Correlates of atrial natriuretic factor in chronic renal failure

Tonolo, Giancarlo; Soro, A; Scardaccio, V.; Troffa, Chiara; Pazzola, Antonio; Manunta, Paolo; Melis, Maria Grazia; Pala, F.; Madeddu, Paolo; Rovasio, P. P.; Montorsi, Piero; Glorioso, Nicola

doi:10.1097/00004872-198900076-00115

Cited by 4 publications

(5 citation statements)

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“…Such factors may include peptides released from the N-terminus of the ANP prohormone which have been shown to have natriuretic effects both in animals and humans (Vesely et al, 1994). It is possible that the gradual increase in plasma ANP levels seen in aging humans represents a homeostatic adaptation to the reduced sensitivity in the kidney (Tonolo et al, 1989). Our findings disagree substantially with those of Depriest et al (1990), who found an enhanced natriuretic response to "low dose" ANP in old rats compared to young rats.…”

Section: Discussioncontrasting

confidence: 95%

“…It is tempting to speculate that these paracrine regulators of ANP secretion may be altered in aging. ANP in the plasma is elevated in aged individuals (Tonolo et al, 1989;Korytkowski and Ladenson, 1991), but this apparently occurs despite the fact that ANP secretion is less responsive to stimuli. This finding might suggest that the primary factor responsible for the elevated plasma ANP levels is a decrease in ANP metabolism resulting in a longer half-life (Yamada and Yoshida, 1989).…”

Section: Discussionmentioning

confidence: 96%

“…One of the earliest and most consistent findings concerning ANP and aging was that plasma levels are elevated with age in both humans (Tonolo et al, 1989) and rats (Korytkowski and Ladenson, 1991). Basal ANP secretion rate from isolated atria has been found to be both increased and depressed (Morrow et al, 1989;Tummala et al, 1992), whereas the ANP response to adrenergic stimuli has been reported to be increased (Tummala et al, 1992).…”

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confidence: 97%

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Alterations in Atrial Natriuretic Peptide (ANP) Secretion and Renal Effects in Aging

Pollack

Skvorak

Nazian

et al. 1997

The Journals of Gerontology Series A: Biological Sciences and M

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Aging is associated with hypertension and electrolyte disturbances. The purpose of this study was to determine the effect of aging upon secretion and renal actions of atrial natriuretic peptide (ANP). Rats were anesthetized and received tracheal, jugular vein, carotid artery, and bilateral uretheral catheterization. One set of young (2-3 mo) rats (Group 2, n = 9) and one set of old (18-21 mo) rats (Group 4, n = 7) received bilateral atrial appendectomies. Control young (Group 1, n = 8) and old (Group 3, n = 8) rats received a sham appendectomy. All rats were infused (iv) with 6% albumin in Krebs buffer, sufficient to increase blood volume by 15%. Finally, each rat was injected with ANP (1 microgram/kg). Sodium excretion rate (U(Na+)V) in response to volume expansion was significantly decreased in all groups compared to Group 1 (young control, p < .05). All groups demonstrated a striking increase in U(Na+)V with the ANP injection, but the response was greatest in young control rats when factored by body weight (p < .05). There were no significant differences in MAP between the groups, suggesting that the differences in U(Na+)V observed were not the result of hemodynamic factors. Isolated perfused atria from young (n = 9) and old (n = 8) rats were subjected to stretch and endothelin stimulation (50 nM). Atria from young rats showed a dramatic increase in ANP secretion in response to atrial stretch and a further marked increase in secretion in response to endothelin, whereas both of these responses were markedly attenuated in old rats (p < .05). These results suggested that the secretion and renal effects of ANP are impaired in aging. Changes in secretion and actions of ANP in aging could contribute to the development of hypertension or heart failure.

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Section: Discussioncontrasting

confidence: 95%

Section: Discussionmentioning

confidence: 96%

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confidence: 97%

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Alterations in Atrial Natriuretic Peptide (ANP) Secretion and Renal Effects in Aging

Pollack

Skvorak

Nazian

et al. 1997

The Journals of Gerontology Series A: Biological Sciences and M

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“…Senescence likely contributes to the development of hypertension as the senescent cells are present in hypertensive vessels (Oeseburg et al, 2009 ; Sueta et al, 2014 ). Plasma ANP is positively increased with ages in man and rat models (Korytkowski & Ladenson, 1991 ; Tonolo et al, 1989 ). It is, however, observed that the natriuretic or hypotensive response to exogenous ANP become decreased in elderly man and aged rodents (Lai et al, 2000 ; Mulkerrin et al, 1993 ; Pollack et al, 1997 ).…”

Section: Discussionmentioning

confidence: 99%

“…Plasma ANP is positively increased with ages in man and rat models (Korytkowski & Ladenson, 1991;Tonolo et al, 1989). It is, however, observed that the natriuretic or hypotensive response to exogenous ANP become decreased in elderly man and aged rodents (Lai et al, 2000;Mulkerrin et al, 1993;Pollack et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Chronological attenuation of NPRA/PKG/AMPK signaling promotes vascular aging and elevates blood pressure

et al. 2022

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Hypertension is common in elderly population. We designed to search comprehensively for genes that are chronologically shifted in their expressions and to define their contributions to vascular aging and hypertension. RNA sequencing was conducted to search for senescence‐shifted transcripts in human umbilical vein endothelial cells (HUVECs). Small interfering RNA (siRNA), small‐molecule drugs, CRISPR/Cas9 techniques, and imaging were used to determine genes' function and contributions to age‐related phenotypes of the endothelial cell and blood vessel. Of 25 genes enriched in the term of “regulation of blood pressure,” NPRA was changed most significantly. The decreased NPRA expression was replicated in aortas of aged mice. The knockdown of NPRA promoted HUVEC senescence and it decreased expressions of protein kinase cGMP‐dependent 1 (PKG), sirtuin 1 (SIRT1), and endothelial nitric oxide synthase (eNOS). Suppression of NPRA also decreased the phosphorylation of AMP‐activated protein kinase (AMPK) as well as the ratio of oxidized nicotinamide adenine dinucleotide (NAD+)/reduced nicotinamide adenine dinucleotide (NADH) but increased the production of reactive oxygen species (ROS). 8‐Br‐cGMP (analog of cGMP), or AICAR (AMPK activator), counteracted the observed changes in HUVECs. The Npr1+/− mice presented an elevated systolic blood pressure and their vessels became insensitive to endothelial‐dependent vasodilators. Further, vessels from Npr1+/− mice increased Cdkn1a but decreased eNos expressions. These phenotypes were rescued by intravenously administrated 8‐Br‐cGMP and viral overexpression of human PKG, respectively. In conclusion, we demonstrate NPRA/PKG/AMPK as a novel and critical signaling axis in the modulation of endothelial cell senescence, vascular aging, and hypertension.

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Atrial natriuretic factor and right atrial pressure in patients undergoing chronic haemodialysis

Tonolo

Scardaccio

Rocca³

et al. 1992

Acta Diabetol

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Correlates of atrial natriuretic factor in chronic renal failure

Cited by 4 publications

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Alterations in Atrial Natriuretic Peptide (ANP) Secretion and Renal Effects in Aging

Alterations in Atrial Natriuretic Peptide (ANP) Secretion and Renal Effects in Aging

Chronological attenuation of NPRA/PKG/AMPK signaling promotes vascular aging and elevates blood pressure

Atrial natriuretic factor and right atrial pressure in patients undergoing chronic haemodialysis

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