Correlates of childhood trauma in children and adolescents with bipolar disorder spectrum: A preliminary study

Cazala, Fadwa; Bauer, Isabelle E.; Meyer, Thomas D.; Spiker, Danielle; Kazimi, Iram; Zeni, Cristian Patrick; Zunta-Soares, Giovanna; Soares, Jair C.

doi:10.1016/j.jad.2018.12.007

Cited by 12 publications

(3 citation statements)

References 29 publications

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“…Children and Youths with Early-Onset BD:Four studies in children and youths with early-onset BD focused on associations between CT, in particular physical and sexual abuse, and clinical characteristics [75][76][77][78] (Table 1). Consistently among these studies, children and youths with early-onset BD were exposed to greater frequency and severity of CT than children and youths without any mental health condition.…”

Section: Findings From Children Youths and Young Adults Cross-sectiomentioning

confidence: 99%

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

Quidé¹,

Tozzi²,

Corcoran³

et al. 2020

NDT

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Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on retrospective and cross-sectional studies in adults with BD. The first objective of this selective review is to characterize the short-term effects of CT in the development of BD by focusing on studies in young people. The second objective is to describe the longer-term consequences of CT by considering studies with adult participants. This review first outlines the most prominent hypotheses linking CT exposure and the onset of BD. Then, it summarizes the psychological and biological risk factors implicated in the development of BD, followed by a discussion of original studies that investigated the role of CT in young people with early-onset BD, youths at increased risk of developing BD, or young people with BD with a focus on subclinical and clinical outcome measures. The review considers additional biological and psychological factors associated with a negative impact of CT on the long-term course of BD in later adulthood. Finally, we discuss how the integration of information of CT can improve ongoing early identification of BD and mitigate severe clinical expression in later adulthood.

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Section: Findings From Children Youths and Young Adults Cross-sectiomentioning

confidence: 99%

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

Quidé¹,

Tozzi²,

Corcoran³

et al. 2020

NDT

View full text Add to dashboard Cite

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“…The authors found that a history of physical abuse was associated with suicidal thoughts in females. In contrast, a history of emotional abuse was associated with greater violence against property in males (11).…”

Section: Introductionmentioning

confidence: 77%

“…Suicide risk in children and adolescents with BD was also associated with sleep disorders in the study of Stanley et al (10). Cazala et al (11) investigated the association between childhood trauma with irritability and aggressive and suicidal behaviors in pediatric participants with BD across sex. The authors found that a history of physical abuse was associated with suicidal thoughts in females.…”

Section: Introductionmentioning

confidence: 99%

The Greater Houston Area Bipolar Registry—Clinical and Neurobiological Trajectories of Children and Adolescents With Bipolar Disorders and High-Risk Unaffected Offspring

et al. 2021

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The aims of this article are to discuss the rationale, design, and procedures of the Greater Houston Area Bipolar Registry (HBR), which aims at contributing to the effort involved in the investigation of neurobiological mechanisms underlying bipolar disorder (BD) as well as to identify clinical and neurobiological markers able to predict BD clinical course. The article will also briefly discuss examples of other initiatives that have made fundamental contributions to the field. This will be a longitudinal study with participants aged 6–17 at the time of enrollment. Participants will be required to meet diagnostic criteria for BD, or to be offspring of a parent with BD. We will also enroll healthy controls. Besides clinical information, which includes neurocognitive performance, participants will be asked to provide blood and saliva samples as well as to perform neuroimaging exams at baseline and follow-ups. Several studies point to the existence of genetic, inflammatory, and brain imaging alterations between individuals at higher genetic risk for BD compared with healthy controls. Longitudinal designs have shown high conversion rates to BD among high-risk offspring, with attempts to identify clinical predictors of disease onset, as well as clarifying the burden associated with environmental stressors. The HBR will help in the worldwide effort investigating the clinical course and neurobiological mechanisms of affected and high-risk children and adolescents with BD.

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Violence in Major Mental Disorders

Amore

Aguglia

Santi

et al. 2019

Comprehensive Approach to Psychiatry

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Correlates of childhood trauma in children and adolescents with bipolar disorder spectrum: A preliminary study

Cited by 12 publications

References 29 publications

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

The Greater Houston Area Bipolar Registry—Clinical and Neurobiological Trajectories of Children and Adolescents With Bipolar Disorders and High-Risk Unaffected Offspring

Violence in Major Mental Disorders

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