Correlates of fatigue in survivors of breast cancer

Mast, Merle E.

doi:10.1097/00002820-199804000-00007

Cited by 80 publications

(58 citation statements)

References 24 publications

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“…However, in a recent study fatigue has been shown to be associated with sleep quality but not with sleep latency [19]. An association between fatigue and the severity of pain has been confirmed in several research studies [8,21,27,30]. The contribution of pain to fatigue in cancer patients might be explained in several ways.…”

Section: Discussionmentioning

confidence: 94%

Factors predicting fatigue in breast cancer patients

Haghighat

Akbari

Holakouei

et al. 2003

Supportive Care in Cancer

101

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A prospective study was designed to investigate the factors predicting fatigue in breast cancer patients using the Cancer Fatigue Scale (CFS) in addition to the Hospital Anxiety and Depression Scale (HADS) and a questionnaire containing items on demographic and clinical data, and measures of patients' physical symptoms. The CFS measures total fatigue score ranging from 0 (lowest level) to 60 (highest level) and contains three subscales namely: physical, affective and cognitive fatigue. The questionnaires were administered to a consecutive sample of breast cancer patients attending the Iranian Center for Breast Cancer either for their treatment or follow-up examination. In all, 112 patients were studied. The mean age of the respondents was 45.7 years (SD11.0). Most had stage II breast cancer (67%) and had completed their initial treatment (45%). The mean total fatigue score of the patients was 18.7 (SD 13.5) and overall 49% reported experiencing fatigue to some degree (from quite a bit to very much). Severe anxiety and depression was reported by 16% and 32%, respectively. The regression analysis revealed that fatigue was predicted by depression ( P=0.003), pain ( P=0.005), current tamoxifen use ( P=0.001), undergoing mastectomy ( P=0.03) and anxiety ( P=0.04). The other variables studied did not emerge as significant predictors of fatigue in the regression analysis. The study findings suggest that in comparison to treatment factors, physical and psychological symptoms have a more important role in cancer-related fatigue and that fatigue should be recognized and managed even before commencing breast cancer treatment.

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Section: Discussionmentioning

confidence: 94%

Factors predicting fatigue in breast cancer patients

Haghighat

Akbari

Holakouei

et al. 2003

Supportive Care in Cancer

101

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“…Earlier studies on possible mechanisms have found no consistent association between fatigue and stage of disease, extent of treatment, time since treatment completion, type of surgery or use of tamoxifen. 5,7,8 Some studies have investigated the role of the immune system and, in particular, the role of cytokines in relation to fatigue in breast cancer survivors. [9][10][11][12][13][14][15] Fatigued breast cancer survivors have been shown to have significantly higher levels of proinflammatory cytokines and circulating T lymphocytes compared with non-fatigued survivors.…”

Section: Introductionmentioning

confidence: 99%

Alterations of gene expression in blood cells associated with chronic fatigue in breast cancer survivors

et al. 2009

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Fatigue is one of the most frequent complaints among breast cancer survivors. However, mechanisms underlying persisting fatigue after end of treatment are poorly understood. To explore whether biological processes underlying persistent fatigue can affect gene expression of blood cells, genome-wide expression analyses were performed on whole blood samples from breast cancer survivors classified as chronic fatigued 2-6 years after diagnosis. Non-fatigued survivors served as controls. Several gene sets involved in plasma-and B-cell pathways differed between the chronic fatigued and the non-fatigued, suggesting that a dysregulation in these pathways is associated with chronic fatigue and that a B-cell-mediated inflammatory process might underlie fatigue. The chronic fatigued also had a higher level of leucocytes, lymphocytes and neutrophiles compared with the non-fatigued, thus further indicating that an activation of the immune system plays a role in the biology of chronic fatigue in breast cancer survivors.

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“…192,203 Emerging evidence suggests that fatigue persists even after acute treatment is completed, 214 and correlates with the use of chemotherapy, irrespective of the time since treatment. 215 …”

Section: Fatiguementioning

confidence: 99%

Broken doctor–patient relationships: why won't they listen?

Jefford

Zalcberg

2014

Medical Journal of Australia

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Every user of this rescinded publication acknowledges that the information contained in it may not be accurate, complete or of relevance to the user's purposes. The user undertakes the responsibility for assessing the accuracy, completeness and relevance of the contents of this rescinded publication, including seeking independent verification of information sought to be relied upon for the user's purposes.Every user of this rescinded publication is responsible for ensuring that each printed version contains this disclaimer notice, including the date of recision and the date of downloading the archived Internet version. This work is copyright.Apart from any use as permitted under the Copyright Act 1968, no part may be reproduced by any process without prior written permission from National Breast Cancer Centre. Requests and enquiries concerning reproduction and rights should be addressed to the Copyright Office, National Breast Cancer Centre, Locked Bag 16, Camperdown NSW 1450, Australia.Website:www.nbcc.org.au Email: directorate@nbcc.org.au These guidelines were approved by the National Health and Medical Research Council at its 147th Session on 10 April 2003, under section 14A of the National Health and Medical Research Council Act 1992.Approval for the guidelines by NHMRC is granted for a period not exceeding five years, at which date the approval expires.The NHMRC expects that all guidelines will be reviewed no less than once every five years. Readers should check with the National Breast Cancer Centre for any reviews or updates of these guidelines. RESCINDEDThe strategic intent of the NHMRC is to provide leadership and work with other relevant organisations to improve the health of all Australians by:• fostering and supporting a high quality and internationally recognised research base; • providing evidence based advice; • applying research evidence to health issues thus translating research into better health practice and outcomes; and • promoting informed debate on health and medical research, health ethics and related issues.This document is a general guide to appropriate practice, to be followed subject to the clinician's judgement and the patient's preference in each individual case.The guidelines are designed to provide information to assist decision-making and are based on the best evidence available at the time of publication. C O N T E N T S L I S T O F TA B L E S L I S T O F F I G U R E S F O R E W O R DOptimal care of the patient with cancer incorporates effective physical and psychological care.There are currently several clinical practice guidelines available documenting evidence-based information and treatment recommendations for the physical care of people with cancer, many of which are also available in consumer versions. Some of these treatment guidelines include chapters devoted to psychosocial care.People with cancer suffer significant emotional morbidity. In addition to the distress, fear and grief consequent upon diagnosis, up to 30% experience clinically significant anxiety disorde...

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Correlates of fatigue in survivors of breast cancer

Cited by 80 publications

References 24 publications

Factors predicting fatigue in breast cancer patients

Factors predicting fatigue in breast cancer patients

Alterations of gene expression in blood cells associated with chronic fatigue in breast cancer survivors

Broken doctor–patient relationships: why won't they listen?

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