Correlates of Adjuvant Therapy Attitudes in African American Breast Cancer Patients

Edmonds, Megan C.; Sutton, Arnethea L.; He, Jun; Perera, Robert A.; Sheppard, Vanessa B.

doi:10.1016/j.jnma.2020.02.006

Cited by 4 publications

(8 citation statements)

References 41 publications

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“…Black women were found to have greater perceived severity compared to White women. This finding builds upon our earlier study where we investigated correlates of adjuvant treatment attitudes in Black BC patients, to build a deeper understanding of Black BC patients treatment decisions 15 . In our study Black women with higher perceived severity levels was positively associated with positive chemotherapy attitudes 15 .…”

Section: Discussionsupporting

confidence: 75%

“…Breast cancer (BC) survivors health beliefs are important drivers of their health behaviors 59,60 including adjuvant treatment decisions and uptake of preventative health care services 15,23 . Unfortunately, BC beliefs are understudied in BC survivors.…”

Section: Discussionmentioning

confidence: 99%

“…A deeper analysis of BC survivors' beliefs about their cancer is critically important to better understand survivors screening behaviors and inform effective planning of navigation strategies during survivorship care, such as breast surveillance guidelines 24,25 . While, there is a widespread of BC‐related research on women's perceived severity and susceptibility from the general population, 26‐31 very few studies have observed susceptibility to a BC recurrence and disease severity among BC survivors 15,23,32,33 . More recently we investigated Black BC survivor's adjuvant treatment attitudes, and found women reporting higher susceptibility to a BC recurrence had more positive adjuvant endocrine therapy attitudes, and women with higher disease severity and susceptibility to a BC recurrence had more positive chemotherapy attitudes 15 .…”

Section: Introductionmentioning

confidence: 97%

“…While, there is a widespread of BC‐related research on women's perceived severity and susceptibility from the general population, 26‐31 very few studies have observed susceptibility to a BC recurrence and disease severity among BC survivors 15,23,32,33 . More recently we investigated Black BC survivor's adjuvant treatment attitudes, and found women reporting higher susceptibility to a BC recurrence had more positive adjuvant endocrine therapy attitudes, and women with higher disease severity and susceptibility to a BC recurrence had more positive chemotherapy attitudes 15 . Another study found a positive association with readiness for genetic counseling among high‐risk BC survivors with greater perceived severity of their cancer 23 .…”

Section: Introductionmentioning

confidence: 97%

“…Reasons for survival disparities are multifaceted involving the underuse of adjuvant treatment, screening, late‐stage diagnosis, as well as structural factors (e.g., medical mistrust), and inequality of social factors such as, health care access and neighborhood inequality 6‐11 . To better understand and improve disparities in breast cancer outcomes, such as mammography screening health beliefs are widely studied 12‐15 . In fact, extensive research in BC beliefs from the general population of women has aided in successful mammography screening interventions 16‐19 ; however, limited research has observed breast cancer‐related beliefs among BC survivors 20‐23 .…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Influential factors in Black and White breast cancer survivors' beliefs about breast cancer

Edmonds

Dahman

McGuire³

et al. 2021

Psycho-Oncology

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Purpose Breast cancer beliefs are widely studied to improve preventative screening behaviors in women without cancer; however, limited research has examined breast cancer beliefs among breast cancer survivors. To fill this gap in research we investigated racial differences and the predicting role of influential factors (e.g., stage) in survivors' beliefs about their breast cancer. Methods This study is a secondary analysis of data from the Narrowing Gap in Adjuvant Therapy Study (2006–2011), where Black (N = 210) and White women (N = 149) were interviewed within 20 weeks following their breast cancer diagnosis and primary surgery in Washington DC and Detroit, MI. Outcomes of this analysis were perceived susceptibility to a breast cancer recurrence and perceived severity of breast cancer. Bivariate analyses were conducted to assess racial differences in sample characteristics, and on the study outcomes. Adjusted multiple regression models examined correlates between independent variables (e.g., sociodemographic/clinical) and women's breast cancer beliefs about susceptibility of a recurrence and disease severity. Results Most of the sample were Black women (58%), had breast‐conserving surgery (64%), and were privately insured (67%). Black women reported higher perceived disease severity beliefs than White women (p = 0.004). Other associated factors with greater perceived severity beliefs included lower education (p = 0.008), public health insurance (p = 0.021) and greater levels of medical mistrust (p = 0.016). In our adjusted multiple regression models' women with lower satisfaction regarding financial aspects of their healthcare were more likely to have higher perceived severity beliefs (p = 0.007); women with stage II cancer compared to stage I had greater susceptibility beliefs to a cancer recurrence (p = 0.001). Conclusion We found racial differences in women's perceived severity beliefs, and identified theory‐based clinical and psychosocial correlates in survivor's breast cancer beliefs by race. Specifically, women diagnosed at stage (II) compared to stage (I) reported greater perceived susceptibility to a recurrence. Survivors diagnosed at stage (I) and (III) cancers may serve as important target groups to monitor their surveillance and follow‐up behaviors. This study contributes salient predictors in survivors' beliefs about their BC and informs navigation strategies to improve cancer survivorship recommendations in the context of psycho‐oncology and follow‐up cancer care.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Influential factors in Black and White breast cancer survivors' beliefs about breast cancer

Edmonds

Dahman

McGuire³

et al. 2021

Psycho-Oncology

Self Cite

View full text Add to dashboard Cite

show abstract

Assessing Perceived Discrimination as Reported by Black and White Women Diagnosed with Breast Cancer

Sutton

Hagiwara

Perera

et al. 2020

J. Racial and Ethnic Health Disparities

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Deregulated miRNA Expression in Triple-Negative Breast Cancer of Ancestral Genomic-Characterized Latina Patients

Almohaywi,

Sugita,

Centa

et al. 2023

IJMS

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Among patients with triple-negative breast cancer (TNBC), several studies have suggested that deregulated microRNA (miRNA) expression may be associated with a more aggressive phenotype. Although tumor molecular signatures may be race- and/or ethnicity-specific, there is limited information on the molecular profiles in women with TNBC of Hispanic and Latin American ancestry. We simultaneously profiled TNBC biopsies for the genome-wide copy number and miRNA global expression from 28 Latina women and identified a panel of 28 miRNAs associated with copy number alterations (CNAs). Four selected miRNAs (miR-141-3p, miR-150-5p, miR-182-5p, and miR-661) were validated in a subset of tumor and adjacent non-tumor tissue samples, with miR-182-5p being the most discriminatory among tissue groups (AUC value > 0.8). MiR-141-3p up-regulation was associated with increased cancer recurrence; miR-661 down-regulation with larger tumor size; and down-regulation of miR-150-5p with larger tumor size, high p53 expression, increased cancer recurrence, presence of distant metastasis, and deceased status. This study reinforces the importance of integration analysis of CNAs and miRNAs in TNBC, allowing for the identification of interactions among molecular mechanisms. Additionally, this study emphasizes the significance of considering the patients ancestral background when examining TNBC, as it can influence the relationship between intrinsic tumor molecular characteristics and clinical manifestations of the disease.

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Correlates of Adjuvant Therapy Attitudes in African American Breast Cancer Patients

Cited by 4 publications

References 41 publications

Influential factors in Black and White breast cancer survivors' beliefs about breast cancer

Influential factors in Black and White breast cancer survivors' beliefs about breast cancer

Assessing Perceived Discrimination as Reported by Black and White Women Diagnosed with Breast Cancer

Deregulated miRNA Expression in Triple-Negative Breast Cancer of Ancestral Genomic-Characterized Latina Patients

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