenges

NLRP3 inflammasome-mediated cytokine production and pyroptosis cell death in breast cancer

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