Correlates of infection with<i>Helicobacter pylori</i>positive and negative cytotoxin-associated gene A phenotypes among Arab and Jewish residents of Jerusalem

Muhsen, Khitam; Sinnereich, R.; Beer-Davidson, Gany; Nassar, Hisham; Ahmed, Waquaruddin; Cohen, Dani; Kark, J. D.

doi:10.1017/s0950268819001456

Cited by 5 publications

(8 citation statements)

References 33 publications

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“…The prevalence of H. pylori infection in our study was 35% (42% CagA positive). This concurs with our previous findings in the Israeli population 23,31 . As expected, children with H. pylori positivity had higher serum PGI and PGII levels and a lower PGI:PGII ratio than did children with H. pylori negativity 15 .…”

Section: Discussionsupporting

confidence: 92%

Associations of Helicobacter pylori seropositivity and gastric inflammation with pediatric asthma

Elias

Nasrallah

Khoury

et al. 2020

Pediatric Pulmonology

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Objective Controversy exists regarding an association between Helicobacter pylori infection and asthma in children. We examined the hypotheses of inverse associations of H. pylori seroprevalence and pepsinogen (PG) levels, as markers of gastric inflammation, with asthma in children. Methods A hospital‐based case‐control study was conducted among children aged 4.8 to 17.3 years in Israel. Confirmed asthma cases (n = 75) were recruited through a pulmonary clinic, and controls (n = 160) without asthma were enrolled. Using enzyme‐linked immunosorbent assays we measured the presence of H. pylori immunoglobulin G (IgG) antibodies, IgG antibodies to cytotoxin‐associated gene A antigen (CagA) (virulent factor), serum PG levels and exposure to other enteric pathogens (Shigella flexneri). Multivariable logistic regression models were applied. Results H. pylori IgG seropositivity was 25% and 40% among cases and controls, respectively (P = .03). H. pylori CagA IgG seropositivity was associated with reduced risk of asthma (adjusted odds ratio [OR], 0.33 [95% CI, 0.11‐0.95] but not for the CagA negative serology (adjusted OR, 0.70 [95% CI, 0.32‐1.54]). Children who were H. pylori seropositive with a PGI:PGII of ≤6.78 (severe gastric inflammation) had a lower likelihood of asthma (adjusted OR, 0.31 [95% CI, 0.10‐0.89]) than did seronegative children. Exposure to Shigella flexneri did not differ between cases and controls, nor according to H. pylori seropositivity. Among the asthmatic children, pulmonary function did not differ according to H. pylori seropositivity. Conclusions H. pylori infection and its related gastric inflammation may have a protective role in the risk of pediatric asthma and further research into a potential causal pathway is required.

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Section: Discussionsupporting

confidence: 92%

Associations of Helicobacter pylori seropositivity and gastric inflammation with pediatric asthma

Elias

Nasrallah

Khoury

et al. 2020

Pediatric Pulmonology

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“…H. pylori IgG antibody sero-prevalence was 83.3% (95% confidence interval (CI) 80.0-85.5%) and 61.4% (95% CI 57.7-65.0%) among Arabs and Jews, respectively. Among H. pylori positives, the respective cagA IgG antibody sero-positivity was 42.3% (95% CI 38.9-45.8%) and 32.5% (95% CI 28.2-37.1%) [44].…”

Section: Prevalence Of H Pylori Genotypes and Their Correlation Withmentioning

confidence: 97%

Prevalence of Helicobacter pylori Infection and Diagnostic Methods in the Middle East and North Africa Region

et al. 2020

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Background and Objectives: Helicobacter pylori (H. pylori) infection is common worldwide and may cause gastroduodenal complications, including cancer. In this review, we examine the prevalence and distribution of various H. pylori genotypes and the risk factors for H. pylori infection, particularly in the Middle East and North Africa (MENA) region. We also introduce different global screening methods and guidelines and compare them to those currently in use in the MENA region. Materials and Methods: We searched the Google Scholar, PubMed, and Saudi Digital Library (SDL) databases for clinical trials and articles published in English. The data collection was mainly focused on MENA countries. However, for H. pylori genotypes and diagnostic methods, studies conducted in other regions or reporting global practices and guidelines were also included to allow a comparison with those in the MENA region. We also included studies examining the prevalence of H. pylori infection in healthy participants. Results: H. pylori infection is highly prevalent in the MENA region, mainly because of the accumulation of risk factors in developing countries. Herein, we highlight a lack of good quality studies on the prevalence of various H. pylori genotypes in the MENA region as well as a need for standard diagnostic methods and screening guidelines. Due to the complications associated with H. pylori, we recommend routine screening for H. pylori infection in all gastroenterology patients admitted in the MENA region. Conclusion: Concerted effort will first be required to validate affordable, non-invasive, and accurate diagnostic methods and to establish local guidelines with adapted cut-off values for the interpretation of the test results.

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“…Interestingly, Muhsen et al [ 14 ], who also investigated H. pylori isolates in Arab and Jewish populations, demonstrated higher Cag A IgG antibodies in the Arab population. Another study, performed in Israeli children and adolescents, found higher H. pylori seroprevalence among Arab participants as compared to Jewish participants[ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of Helicobacter pylori virulence markers on clinical outcomes in adult populations

Roshrosh¹,

Rohana²,

Azrad³

et al. 2023

World J Gastroenterol

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BACKGROUND In recent years, associations between specific virulence markers of Helicobacter pylori ( H. pylori ) and gastrointestinal disorders have been suggested. AIM To investigate the presence of virulence factors including vacuolating cytotoxin A genotypes ( s1m1 , s1m2 , s2m1 , and s2m2 ), cytotoxin-associated gene A ( Cag A), and urease activity in H. pylori strains isolated from Arab and Jewish populations in northern Israel and to assess associations between these factors and patients’ demographics and clinical outcomes. METHODS Patients ( n = 108) who underwent gastroscopy at the Baruch Padeh Medical Center, Poriya due to symptomatic gastroduodenal pathologies as part of H. pylori diagnosis were enrolled in the study. Gastric biopsy specimens were collected from the antrum of the stomach. Clinical condition was assessed by clinical pathology tests. Bacteria were isolated on modified BD Helicobacter Agar (BD Diagnostics, Sparks, MD, United States). Bacterial DNA was extracted, and PCR was performed to detect Cag A and vacuolating cytotoxin A genes. Urease activity was assessed using a rapid urease test. RESULTS A significant correlation was found between disease severity and patient ethnicity ( P = 0.002). A significant correlation was found between Cag A presence and the s1m1 genotype ( P = 0.02), which is considered the most virulent genotype. Further, a higher level of urease activity was associated with isolates originating from the Jewish population. Moreover, higher urease activity levels were measured among Cag A-/ s1m1 and Cag A-/ s2m2 isolates. CONCLUSION Our study highlights the importance of incorporating molecular methods for detection of virulence markers of H. pylori in order to tailor optimal treatments for each patient. Further investigation should be performed regarding associations between H. pylori virulence factors and ethnicity.

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Correlates of infection withHelicobacter pyloripositive and negative cytotoxin-associated gene A phenotypes among Arab and Jewish residents of Jerusalem

Cited by 5 publications

References 33 publications

Associations of Helicobacter pylori seropositivity and gastric inflammation with pediatric asthma

Associations of Helicobacter pylori seropositivity and gastric inflammation with pediatric asthma

Prevalence of Helicobacter pylori Infection and Diagnostic Methods in the Middle East and North Africa Region

Impact of Helicobacter pylori virulence markers on clinical outcomes in adult populations

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