Correction to: Techniques to Avoid Complications of Atrial Fibrillation Ablation

Apte, Nachiket; Shrestha, Amit; Dendi, Raghuveer

doi:10.1007/s11936-020-00864-4

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“…1 Despite continuing advances in ablation technologies for lesion efficacy, the use of these energy sources is still associated with rare but potentially serious complications resulting from injury to targeted and adjacent tissues, such as pulmonary vein (PV) stenosis, phrenic nerve palsy, and atrio-esophageal fistula. 1,2 Various procedural techniques are currently employed with the aim of minimizing the risk of these complications, 1,3 but the challenge of balancing ablation effectiveness and safety remains.…”

Section: Introductionmentioning

confidence: 99%

In vivo porcine characterization of atrial lesion safety and efficacy utilizing a circular pulsed‐field ablation catheter including assessment of collateral damage to adjacent tissue in supratherapeutic ablation applications

Hsu

Gibson

Banker³

et al. 2022

Cardiovasc electrophysiol

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Introduction: Pulsed-field ablation (PFA), an ablative method that causes cell death by irreversible electroporation, has potential safety advantages over radiofrequency ablation and cryoablation. Pulmonary vein (PV) isolation was performed in a porcine model to characterize safety and performance of a novel, fully-integrated biphasic PFA system comprising a multi-channel generator, variable loop circular catheter, and integrated PFA mapping software module.Methods: Eight healthy porcine subjects were included. To evaluate safety, multiple ablations were performed, including sites not generally targeted for therapeutic ablation, such as the right inferior PV lumen, right superior PV ostium, and adjacent to the esophagus and phrenic nerve. To evaluate the efficacy, animals were recovered, followed for 30(±3) days, then re-mapped. Gross pathological and histopathological examinations assessed procedural injuries, chronic thrombosis, tissue ablation, penetration depth, healing, and inflammatory response.Results: All eight animals survived follow-up. PV narrowing was not observed acutely nor at follow-up, even when ablation was performed deep to the PV ostium.

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