Correlates of fear of cancer recurrence in women with ductal carcinoma in situ and early invasive breast cancer

Liu, Ying; Pérez, María; Schootman, Mario; Aft, Rebecca; Gillanders, William E.; Jeffe, Donna B.

doi:10.1007/s10549-011-1551-x

Cited by 94 publications

(114 citation statements)

References 54 publications

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“…Indeed, in cancer survivors, the presence and the severity of physical symptoms have consistently been associated with greater FCR [8,22,23,26,40] and have been found to be major triggers of intrusive thoughts associated with FCR [4,41]. The relationship with GAD, characterized by a persistent and excessive worry about health, the future, or other real-life problems was also expected.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, some studies [3] assessing depression symptoms with a self-report questionnaire observed a statistically significant association with FCR (r=.19 to .57). Moreover, Liu et al [26] reported that breast cancer patients with clinical levels of depression had higher FCR levels than those without depression. Despite the possible overlap between FCR and psychiatric disorders, no study has yet evaluated the comorbidity of FCR with a large spectrum of psychiatric disorders.…”

Section: Introductionmentioning

confidence: 99%

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Screening and comorbidity of clinical levels of fear of cancer recurrence

2015

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Screening and comorbidity of clinical levels of fear of cancer recurrence

2015

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“…It is possible that psychological distress in young BCS with children leads to greater illness intrusiveness and fear of cancer recurrence. Indeed, psychological distress has been shown to prospectively influence fear of cancer recurrence [47,48]; however, this may not be the case for illness intrusiveness. Although illness intrusiveness and psychological distress frequently co-occur [31], evidence suggests that illness intrusiveness exacerbates psychological distress and not the reverse [49].…”

Section: Discussionmentioning

confidence: 99%

Motherhood and Well-Being in Young Breast Cancer Survivors

Wan

Arès

Gareau

et al. 2018

Breast Cancer Manag.

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Practice pointsr 15 elements of well-being were identified in the literature and exploratory factor analysis revealed a four-factor structure of well-being in breast cancer survivors (BCS): recurrence worries, physical health, psychological adjustment and illness intrusiveness. r Analyses revealed that there was a stronger relationship between psychological adjustment and illness intrusiveness for young BCS with children. r Psychological distress (i.e., lack of psychological adjustment), illness intrusiveness and fear of recurrence co-occurred more frequently in young BCS with children than in BCS without children, thus potentially compromising their well-being. r Our findings indicate that young BCS with children are most in need of screening and interventions in these areas, and such initiatives should be incorporated in their medical care and visits.Aim: This exploratory study aimed to examine differences in well-being between young breast cancer survivors (BCS) with and without children. Materials & methods: Participants (n = 816) completed an online survey relating to quality of life, illness intrusiveness, fear of cancer recurrence, stress and social support. Results: Exploratory and confirmatory factor analyses revealed similar models of well-being between both groups, but with a stronger relationship between psychological adjustment and illness intrusiveness for BCS with children (r = -0.779, 95% CI: -0.711, -0.848 vs r = -0.525, 95% CI: -0.423, -0.627). Conclusion: Parenting compromises the overall well-being of young BCS with children and they would therefore benefit from interventions and social and oncological support programs, especially for those caring for minor children. In a recent population-based study of cancer survivors, Weaver et al. [1] examined the prevalence of parental cancer via the United States National Health Interview Survey (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007); they identified 13,385 adults with a history of cancer with one or more minor children under the age of 18. Only adults with minor children who were diagnosed with cancer less than 2 years before the survey were included in the study (n = 1769), but of that subset, approximately 85% of them were diagnosed under the age of 45 [1]. In the USA, the average age of breast cancer diagnosis is 61 years for women; but 11% of all new cases occur in women under the age of 45 [2]. Following these guidelines, we operationalized 'young breast cancer survivors' as individuals with a diagnosis of cancer under the age of 45 and who were currently considered cancer free [2]. A diagnosis of breast cancer at a young age can interfere with the demands of early adulthood and the short-and long-term effects of treatment can be especially problematic for this group [3]. Young breast cancer survivors with children (BCS with children) may, therefore, be a particularly vulnerable group because the stressors that accompany motherhood may compound the difficulties Breast Cancer Manag. (Epub ahead of print)

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“…In Table 2 Anxiety and depression of patients with ductal carcinoma in situ and early-stage invasive breast cancer according to Hospital Anxiety and Depression Scale (HADS) HADS domain Group the same study, women with DCIS and early-IBC reported similar distress levels as the reference population six months after treatment [13]. Besides anxiety and depressive symptoms, fear of breast cancer recurrence and exaggerated risk perception was similar in patients with DCIS and those with stage 1 invasive breast cancer and persisted for years after diagnosis [14,29]. Although DCIS patients were aware of their diagnosis and significantly better able to differentiate between in situ and invasive carcinoma than women with early-IBC, they estimated their risk of recurrence of (invasive) breast disease similarly high as patients with invasive cancer [15,30,31].…”

Section: Discussionmentioning

confidence: 85%

“…Historically, DCIS patients have consistently reported similar levels of fear of breast cancer recurrence and death from breast cancer as women with early-IBC, which can cause substantial psychological distress [11][12][13][14][15][16][17]. Today, the excellent survival of DCIS is extensively discussed with the patient by the multidisciplinary team, and innumerable online documentation is available to patients on this matter.…”

Section: Introductionmentioning

confidence: 99%

Severe depression more common in patients with ductal carcinoma in situ than early-stage invasive breast cancer patients

Gregorowitsch

Bongard

Young‐Afat

et al. 2017

Breast Cancer Res Treat

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Purpose Ductal carcinoma in situ (DCIS) is associated with an excellent prognosis; historical studies have shown similar levels of psychological distress in patients with DCIS and with early-stage invasive breast cancer (early-IBC). It is suggested that these results might have led to better patient education about prognosis after DCIS. This study reports the current levels of anxiety, depression, and health-related quality of life (HRQoL) in DCIS and early-IBC patients. Methods DCIS (n = 89) and early-IBC patients, T1-2N0, (n = 361) were selected from the UMBRELLA breast cancer cohort. Patient-reported outcomes were prospectively collected before the start of adjuvant radiotherapy (baseline) and at 3, 6, 12, 18, and 24 months thereafter. Mixed models were used to compare differences in levels of anxiety, depression, and HRQoL between DCIS and early-IBC patients.Results DCIS and early-IBC patients reported similar levels of anxiety, which were highest at baseline. Depression scores were comparable between groups, also after stratification by use of adjuvant chemotherapy. The proportion of patients reporting high-risk depression scores (i.e., Hospital Anxiety and Depression Sale score [8) was significantly higher among patients with DCIS at 6, 12 and 18 months, and this proportion increased over the first 18 months. Health-related quality of life was comparable between both groups. Conclusion Severe depression scores are more common in DCIS patients, despite their excellent prognosis. These results suggest that further improvement of patient education and effective patient doctor communication about the prognostic differences between patients with DCIS and invasive breast cancer is still highly needed.

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Correlates of fear of cancer recurrence in women with ductal carcinoma in situ and early invasive breast cancer

Cited by 94 publications

References 54 publications

Screening and comorbidity of clinical levels of fear of cancer recurrence

Screening and comorbidity of clinical levels of fear of cancer recurrence

Motherhood and Well-Being in Young Breast Cancer Survivors

Severe depression more common in patients with ductal carcinoma in situ than early-stage invasive breast cancer patients

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