Correction to: Seroprevalence and determinants of transfusion transmissible infections among voluntary blood donors in Homabay, Kisumu and Siaya counties in western Kenya

Onyango, Calleb George; Ogonda, Lilian; Guyah, Bernard; Okoth, Peter; Shiluli, Clement; Humwa, Felix; Opollo, Vallarie

doi:10.1186/s13104-018-3521-4

Cited by 5 publications

(3 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This prevalence is lower compared to a 5.6% seroprevalence reported among the same group of people in Nakuru and Tenwek Mission hospital, Kenya, using ELISA testing [ 22 ] and similar to 2.4% reported among blood donors in Nyeri in 2016 on samples collected in 2014 using Murex HBsAg version 3 which is a rapid and sensitive enzyme immunoassay [ 23 ]. On other hand, this prevalence is however higher than the 0.4% reported in Eldoret in 2018 [ 24 ] and lower than the 3.46% described in Kisumu, Homabay and Siaya counties in 2018 [ 25 ]. These differences in seroprevalence could be attributed to variations in geographical locations and the sensitivity of the screening techniques used in the detection of the HBsAg for the different studies.…”

Section: Discussionmentioning

confidence: 73%

Seroprevalence and genotypic characterization of HBV among low risk voluntary blood donors in Nairobi, Kenya

Aluora

Muturi

Gachara

2020

Virol J

View full text Add to dashboard Cite

Background Hepatitis B virus (HBV) causes significant morbidity and mortality globally primarily due to its ability to cause hepatitis, liver cirrhosis and hepatocellular carcinoma. The Kenya National Blood Transfusion Services screens for Hepatitis B antibodies using the chemiluminescent microparticle immunoassay method. This test does not inform on the genotypic characteristics of the virus or the actual presence of the virus in blood. This study therefore sought to determine the serologic and genotypic profiles of HBV circulating among the voluntary blood donors in Nairobi. Methods Blood samples were collected in plain and EDTA vacutainers and tested for the Hepatitis B surface antigen (HBsAg). HBV DNA was then extracted from plasma, its overlapping P/S gene amplified and sequenced. The resulting sequences were used to analyze for the circulating genotypes and mutations within the P and S genes. Bivariate statistical analysis was used to determine the association between demographic factors and HBV infection. Results A seroprevalence of 2.3% (n = 7) was reported. The age group 19–28 years was significantly associated with HBV infection. Nine samples were positive for HBV DNA; these included 2 HBsAg positive samples and 7 HBsAg negative samples. Genotype A, sub genotype A1 was found to be exclusively prevalent while a number of mutations were reported in the “a” determinant segment of the major hydrophilic region of the S gene associated with antibody escape. RT mutations including mutation rt181T in the P gene conferring resistance against Lamivudine and other ʟ-nucleoside drugs were detected. Conclusion There is a high prevalence of occult HBV infections among these blood donors and therefore the testing platform currently in use requires revision.

show abstract

Section: Discussionmentioning

confidence: 73%

Seroprevalence and genotypic characterization of HBV among low risk voluntary blood donors in Nairobi, Kenya

Aluora

Muturi

Gachara

2020

Virol J

View full text Add to dashboard Cite

show abstract

“…The HBV seroprevalence in voluntary blood donors was marginally higher compared to the 2.3% seroprevalence recorded in the same group in a study carried out in Nairobi, Kenya using the chemiluminescent microparticle immunoassay (CMIA) [8] and similar to (3.46%) seroprevalence from a study carried out in Kisumu, Homabay and Siaya Counties, Kenya using ELISA and confirmed by CMIA [7].…”

Section: Discussionmentioning

confidence: 48%

“…Kenya has been categorized with other sub-Saharan African countries with a HBV infection burden of chronic states of intermediate range (2% -7%) and high (≥8%) [4]. Studies have shown HBV infection disparity in Kenya among various study populations, with 5.1% prevalence in areas near Nairobi among rural settler community, 15.3% in Turkana County among pregnant women [6], 3.46% in Kisumu, Homabay and Siaya Counties [7] and 2.3% in Nairobi [8] among blood donors. Diagnosis of HBV is routinely done by measurement of various HBV specific antigens and antibodies.…”

Section: Introductionmentioning

confidence: 99%

Comparative Seroprevalence of Hepatitis B Virus among in-Mates and Low Risk Voluntary Blood Donors in Garissa, Kenya

Bahati¹,

Bulimo²,

Gachara³

2021

JBM

View full text Add to dashboard Cite

Hepatitis B virus (HBV) infection is a potentially life-threatening infection that attacks the liver and can cause both acute and chronic disease. This creates a high risk of death from cirrhosis and liver cancer. Hepatitis B infection poses a major health concern globally. It is estimated that 257 million people are infected globally with 780,000 deaths reported annually. In Kenya, HBV prevalence stands at chronic states of intermediate range (5% -7%) and high (≥8%) with regional variations. Garissa County carries a high HBV infection risk with a reported prevalence of 14.1% in pregnant women attending antenatal care (ANC) clinics. This study was carried out to determine and compare the seroprevalence of HBV among in-mates and voluntary blood donors at Garissa Main Prison and Garissa County referral hospital respectively in Garissa, Kenya. A total of 130 in-mates and 130 voluntary blood donors were sampled in this study. Serum was tested for Hepatitis B surface antigen (HBsAg) using a rapid test cassette (Amitech Diagnostics Inc.). A questionnaire was also used to collect socio-demographic factors of the study participants. Data were entered and analyzed using SPSS version 20. Majority of the study participants were males (86.9% among inmates and 95.4% among blood donors). Majority (76.2%) of the in-mates and of the donors (83.1%) were aged between 20 -40 years while majority (51.4% of the donors and 81.5% of in mates) had only a primary school level of education. HBV seroprevalence was significantly higher among in mates compared to blood donors. Out of the total number of in-mates tested, 7 (5.4%) were HBV seropositive. Conversely, among blood donors 4 (3.1%) were seropositive. There was a significant association between HBV seropositivity and gender among both the blood donors and in-mates. There was no significant association between HBV seropositivity and both level of education and age. No data currently

show abstract

Blood Transfusion-Associated Infections in the Twenty-First Century: New Challenges

Fong

2020

Current Trends and Concerns in Infectious Diseases

View full text Add to dashboard Cite

Correction to: Seroprevalence and determinants of transfusion transmissible infections among voluntary blood donors in Homabay, Kisumu and Siaya counties in western Kenya

Cited by 5 publications

References 1 publication

Seroprevalence and genotypic characterization of HBV among low risk voluntary blood donors in Nairobi, Kenya

Seroprevalence and genotypic characterization of HBV among low risk voluntary blood donors in Nairobi, Kenya

Comparative Seroprevalence of Hepatitis B Virus among in-Mates and Low Risk Voluntary Blood Donors in Garissa, Kenya

Blood Transfusion-Associated Infections in the Twenty-First Century: New Challenges

Contact Info

Product

Resources

About