Aim This study is designed to explore how childbirth setting (homebirth or hospital birth) can be predicted by independent variables. Subjects and methods A cross-sectional study was conducted among 380 mothers who had planned home or hospital births within the past 6 months in Zahedan city in the southeast of Iran. Logistic regression analysis was performed on the data, which were collected by an interview-led questionnaire.Results Bivariate analysis showed that men's occupation, health insurance coverage, affordability of the hospital costs, the number of living children, a previous history of homebirth, social adherence, belief in medical care, and final score of preference for hospital, including opposition to hospital and a preference for home or opposition to home, appear as significant factors in decision making regarding the (home or hospital) childbirth setting. Conclusion Decision making about childbirth setting among women depends on their socio-economic status and perceived quality of care. Overall, suitable and available childbirth services with the women's perceived quality of care and a comprehensive understanding of how to decide about childbirth setting, which is made at a local level, can lead to more appropriate services and utilization of available childbirth services.