Correlates of Metabolic Syndrome in Patients with Schizophrenia: An Exploratory Study

Nebhinani, Naresh; Tripathi, Swapnil; Suthar, Navratan; Pareek, V.; Purohit, Priyanka; Sharma, Praveen

doi:10.1007/s12291-020-00912-7

Cited by 2 publications

(4 citation statements)

References 18 publications

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“…Similar trends were reported earlier in general population [ 7 ] and patients with schizophrenia. [ 8 ] In line with earlier studies, [ 8 , 15 ] we also found BMI, obesity, and RBC count as significant correlates for MS.…”

Section: Discussionsupporting

confidence: 92%

“…One-sixth of the patients were smokers, which are similar to figures reported in earlier study from northern India (18%), [6] but relatively half as compared to the study from Singapore (33%). [4] MS prevalence was 39.6% in index study, which is close to figures reported in earlier studies from same center (34.5%), [15] other center of Northern India (36.4%), [6] and systematic review and meta-analysis (33.4%). [1] In addition, about half of the patients had metabolic abnormalities (fulfilled one or two components of MS criteria), which depicts their greater vulnerability to develop MS.…”

Section: Discussionsupporting

confidence: 86%

“…MS prevalence was 39.6% in index study, which is close to figures reported in earlier studies from same center (34.5%), [ 15 ] other center of Northern India (36.4%), [ 6 ] and systematic review and meta-analysis (33.4%). [ 1 ] In addition, about half of the patients had metabolic abnormalities (fulfilled one or two components of MS criteria), which depicts their greater vulnerability to develop MS.…”

Section: Discussionsupporting

confidence: 86%

“…About half of the patients were obese as per Asian Indian cutoff (BMI ≥25). [ 14 ] Earlier studies [ 6 , 15 ] have reported abnormal waist circumference/abdominal obesity as most common abnormality and similar rates of obesity in patients with schizophrenia. One-sixth of the patients were smokers, which are similar to figures reported in earlier study from northern India (18%), [ 6 ] but relatively half as compared to the study from Singapore (33%).…”

Section: Discussionmentioning

confidence: 99%

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Vascular age, cardiovascular disease risk factors, and hematological parameters in patients with Schizophrenia: An exploratory study

Vyas

Nebhinani²,

Suthar³

et al. 2022

JNRP

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Objectives: Patients with schizophrenia have shortened life expectancy due to greater cardiovascular disease (CVD) risk. Due to sparse data, index study was planned to assess the CVD risk factors, vascular age (VA), and hematological parameters in patients with schizophrenia and the concordance between Framingham Risk Score (FRS) for lipids and body mass index (BMI) (FRSLIPIDS and FRSBMI). Materials and Methods: Patients with schizophrenia (n = 53) were evaluated for the presence of metabolic syndrome (MS) using the modified NCEP ATP III criteria, along with their functionality, illness severity, physical activity and nutritional score, FRSLIPIDS and FRSBMI, and hematological parameters. Results: Prevalence of MS was 39.6%; in addition, 47% of patients were at risk for developing MS as they fulfilled one or two components of MS criteria and 56% of patients were obese. BMI, obesity, and RBC count were found as significant correlates for MS. CVD risk (FRS) median score (3.10) was comparable for BMI and lipid criteria along with significant correlation for FRSLIPIDS and FRSBMI (r = 0.555, P < 0.001). Conclusion: VA and 10-year CVD risk (FRS for BMI and lipid criteria) represent easier way to communicate with the patients and caregivers and also to guide for comprehensive treatment plan, appropriate nutrition, physical activity, and cardiometabolic screening.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Vascular age, cardiovascular disease risk factors, and hematological parameters in patients with Schizophrenia: An exploratory study

Vyas

Nebhinani²,

Suthar³

et al. 2022

JNRP

Self Cite

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Clinical patterns of metabolic syndrome in young, clinically stable, olanzapine-exposed patients with schizophrenia

Ma,

Zhang,

Huang

et al. 2024

Ann Gen Psychiatry

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Background Schizophrenia (SCZ) is a chronic, disabling mental illness with a high disease burden and is often comorbid with metabolic syndrome (MetS). The aim of this study was to determine the prevalence of MetS in young, clinically stable, olanzapine-exposed patients with SCZ and to explore predictive factors affecting the development and severity of MetS. Methods A total of 274 patients with SCZ who met the inclusion criteria were enrolled in this study, and their demographic data and general clinical information were collected. Concurrently, patients were assessed for psychopathology, illness severity, and antipsychotic drug–related adverse effects. Results The prevalence of MetS in the target population was 35.77%, and the MetS subtype of abdominal obesity + high triglycerides + low level of high-density lipoprotein cholesterol accounted for the majority of patients in the MetS subgroup. Binary logistic regression showed that body mass index (BMI), uric acid (UA), thyroid-stimulating hormone, and QT-c interval could significantly and positively predict the development of MetS. Multiple linear regression showed that olanzapine concentration, BMI, and UA could significantly and positively predict higher MetS scores. Conclusion This study reports the clinical patterns of MetS in young, clinically stable, olanzapine-exposed patients with SCZ and identifies the correlations influencing the development and severity of MetS. These findings could potentially be applied toward the prevention of and intervention in MetS.

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Correlates of Metabolic Syndrome in Patients with Schizophrenia: An Exploratory Study

Cited by 2 publications

References 18 publications

Vascular age, cardiovascular disease risk factors, and hematological parameters in patients with Schizophrenia: An exploratory study

Vascular age, cardiovascular disease risk factors, and hematological parameters in patients with Schizophrenia: An exploratory study

Clinical patterns of metabolic syndrome in young, clinically stable, olanzapine-exposed patients with schizophrenia

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