Correlates of Human Papillomavirus Viral Load with Infection Site in Asymptomatic Men

Flores, Roberto; Lu, Binfeng; Nielson, Carrie M.; Abrahamsen, Martha; Wolf, Kyle J.; Lee, Ji Hyun; Harris, Robin B.; Giuliano, Anna R.

doi:10.1158/1055-9965.epi-08-0467

Cited by 36 publications

(30 citation statements)

References 24 publications

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“…In addition, previous studies demonstrated that about half of invasive penile SCC and more than 90% of anal intraepithelial neoplasias are positive for a high-risk HPV type, of which HPV-16 was by far the predominant type [50,51,52]. Flores et al [53] observed significant positive correlations in HPV-16 viral load between infection sites in close proximity, such as the perianal and anal canal or the perianal area and scrotum, or the sites in regular contact with each other at a resting position, such as the scrotum and glans/corona or the scrotum and penile shaft. This observation suggests that previously HPV-uninfected genital sites may be inoculated by existing infections from proximal anatomic sites by direct contact between the sites and facilitated by environmental factors such as humidity, temperature and possibly poor hygiene.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

et al. 2009

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Background: To the best of our knowledge, only 52 cases of squamous cell carcinoma (SCC) complicating hidradenitis suppurativa (HS) have been reported since 1958. We describe 13 new cases. Methods: We propose a clinical and histological analysis of our cases. We include these results in a review of previously reported cases to analyze a total of 65 patients. In our series of 13 cases, we also investigate the presence of human papillomavirus (HPV) in tumor samples, by polymerase chain reaction (PCR) on paraffin-embedded material. Results: Malignant transformation affects mainly men with a long-term history of genitoanal HS. Although our cases were 7 well-differentiated carcinomas and 6 verrucous carcinomas, lymphatic and visceral metastasis occurred in 2 and 3 cases, respectively. With PCR, we demonstrated presence of HPV in genitoanal tumoral lesions, principally HPV-16. Conclusion: SCC complicating HS evolves poorly, despite a good histological prognosis. Our results sustain the implication of HPV in the malignant transformation of HS.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

et al. 2009

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“…Evidence suggests a higher viral load in the penile shaft than the glans/corona; 32 a higher viral load implies a higher risk of transmission to a sex partner. While incident HPV infection was detected more frequently in shaft/scrotum specimens than in glans or urine specimens of both circumcised and uncircumcised men in our study, the incidence of shaft/scrotum infections was higher in circumcised relative to uncircumcised men.…”

Section: Discussionmentioning

confidence: 99%

Circumcision and Acquisition of Human Papillomavirus Infection in Young Men

Vanbuskirk¹,

Winer²,

Hughes³

et al. 2011

Sexually Transmitted Diseases

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Background The role of circumcision in male HPV acquisition is not clear. Methods Male university students (18–20 years of age) were recruited from 2003–2009 and followed tri-annually. Shaft/scrotum, glans, and urine samples were tested for 37 alpha HPV genotypes. Cox proportional hazards methods were used to evaluate the association between circumcision and HPV acquisition. Logistic regression was used to assess whether number of genital sites infected at incident HPV detection or site of incident detection varied by circumcision status. Results In 477 men, rates of acquiring clinically-relevant HPV types (high-risk types plus types 6 and 11) did not differ significantly by circumcision status (hazard ratio [HR] for uncircumcised relative to circumcised subjects: 0.9[95%CI:0.7–1.2]). However, compared to circumcised men, uncircumcised men were 10.1 (95%CI:2.9–35.6) times more likely to have the same HPV type detected in all 3 genital specimens than in a single genital specimen and were 2.7 (95%CI:1.6–4.5) times more likely to have an HPV-positive urine or glans specimen at first detection. Conclusions While the likelihood of HPV acquisition did not differ by circumcision status, uncircumcised men were more likely than circumcised men to have infections detected at multiple genital sites, which may have implications for HPV transmission.

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“…Additionally, HR-HPV persistence among heterosexual men is associated with HIV infection, smoking, increased number of lifetime sexual partners, absence of male circumcision, and younger age 10–13. Higher viral load among men is associated with detection of HR-HPV at multiple penile sites14 and flat penile lesions 15 16. It has also been shown that HR-HPV transmission to female partners is associated with higher male viral loads 17.…”

Section: Introductionmentioning

confidence: 99%

High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men

et al. 2014

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Objectives High-risk human papillomavirus (HR-HPV) viral load is associated with HR-HPV transmission and HR-HPV persistence in women. It is unknown whether HR-HPV viral load is associated with persistence in HIV-negative or HIV-positive men. Methods HR-HPV viral load and persistence were evaluated among 703 HIV-negative and 233 HIV-positive heterosexual men who participated in a male circumcision trial in Rakai, Uganda. Penile swabs were tested at baseline and 6, 12 and 24 months for HR-HPV using the Roche HPV Linear Array, which provides a semi-quantitative measure of HPV shedding by hybridization band intensity (graded:1–4). Prevalence risk ratios (PRR) were used to estimate the association between HR-HPV viral load and persistent detection of HR-HPV. Results HR-HPV genotypes with high viral load (grade:3–4) at baseline were more likely to persist than HR-HPV genotypes with low viral load (grade:1–2) among HIV-negative men (month 6: adjPRR=1.83, 95%CI:1.32–2.52; month 12: adjPRR=2.01, 95%CI:1.42–3.11), and HIV-positive men (month 6: adjPRR=1.33, 95%CI:1.06–1.67; month 12: adjPRR=1.73, 95%CI:1.18–2.54). Long-term persistence of HR-HPV was more frequent among HIV-positive men compared to HIV-negative men (month 24: adjPRR=2.27, 95%CI: 1.47–3.51). Persistence of newly detected HR-HPV at the 6 and 12 month visits with high viral load were also more likely to persist to 24 months than HR-HPV with low viral load among HIV-negative men (adjPRR=1.67, 95%CI 0.88–3.16). Conclusions HR-HPV genotypes with high viral load are more likely to persist among HIV-negative and HIV-positive men, though persistence was more common among HIV-positive men overall. The results may explain the association between high HR-HPV viral load and HR-HPV transmission.

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Correlates of Human Papillomavirus Viral Load with Infection Site in Asymptomatic Men

Cited by 36 publications

References 24 publications

Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

Clinicopathological Study of 13 Cases of Squamous Cell Carcinoma Complicating Hidradenitis Suppurativa

Circumcision and Acquisition of Human Papillomavirus Infection in Young Men

High-risk human papillomavirus viral load and persistence among heterosexual HIV-negative and HIV-positive men

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