Correlates of breakthrough COVID-19 in vaccinated patients with systemic sclerosis: survival analysis from a multicentre international patient-reported survey

Ahmed, Sakir; Gupta, Latika; Kuwana, Masataka; Pauling, John D; Day, Jessica; Naveen, R; Joshi, Mrudula; Parodis, Ioannis; Sen, Parikshit; Jagtap, Kshitij; Nikiphorou, Elena; Saha, Sreoshy; Agarwal, Vishwesh; Chatterjee, Tulika; Lilleker, James B; Kardeş, Sinan; Milchert, Marcin; Gheita, Tamer A.; Salim, Babur; Velikova, Tsvetelina; Gracia‐Ramos, Abraham Edgar; Tan, Ai Lyn; Nune, Arvind; Cavagna, Lorenzo; Saavedra, Miguel Ángel; Shinjo, Samuel Katsuyuki; Ziadé, Nelly; Knitza, Johannes; Distler, Oliver; Wibowo, Suryo Anggoro Kusumo; Barman, Bhupen; Singh, Yogesh Preet; Ranjan, Rajiv; Jain, Avinash; Pandya, Sapan C; Pilania, Rakesh Kumar; Sharma, Aman; Manoj, Manesh; Gupta, Vikas; Kavadichanda, Chengappa G; Patro, Pradeepta Sekhar; Ajmani, Sajal; Phatak, Sanat; Goswami, Rudra Prosad; Chowdhury, Abhra Chandra; Mathew, Ashish Jacob; Shenoy, Padnamabha; Asranna, Ajay; Bommakanti, Keerthi Talari; Shukla, Anuj; Pande, Arunkumar R; Chandwar, Kunal; Cansu, Döndü Üsküdar; Wincup, Chris; Papa, Nicoletta Del; Sambataro, Gianluca; Atzeni, Fabiola; Govoni, Marcello; Parisi, Simone; Bocci, Elena Bartoloni; Sebastiani, Gian Domenico; Fusaro, Enrico; Sebastiani, Marco; Quartuccio, Luca; Franceschini, Franco; Sainaghi, Pier Paolo; Orsolini, Giovanni; Angelis, Rossella De; Danielli, Maria Giovanna; Venerito, Vincenzo; Traboco, Lisa S; Serrano, Jorge Rojas; Torre, Ignacio García‐De La; Tehozol, Erick Adrian Zamora; Loarce-Martos, Jesús; Prieto‐González, Sergio; Gil‐Vila, Albert; González, Raquel; Yoshida, Akira; Nakashima, Ran; Sato, Shinji; Kimura, Naoki; Kaneko, Yuko; Tomaras, Stylianos; Gromova, Margarita Aleksandrovna; Aharonov, Or; Hmamouchi, Ihsane; Hoff, Leonardo Santos; Giannini, Margherita; Maurier, F.; Campagne, Julien; Meyer, Alain; Nagy‐Vincze, Melinda; Langguth, Daman; Limaye, Vidya; Needham, Merrilee; Srivastav, Nilesh; Hudson, Marie; Landon‐Cardinal, Océane; Shaharir, Syahrul Sazliyana; Zuleta, Wilmer Gerardo Rojas; Silva, José António Pereira; Fonseca, João Eurico; Zimba, Olena; Chinoy, Hector; Aggarwal, Rohit; Agarwal, Vikas; Makol, Ashima

doi:10.1007/s00296-023-05433-z

Rheumatol Int

2023

DOI: 10.1007/s00296-023-05433-z

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Correlates of breakthrough COVID-19 in vaccinated patients with systemic sclerosis: survival analysis from a multicentre international patient-reported survey

Sakir Ahmed

Latika Gupta

Masataka Kuwana

et al.

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2024

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Breakthrough SARS-CoV-2 infection in fully vaccinated patients with systemic lupus erythematosus: results from the COVID-19 Vaccination in Autoimmune Disease (COVAD) study

Palazzo,

Lindblom,

Kihlgren Olsson

et al. 2024

Rheumatol Int

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Objective To determine the occurrence of breakthrough COVID-19 infections (BIs) in patients with systemic lupus erythematosus (SLE) compared with patients with other rheumatic autoimmune diseases (rAIDs), patients with non-rheumatic autoimmune diseases (nrAIDs), and healthy controls (HCs). Methods The study was based on data from 7035 fully vaccinated respondents to the online COVAD questionnaire with SLE (N = 852), rAIDs (N = 3098), or nrAIDs (N = 414), and HCs (N = 2671). BI was defined as COVID-19 infection occurring in individuals vaccinated with ≥ 2 doses (or 1 dose of J&J) ≥ 14 days after vaccination and not after 6 months since the last vaccine dose. Data were analysed using linear and logistic regression models. Results A total of 91/852 (10.7%) SLE patients reported at least one BI. The frequency of BIs in SLE patients was comparable to that among HCs (277/2671; p = 0.847) and patients with nrAID (39/414; p = 0.552) but higher than that among patients with other rAIDs (235/3098; p = 0.005). No demographic factors or treatments were associated with BIs in SLE patients (p ≥ 0.05 for all). Joint pain was more frequent in SLE patients than in HCs (odds ratio [OR]: 3.38; 95% confidence interval [CI]: 1.89–6.04; p < 0.001) or nrAID patients (OR: 2.44; 95% CI: 1.04–5.75; p = 0.041). Patient with SLE did not report a higher frequency of hospitalisation or need for advanced treatment for COVID-19 infection compared with disease controls and HCs, respectively. Conclusion COVID-19 vaccination conferred similar protection against COVID-19 infection in terms of frequency and severity in patients with SLE to that reported by healthy individuals.

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Breakthrough SARS-CoV-2 infection in fully vaccinated patients with systemic lupus erythematosus: results from the COVID-19 Vaccination in Autoimmune Disease (COVAD) study

Palazzo,

Lindblom,

Kihlgren Olsson

et al. 2024

Rheumatol Int

View full text Add to dashboard Cite

show abstract

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Correlates of breakthrough COVID-19 in vaccinated patients with systemic sclerosis: survival analysis from a multicentre international patient-reported survey

Cited by 1 publication

References 33 publications

Breakthrough SARS-CoV-2 infection in fully vaccinated patients with systemic lupus erythematosus: results from the COVID-19 Vaccination in Autoimmune Disease (COVAD) study

Breakthrough SARS-CoV-2 infection in fully vaccinated patients with systemic lupus erythematosus: results from the COVID-19 Vaccination in Autoimmune Disease (COVAD) study

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