Correlates of recovery of social functioning in types I and II bipolar disorder patients

Abstract

Since bipolar disorder (BPD) patients are often functionally impaired, and factors associated with recovery from disability are largely unknown, we investigated demographic, clinical, and neurocognitive correlates of current social functional recovery in 65 stable participants diagnosed with DSM-IV type I (n=42) or II (n=23) BPD. Regaining highest previous levels of social functioning was rated with the Interpersonal Relationships Questionnaire. We also considered neuropsychological test findings as well as demographic and clinical information including mania and depression symptom-ratings. We examined factors associated with social recovery status using univariate analyses and then multiple logistic regression modeling. Of all subjects, 30 (46%) achieved current social functional recovery and 35 (54%) did not. Younger age (p=0.005) and lesser current depressive symptoms (p=0.02) were associated with social functional recovery, even after controlling for time since the last major mood episode, diagnostic type (II vs. I), co-morbid psychiatric illness, and executive functioning status. The findings are consistent with deleterious effects of even residual depressive symptoms in BPD patients.

Aripiprazole Adjunct Treatment in Bipolar I or II Disorder, Depressed State

“…Using the SDS, we showed recovery in 50% of patients at 6 months and 100% at 1 year, which was maintained at 2 years. Many of the studies conducted in the past 5 years have not demonstrated such a high degree of functional recovery, with rates of approximately 35% to 65% by years (Conus et al, 2006;Dickerson et al, 2010;Kauer-Sant'Anna et al, 2009;Wingo et al, 2010). Our patients were more severely affected than BPD patients previously reported in the literature (Gutierrez-Rojas et al, 2011) but made better long-term functional recovery, making the effect all the more impressive.…”

Longitudinal Associations Between Interpersonal Relationship Functioning and Mood Episode Severity in Youth With Bipolar Disorder

“…We expected that a more severe course of illness would indicate poorer interpersonal relationship functioning, as has been found in previous research (Johnson et al, 2003, Sullivan and Miklowitz, 2010, Uebelacker et al, 2006, Wingo et al, 2010). Next, we examined whether changes in mood episode severity (depression and mania) predicted changes in interpersonal functioning, or vice versa, over time (comparisons of the same participant at different time points, or within-person analyses).…”

“…In studies of BP adolescents and adults, interpersonal difficulties have been associated with greater symptom severity and higher rates of relapse, when measured at the same time point (i.e., cross-sectionally) (Johnson et al, 2003, Sullivan and Miklowitz, 2010, Uebelacker et al, 2006, Wingo et al, 2010). Cross-sectional studies, however, do not elucidate the associations between mood and interpersonal functioning over time.…”

Distinct facial processing in schizophrenia and schizoaffective disorders

“…In addition to their positive psychotic symptoms, this group of patients also experienced various mood problems. Patients with mood disturbances tend to be impaired in their social interactions (Schoeyen et al 2011; Wingo et al 2010). Since affective and non- affective face information plays a major role in social interactions (Haxby et al 2002), it would be expected that face perception and mood disturbances would be associated with each other as well, and thus that patients with schizoaffective disorder would be more deficient in face perception than schizophrenia patients.…”