Correlates of high density lipoprotein cholesterol and apolipoprotein A-I levels in children. The Bogalusa Heart Study.

Freedman, David S.; Srinivasan, Sathanur R.; Shear, Charles L.; Webber, Larry S.; Chiang, Yu Kun; Berenson, Gerald S.

doi:10.1161/01.atv.7.4.354

Cited by 11 publications

(2 citation statements)

References 32 publications

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“…1. As reported previously [22,23] the correlation coefficient between HDL cholesterol and apo A-I was strong (0.60) ( Table 2), but the variability of HDL cholesterol at each concentration of apo A-I was marked. Therefore, there must be significant interindividual variation in the composition of HDL particles among normolipidaemic young men.…”

Section: Resultssupporting

confidence: 85%

Plasma concentrations of apolipoprotein A‐I containing particles in normolipidaemic young men

Luc

Parra

Zylberberg

et al. 1991

Eur J Clin Investigation

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Low levels of plasma high-density lipoprotein (HDL)-cholesterol and apolipoprotein (apo)-A-I are associated with premature coronary heart disease. However, particles in the density range of HDL are heterogeneous. Two main types of apo A-I-containing particles can be identified, one species containing both apo A-I and apo A-II (Lp A-I:A-II) and the other apo A-I but no apo-A-II (Lp A-I). This study was designed to measure HDL cholesterol, apo A-I, and, using a new procedure, Lp A-I in 233 healthy normolipidaemic young men (cholesterol less than 250 mg dl-1 and triglycerides less than 200 mg dl-1). Among these subjects, the composition of HDL was very variable as indicated by the 10th and the 90th percentiles of the HDL-cholesterol/apo A-I ratios which were 0.32 and 0.49, respectively. The 10th and 90th percentiles of apo A-I and Lp A-I:A-II were 126 and 167 mg dl-1 and 83 and 116 mg dl-1, respectively. On the other hand, Lp A-I showed a much larger variation, the 10th and 90th percentiles being at 33 and 62 mg dl-1, respectively. The distribution of individual values of Lp A-I showed that this fraction of apo A-I-containing particles was very variable among subjects, the Lp A-I/apo A-I ratio extending from 0.18 to 0.58. Triglycerides, Lp A-I and Lp A-I:A-II were correlated with HDL cholesterol, but no correlation between apo A-I containing subfractions and plasma triglycerides was noticed. Since preliminary results from angiographic and clinical studies show that Lp A-I could exert a protective role for atherosclerosis, it would seem that the measurement of Lp A-I might help in the future to characterize better the individual's risk for atherosclerosis.

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Section: Resultssupporting

confidence: 85%

Plasma concentrations of apolipoprotein A‐I containing particles in normolipidaemic young men

Luc

Parra

Zylberberg

et al. 1991

Eur J Clin Investigation

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show abstract

“…Low apoA-I, contained in both LpA-I and LpA-I:A-II, is also known to be predictive of myocardial infarction (13). In 5-17-y-old children in Bogalusa, Louisiana, the association between obesity and HDL-C was stronger than with apoA-I and appeared to be secondary to increased triglyceride (14). This was supported by the observation that increases in triglyceride alter the relative cholesterol content of HDL particles (15).…”

mentioning

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Body Mass Index and High-Density Lipoproteins in Cherokee Indian Children and Adolescents

et al. 2005

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The Relationship Between Sex Hormones and High-Density Lipoprotein Cholesterol Levels in Healthy Adult Men

Duell¹,

Bierman

1990

Arch Intern Med

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Correlates of high density lipoprotein cholesterol and apolipoprotein A-I levels in children. The Bogalusa Heart Study.

Abstract: Levels of high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (apo

Cited by 11 publications

References 32 publications

Plasma concentrations of apolipoprotein A‐I containing particles in normolipidaemic young men

Plasma concentrations of apolipoprotein A‐I containing particles in normolipidaemic young men

Body Mass Index and High-Density Lipoproteins in Cherokee Indian Children and Adolescents

The Relationship Between Sex Hormones and High-Density Lipoprotein Cholesterol Levels in Healthy Adult Men

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