Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan

Wesselink, Amelia K.; Fruh, Victoria; Hauser, Russ; Weuve, Jennifer; Taylor, Kyla W.; Orta, Olivia R.; Henn, Birgit Claus; Bethea, Traci N.; McClean, Michael D.; Williams, Paige L.; Calafat, Antònia M.; Baird, Donna D.; Wise, Lauren A.

doi:10.1038/s41370-020-00270-9

Cited by 19 publications

(16 citation statements)

References 58 publications

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“…These race and ethnicity trends are consistent with the results of previous studies. 6,7,11 Though we did not collect data on specific brands or product constituents, prior work has shown that the products marketed to Black/African American women tend to have higher levels of potentially harmful chemicals, 5,6,14,29 further augmenting the exposure burden for this demographic group. 7 Women were fairly consistent in their reported use of both products, and reliability improved further when more general classifications of ever versus never use were compared.…”

Section: Discussionmentioning

confidence: 99%

Douching and Genital Talc Use: Patterns of Use and Reliability of Self-reported Exposure

et al. 2023

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Background: Feminine hygiene products contain chemicals that may be harmful to human health. Observational studies of the longterm health effects of such products largely rely on self-reported, recalled exposure. We sought to capture patterns of use over the life course and evaluate the reliability of self-reported data. Methods: We collected retrospective data on douching and genital talc use in the US-based Sister Study at two-time points and evaluated the consistency of reporting. At enrollment (2003)(2004)(2005)(2006)(2007)(2008)(2009), participants were asked to report use in the last year and during ages 10-13. On a follow-up questionnaire (2017-2019), participants were asked about their use of douche or genital talc over their lifetimes. Results: Among 36,202 women who completed both questionnaires, 14% initially reported ever douching and 27% initially reported ever using genital talc. On the follow-up questionnaire, 51% of participants reported ever douching and 32% reported ever using genital talc. Comparisons across the two questionnaires for use in the year before enrollment showed good consistency, with 90% providing the same responses about douching and 87% providing the same responses about genital talc use. Reliability did not vary by cancer status, race and ethnicity, attained education, or age, though there was some evidence of recall bias for genital talc use among ovarian cancer survivors. Conclusions: Classification of ever use of feminine hygiene products may be recalled with good consistency, but agreement was lower for specific time periods and trends may vary by subgroup. These potential differences warrant careful consideration in future studies.

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Section: Discussionmentioning

confidence: 99%

Douching and Genital Talc Use: Patterns of Use and Reliability of Self-reported Exposure

et al. 2023

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“…We considered personal care products as potential correlates of biomarker EDC concentrations based on our prior analyses in the SELF cohort. − Product use correlates were assessed at baseline using questionnaires and included reported use (yes or no) of vaginal deodorant, vaginal powder, and cosmetics (makeup, lotion before bed, perfume, and nail polish) in the past 24 h. We also assessed the frequency of sunscreen use while outside, which was reported as never/hardly ever, sometimes, often, or always/nearly always. We dichotomized sunscreen use (never/hardly ever vs any reported use) given small sample sizes in several strata.…”

Section: Methodsmentioning

confidence: 99%

“…Details of sample collection and quality control have been described previously. 23,24 Briefly, we collected spot urine samples from participants during the baseline visit at Henry Ford Health, which were stored at −80 °C until shipped on dry ice overnight to the NIEHS biorepository, where they were stored at −80 °C. Urine samples were then shipped overnight from the NIEHS to the CDC on dry ice for quantification of EDCs using online solid phase extraction coupled with highperformance liquid chromatography isotope dilution tandem mass spectrometry, as described previously.…”

Section: Study Populationmentioning

confidence: 99%

Personal Care Products, Socioeconomic Status, and Endocrine-Disrupting Chemical Mixtures in Black Women

Schildroth,

Bethea,

Wesselink

et al. 2024

Environ. Sci. Technol.

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Personal care products (PCPs) are sources of exposure to endocrine-disrupting chemicals (EDCs) among women, and socioeconomic status (SES) may influence these exposures. Black women have inequitable exposure to EDCs from PCP use, but no study has investigated how exposure to EDCs through PCPs may vary by SES, independent of race. Using data from the Study of Environment, Lifestyle, and Fibroids, a cohort of reproductive-aged Black women (n = 751), we quantified associations between PCPs and urinary biomarker concentrations of EDC mixtures (i.e., phthalates, phenols, parabens) within SES groups, defined using k-modes clustering based on education, income, marital status, and employment. Information about PCP use and SES was collected through questionnaires and interviews. We used principal component analysis to characterize the EDC mixture profiles. Stratified linear regression models were fit to assess associations between PCP use and EDC mixture profiles, quantified as mean differences in PC scores, by SES group. Associations between PCP use and EDC mixture profiles varied by SES group; e.g., vaginal powder use was associated with a mixture of phenols among lower SES women, whereas this association was null for higher SES women. Findings suggest that SES influences PCP EDC exposure in Black women, which has implications for public health interventions.

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“…Because both PCA and k- means clustering are sensitive to outlier values, , we performed a sensitivity analysis that identified and removed outliers using Rosner’s generalized extreme Studentized deviate test to determine if outlier biomarker concentrations affected overall correlate associations. Finally, we re-ran our regression models with a reduced number of correlates, as done previously in SELF, to ensure that our main findings were not biased by conditioning on mediators or colliders. We selected correlates for these models based on previously identified correlates of exposure in the SELF cohort. − …”

Section: Methodsmentioning

confidence: 99%

Correlates of Persistent Endocrine-Disrupting Chemical Mixtures among Reproductive-Aged Black Women

Schildroth

Wise

Wesselink

et al. 2021

Environ. Sci. Technol.

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Black women are exposed to multiple endocrinedisrupting chemicals (EDCs), but few studies have examined their profiles of exposure to EDC mixtures. We identified biomarker profiles and correlates of exposure to EDC mixtures in a crosssectional analysis of data from a prospective cohort study of 749 Black women aged 23−35 years. We quantified plasma concentrations of polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), organochlorine pesticides (OCPs), and per-and polyfluoroalkyl substances (PFAS) in nonfasting samples collected at baseline. Demographic, behavioral, dietary, and reproductive covariates were also collected at baseline. We used kmeans clustering and principal component analysis (PCA) to describe concentration profiles of EDC mixtures (17 PCBs, 6 PBDEs, 4 OCPs, 6 PFAS), followed by multinomial logistic and multivariable linear regression to estimate mean differences in PCA scores (β) and odds ratios (ORs) of cluster membership with their respective 95% confidence intervals (CIs). Older age (per 1 year increase: β = 0.47, CI = 0.39, 0.54; OR = 1.27, CI = 1.20, 1.35), lower body mass index (per 1 kg/m 2 increase: β = −0.14, CI = −0.17, −0.12; OR = 0.91, CI = 0.89, 0.94), and current smoking (≥10 cigarettes/day vs never smokers: β = 1.37, CI = 0.20, 2.55; OR = 2.63, CI = 1.07, 6.50) were associated with profiles characterized by higher concentrations of all EDCs. Other behaviors and traits, including dietary factors and years since last birth, were also associated with EDC mixtures.

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Correlates of urinary concentrations of phthalate and phthalate alternative metabolites among reproductive-aged Black women from Detroit, Michigan

Cited by 19 publications

References 58 publications

Douching and Genital Talc Use: Patterns of Use and Reliability of Self-reported Exposure

Douching and Genital Talc Use: Patterns of Use and Reliability of Self-reported Exposure

Personal Care Products, Socioeconomic Status, and Endocrine-Disrupting Chemical Mixtures in Black Women

Correlates of Persistent Endocrine-Disrupting Chemical Mixtures among Reproductive-Aged Black Women

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