Correction to: The role of oral co-trimoxazole in treating Nocardia farcinica keratitis: a case report

Sharma, Neharika; O’Hagan, Stephen

doi:10.1186/s12348-017-0143-2

Cited by 6 publications

(3 citation statements)

References 2 publications

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“…The use of topical applications, subconjunctival, parabulbar or intraocular injections of SOD1 could, therefore, provide a supplement for intrinsic antioxidants in eye tissues, which may be depleted at oxidative stress. According to statistics, inflammatory eye diseases, accompanied by oxidative stress, are the most common eye pathologies that lead to partial disability and, sometimes, to the complete loss of vision [ 21 , 22 , 23 ]. It was shown that both subconjunctival injections and topical applications of SOD1 solutions were effective in preventing corneal perforations under acute inflammation of the eye after alkali burns [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Superoxide Dismutase 1 Nanoparticles (Nano-SOD1) as a Potential Drug for the Treatment of Inflammatory Eye Diseases

et al. 2021

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Inflammatory eye diseases remain the most common clinical problem in ophthalmology. The secondary processes associated with inflammation, such as overproduction of reactive oxygen species (ROS) and exhaustion of the endogenous antioxidant system, frequently lead to tissue degeneration, vision blurring, and even blindness. Antioxidant enzymes, such as copper–zinc superoxide dismutase (SOD1), could serve as potent scavengers of ROS. However, their delivery into the eye compartments represents a major challenge due to the limited ocular penetration. This work presents a new therapeutic modality specifically formulated for the eye on the basis of multilayer polyion complex nanoparticles of SOD1 (Nano-SOD1), which is characterized by appropriate storage stability and pronounced therapeutic effect without side reactions such as eye irritation; acute, chronic, and reproductive toxicity; allergenicity; immunogenicity; mutagenicity even at high doses. The ability of Nano-SOD1 to reduce inflammatory processes in the eye was examined in vivo in rabbits with a model immunogenic uveitis—the inflammation of the inner vascular tract of the eye. It was shown during preclinical studies that topical instillations of Nano-SOD1 were much more effective compared to the free enzyme in decreasing uveitis manifestations. In particular, we noted statistically significant differences in such inflammatory signs in the eye as corneal and conjunctival edema, iris hyperemia, and fibrin clots. Moreover, Nano-SOD1 penetrates into interior eye structures more effectively than SOD itself and retains enzyme activity in the eye for a much longer period of time, decreasing inflammation and restoring antioxidant activity in the eye. Thus, the presented Nano-SOD1 can be considered as a potentially useful therapeutic agent for the treatment of ocular inflammatory disorders.

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Section: Introductionmentioning

confidence: 99%

Superoxide Dismutase 1 Nanoparticles (Nano-SOD1) as a Potential Drug for the Treatment of Inflammatory Eye Diseases

et al. 2021

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“…In addition to PE, Nocardia species can cause human skin, lungs, and central nervous system infections, as well as systemic nocardiosis, especially in immunocompromised patients [5][6][7]. In terms of ocular pathology, Nocardia can cause keratitis, keratoconjunctivitis, scleritis, dacryocystitis, orbital cellulitis, and both exogenous and endogenous endophthalmitis have been described [9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Post-traumatic exogenous endophthalmitis caused by Nocardia farcinica

Burdová

Donátová

Mahelková

et al. 2021

J Ophthal Inflamm Infect

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A case report of post-traumatic exogenous endophthalmitis caused by Nocardia farcinica, including treatment procedures, microbiology examination, and systemic medications. A 23-year-old male suffered a penetrating corneal injury that was treated with sutures. On the thirteenth day after the final suture was removed, an anterior uveitis developed and progressed to whitish, plump, nodular, and tufted exudates within the anterior chamber over the next 10 days; this led to an indication for intraocular surgery. Anterior chamber lavage and resection of solid fibrinous exudates (using a vitrectomy knife) for a complete microbiological examination were performed. Nocardia farcinica was identified. Systemic medications were chosen according to sensitivity, and a fixed combination of sulfamethoxazole 400 mg/trimethoprim 80 mg was administered long-term (months). In this case, accurate, early detection of an atypical infectious agent and determination of its sensitivity to antibiotic treatment enabled effective treatment that achieved the best functional and anatomical results under the circumstances.

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“…In addition to PE, Nocardia species can cause human skin, lungs, and central nervous system infections, as well as systemic nocardiosis, especially in immunocompromised patients [7,8,9]. In terms of ocular pathology, Nocardia can cause keratitis, keratoconjunctivitis, scleritis, dacryocystitis, orbital cellulitis, and both exogenous and endogenous endophthalmitis have been described [11,12,13,14,15]. This paper reports on a case of PE caused by Nocardia farcinica after a penetrating corneal injury and its treatment.…”

Section: Introductionmentioning

confidence: 99%

Post-Traumatic Exogenous Endophthalmitis Caused By Nocardia Farcinica

Burdová

Donátová

Mahelková

et al. 2021

Preprint

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A case report of post-traumatic exogenous endophthalmitis caused by Nocardia farcinica, including treatment procedures, microbiology examination, and systemic medications. A 23-year-old male suffered a penetrating corneal injury that was treated with sutures. The sutures were individually removed during the 4th and 5th months after surgery. On the thirteenth day after the final suture was removed, an anterior uveitis developed and progressed to whitish, plump, nodular, and tufted exudates within the anterior chamber over the next 10 days; this led to an indication for intraocular surgery. Anterior chamber lavage and resection of solid fibrinous exudates (using a vitrectomy knife) for a complete microbiological examination were performed. Nocardia farcinica was identified. Systemic medications were chosen according to sensitivity, and a fixed combination of sulfamethoxazole 400 mg/trimethoprim 80 mg was administered long-term (months). After a complicated course, the final visual acuity was 0.5. In this case, accurate, early detection of an atypical infectious agent and determination of its sensitivity to antibiotic treatment enabled effective treatment that achieved the best functional and anatomical results under the circumstances.

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Correction to: The role of oral co-trimoxazole in treating Nocardia farcinica keratitis: a case report

Cited by 6 publications

References 2 publications

Superoxide Dismutase 1 Nanoparticles (Nano-SOD1) as a Potential Drug for the Treatment of Inflammatory Eye Diseases

Superoxide Dismutase 1 Nanoparticles (Nano-SOD1) as a Potential Drug for the Treatment of Inflammatory Eye Diseases

Post-traumatic exogenous endophthalmitis caused by Nocardia farcinica

Post-Traumatic Exogenous Endophthalmitis Caused By Nocardia Farcinica

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