The bystander intervention paradigm consists of upstanders preventing, mitigating, or responding to harm. The bystander intervention model (BIM) captures the decision-making process of bystanders: 1) notice harm; 2) interpret the situation; 3) assume responsibility; 4) select a strategy; and 5) take action (Latané & Darley, 1970). BIM has been applied to situations of safety (e.g., sexual assault, violence, cyber/bullying) and health (e.g., physical health, mental health). However, these bystander prevention opportunities do not reflect the full range of bystander opportunities, including promotion opportunities whereby upstanders can affirm desirable, safety-promoting or health-promoting behaviors. In this theoretical article, we adapt the prevention-oriented BIM by introducing promotion-oriented concepts associated with the intervention scope of promotion science, promotive focus of motivation science, and positive reinforcement of behavioral science. We propose the upstanding for promotion-prevention (UPP) model whereby promotion and prevention upstanders: 1) notice a promotion or a prevention opportunity; 2) interpret the situational degree of benefit or degree of harm; 3) assume responsibility as an ideal opportunity to enhance benefit or an obligation to stop harm; 4) select a promotion or prevention strategy; and 5) take action as an upstander using promotive or preventive prosocial bystander behavior. Additionally, we provide examples of UPP applications for safety (peace promotion – bullying prevention in schools) and health (health promotion – disease prevention in communities). Ultimately, we aim to advance a paradigm shift toward promotion upstanding, implicating bystander typologies, programs, and practices.