Depression is a common problem among homeless men that may interfere with functional tasks, such as securing stable housing, obtaining employment, and accessing health services. Previous research on depression among homeless men has largely focused on current psychosocial resources, substance abuse, and past victimization. Guided by Ensel and Lin's life course stress process model, the authors examined whether distal stressors, including victimization and exposure to parent problems in childhood, contributed to men's depression above and beyond current (or proximal) stressors, such as substance abuse and health problems, and social resources. The sample consisted of 309 homeless men who had entered a federally funded emergency shelter. Using the Burns Depression Checklist, the authors found that one out of three men met the threshold for moderate to severe depression during the past week. The logistic regression showed that past exposure to parent problems was related to depression after accounting for current stressors and social resources (number of close adult relationships and whether their emotional support needs were met). Past victimization was not related to depression. To address men's depression, workers should concurrently provide services that meet men's basic needs (for example, housing) and address their relationship needs, including their need for emotional support. Previous research on depression among homeless men has largely focused on current psychosocial resources, substance abuse, and past victimization. In this study, we adopted a longer view and argued that it is important to take a life course perspective to understand depression among homeless men. Specifically, we relied on Ensel and Lin's (1996) life stress process model, which conceptualizes events or experiences that occurred in the distant past as distal stressors. Their research suggests that distal stressors can make an independent contribution to our understanding of depressive symptomology during adulthood above and beyond more recent or proximal stressors, and social resources.We hypothesized that distal stressors, including past victimization and exposure to parent problems during childhood (compare adverse childhood experiences [ACEs]), would increase the variance explained in homeless men's depressive symptoms above and beyond the variance explained by more recent stressors-such as substance abuse, physical health, and length of homelessness-and by fewer social resources. We conceptualized substance abuse, physical health problems, and greater duration of homelessness as proximal stressors because they are current conditions, generally viewed as undesirable, and are likely to create a sense of being out of control with a high potential to contribute to stress. After testing the direct effect of distal stressors, proximal stressors, and social resources, controlling for several demographic factors, on depressive symptoms, we determined whether social resources have a buffering or moderating effect on the relation between dist...