Correction to: The prevalence and associated factors of alcohol use among pregnant women attending antenatal care at public hospitals Addis Ababa, Ethiopia, 2019

Tesfaye, Getaneh; Demlew, Demeke; G/tsadik, Meseret; Habte, Fikreselam; Molla, Gebeyaw; Kifle, Yohannes; Gebreegziabhier, Gebreslassie

doi:10.1186/s12888-020-02876-7

Cited by 3 publications

(12 citation statements)

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“…The main characteristics of all included studies presented in S3A and S3B Table . Overall, 7 studies assessed khat use only [6,7,10,[38][39][40][41], and 12 studies assessed alcohol consumption only [21,[24][25][26][27][28][29][30][31][32][33][34], and 4 studies assessed both khat and alcohol use during pregnancy [19,20,22,38]. These studies were all cross-sectional and conducted in 5 regions of Ethiopia between 2014 and 2020.…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Several alcohol use epidemiological studies among pregnant women are available in Ethiopia. However, the results of these studies showed a wide variation of prevalence ranging from 4.10 to 76.70% [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] over time and across geographical areas. Similarly, a national study conducted using Ethiopian Demographic Health Survey (EDHS) 2016 data showed that the spatial distribution of alcohol consumption was highly variable across the country.…”

Section: Introductionmentioning

confidence: 99%

“…Studies on pregnant women in Ethiopia showed that the prevalence of khat use in pregnant women ranges between 5.8% and 65.8% [6,7,10,19,20,22,23,[38][39][40][41]. Regional distribution of khat use in Ethiopia can be described as ranging from 15.5% to 37.2% in Harar region [10,38,40], 9.9% to 35.8% in Southern Ethiopia [23,39], 5.8% to 65.8% in Oromia region [19,20,29,41] and 15.3% in Addis Ababa city [6].…”

Section: Introductionmentioning

confidence: 99%

“…Several factors have been found to increase the likelihood of alcohol use during pregnancy. Alcohol use during pregnancy has been found to be significantly associated with: urban residence [21], low educational level [27,29,30,32,34], history of pre-pregnancy alcohol use [21,27,29], khat chewing [21], history of abortion [21,24,30], unplanned pregnancy [21,27,29,30], poor social support [24,27,29,30], mental distress [21,24,27,29], and a lack of knowledge about the harmful fetal effects of alcohol use [27,30]. Besides this, partner alcohol use is one of the factors that contributes to the likelihood of alcohol use [29].…”

Section: Introductionmentioning

confidence: 99%

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The epidemiology of khat (catha edulis) chewing and alcohol consumption among pregnant women in Ethiopia: A systematic review and meta-analysis

Wogayehu,

Demissie,

Wolka

et al. 2023

PLOS Glob Public Health

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The use of khat (Catha edulis) and alcohol during pregnancy is a serious public health problem that has been associated with a number of harmful outcomes for both the fetus and the mother’s health. There has been no systematic review with meta-analysis to determine risk factors associated with khat and alcohol use among pregnant women in Ethiopia. Therefore, we aimed to determine the pooled prevalence and risk factors of khat and alcohol use during pregnancy in Ethiopia. This review has been registered in PROSPERO with protocol ID: CRD42023395115. Studies identified from PubMed, Google Scholar, the WHO African Index Medicus, the Cochrane Library, African Journal Online, and Science Direct. Articles published from January 1, 2000 to February 10, 2023 were included. We searched for articles that included any combination of the following key terms: “khat”, “qat”, “alcohol”, “ethanol”, “prevalence”, “factors”, “pregnant” and “Ethiopia”. Two reviewers worked independently to screen studies and extract data. A funnel plot and Egger’s regression test were used to test publication bias. A forest plot was used to present the pooled prevalence and odds ratio with a 95% confidence interval (CI) using the random effect model. I2 metrics were used to assess heterogeneity. The meta-analysis was carried out with Stata 14.0 software. Nine hundred sixty-two records were retrieved from different sources, and 23 studies were included in the final analysis. The pooled prevalence of khat use and alcohol drinking during pregnancy was 26.6% (95% CI 17.8, 35.5) and 31.65% (95% CI: 21.8, 41.5), respectively. Partner khat use (OR 5.9 [95% CI (2.4, 14.5)]) was associated factor for khat use during pregnancy. Low educational level (OR 2.54 [95% CI (1.8, 3.5)]), pre-pregnancy alcohol use (OR 3.5 [95% CI (2.6, 4.7)]), unplanned pregnancy (OR 2.7 [95% CI (1.8, 4.0)]), history of abortion (OR 2.3 [95% CI (1.4, 3.7)]), poor social support (OR 3.3 [95% CI (2.0, 5.3)]), and mental distress (OR 2.6 [95% CI (2.0, 3.3)]) were associated factors for alcohol drinking during pregnancy. This review indicated that the magnitude of khat and alcohol use during pregnancy in Ethiopia was high. Targeted interventions for groups of pregnant women at high risk of khat and alcohol use are urgently needed. Community-based health education interventions and point-of-sale warnings are essential to reduce the burden. Future studies should consider the influence of community-level factors on khat and alcohol use during pregnancy.

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Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The epidemiology of khat (catha edulis) chewing and alcohol consumption among pregnant women in Ethiopia: A systematic review and meta-analysis

Wogayehu,

Demissie,

Wolka

et al. 2023

PLOS Glob Public Health

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“…Alcohol is a psychoactive substance with several neurobiological effects that can cause both acute and chronic injury in the brain, including neuroin ammation and neurodegeneration [7]. Further, microglia, a resident macrophage of the CNS, can be activated in the brain after excessive alcohol intake [8].…”

Section: Introductionmentioning

confidence: 99%

Sodium butyrate alleviates chronic alcoholic neuroinflammation by regulating microgila polarization through GPR109A / PPAR-γ / NF-κB signaling pathway

Wei

Ren

et al. 2022

Preprint

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Background Alcohol can cause neuroinflammation, leading to neuron damage and further memory and cognitive impairment. Recent animal studies have shown that the exposure to chronic alcohol consumption induces robust inflammatory microglial activation in the brain. However, as a novel anti-inflammation approach, the impact of sodium butyrate on chronic alcohol-induced neuroinflammation still remains unclear. Methods Sixty female C57BL/6J mice were randomly divided into 4 groups: pair-fed (PF) group (PF/CON), alcohol-fed (AF) group (AF/CON), PF with sodium butyrate (NaB) group (PF/NaB) and AF with NaB group (AF/NaB). Each group was fed a modified Lieber-DeCarli liquid diet with or without alcohol. Mice were subjected to different behavioral tests to assess aberrant behaviours (deficits in cognitive functions, depression and anxiety). Pathological changes were further investigated by Hematoxylin and eosin staining (HE) and Nissl staining. The microglial activation and microglial polarization were observed by immunohistochemistry (IHC), immunofluorescence (IF) and flow cytometry. Enzyme-linked immunosorbent assay (ELISA) was used to determine the levels of inflammatory factors. G-protein coupled receptor 109A (GPR109A), peroxisome proliferator-activated receptor γ (PPAR-γ) and nuclear factor-κB (NF-κB) mRNA and protein levels were evaluated by reverse transcription‑quantitative (RT‑q) PCR and western blot (WB). Results As indicated by the behavioural tests, inflammatory indicators, microglial activation (M1/M2 microglia polarization) and brain morphology, sodium butyrate administration ameliorated aberrant behaviours (locomotor hypoactivity, anxiety disorders and depressive behaviours, impaired learning and spatial recognition memory), effectively reduced neuroinflammation and neuronal damage. The effectiveness of sodium butyrate may attribute to the GPR109A receptor in microglia by up-regulating the expression of PPAR-γ and inhibiting the activation of NF-κB. Conclusion Sodium butyrate ameliorates neuroinflammation induced by chronic alcohol exposure and improves memory and cognitive functions in mice via modulating microglia-mediated GPR109A / PPAR-γ / NF-κB signaling pathway.

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Magnitude and risk factors of khat, alcohol and cigarettes use among pregnant women in Africa: a systematic review and meta-analysis

Wogayehu,

Demissie,

Alemayehu

et al. 2024

BMC Pregnancy Childbirth

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Background The use of khat, alcohol, and cigarettes during pregnancy is a serious public health problem associated with harmful outcomes for the fetus and the mother’s health. Studies that investigated khat, alcohol, and cigarettes usage during pregnancy yielded varied and contradictory results. This study used a systematic review and meta-analysis to estimate the pooled prevalence and associated factors of khat, alcohol, and cigarettes use among pregnant women in Africa. Methods A review of eligible studies was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. This review has been registered in PROSPERO with protocol ID CRD42021289074. Literature published in English from January 1, 2002 to November 30, 2021 was retrieved from PubMed, Google Scholar, Cochrane, HINARI, African Journal Online, and Science Direct databases. The quality of included articles was assessed using the Joanna Briggs Institute’s (JBI) critical appraisal checklist. The I 2 statistic and Cochran’s Q test were used to assess the presence of heterogeneity between studies. To assess publication bias, a funnel plot and Egger’s regression test were utilized. The random effect model was used to estimate the summary prevalence and the corresponding 95% confidence interval (CI) of risk factors for khat, alcohol, and cigarettes use. Results Out of the 1509 studies identified, 71 met the inclusion criteria. The pooled prevalence of khat chewing, alcohol drinking, active smoking, and secondhand smoke exposure during pregnancy was 18.93%, 22.20%, 11.85%, and 43.45%, respectively. The subgroup analysis by UN sub-region showed the highest pooled prevalence of alcohol use during pregnancy in Middle Africa (25.69%) and the lowest in Northern Africa (1.10%). Several factors were identified as risk factors for alcohol use, including low educational level, younger age women, pre-pregnancy alcohol use, unplanned pregnancy, history of abortion, poor social support, mental distress, poor knowledge on alcohol risks, and partner alcohol use. Conclusion This review indicated that the pooled magnitude of khat, alcohol and cigarette use during pregnancy was higher in Africa. Substance use screening and brief interventions (SBI) should be routinely delivered in antenatal care settings to reduce pregnant women’s substance use. Supplementary Information The online version contains supplementary material available at 10.1186/s12884-024-06999-7.

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Correction to: The prevalence and associated factors of alcohol use among pregnant women attending antenatal care at public hospitals Addis Ababa, Ethiopia, 2019

Abstract: An amendment to this paper has been published and can be accessed via the original article.

Cited by 3 publications

References 1 publication

The epidemiology of khat (catha edulis) chewing and alcohol consumption among pregnant women in Ethiopia: A systematic review and meta-analysis

The epidemiology of khat (catha edulis) chewing and alcohol consumption among pregnant women in Ethiopia: A systematic review and meta-analysis

Sodium butyrate alleviates chronic alcoholic neuroinflammation by regulating microgila polarization through GPR109A / PPAR-γ / NF-κB signaling pathway

Magnitude and risk factors of khat, alcohol and cigarettes use among pregnant women in Africa: a systematic review and meta-analysis

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