Correlating causative factors in cleft lip and palate patients: An epidemiological study

Desai, Bhagyashree B; Patel, Dolly; Sinha, Surina V; Jain, Mahesh; Patel, Roopal; Bhanat, Sheron

doi:10.4103/jclpca.jclpca_12_18

Cited by 8 publications

(3 citation statements)

References 13 publications

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“…A contrasting view has been promulgated by Khajanchi et al who asserted in their work that occurrence of CL was the most common cleft abnormality followed by CL/P [22]. Environmental factors have been associated with increased risk of CL/P including: consanguinity, smoking, alcohol ingestion, use of anticonvulsants during pregnancy as well as insufficient folic acid intake in the pregestational period and first trimester of pregnancy [23]. Mekelle city is fast evolving as the commercial hub of the northern part of Ethiopia with high rate of smoking, alcohol use and other forms of social indulgences.…”

Section: Discussionmentioning

confidence: 99%

Anatomical patterns of cleft lip and palate deformities among neonates in Mekelle, Tigray, Ethiopia; implication of environmental impact

2019

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Background Cleft lip and palate deformities are considered one of the most common birth defects of the head and neck that pose significant medical, psychosocial and financial burdens on the affected individuals and families, especially in low income communities. The etiology and pathogenesis of cleft lip and palate is complex and is known to involve genetic and/or environmental factors. Objective To assess the patterns of anatomical cleft lip and palate deformities among neonates in Mekelle and Ayder Comprehensive Specialized hospitals, Tigray, Northern Ethiopia. Methods A hospital-based retrospective study was conducted from May 2017 to June 2017 at Mekelle and Ayder Comprehensive Specialized hospitals, both in Mekelle city. Data was collected from all medical charts of neonates registered from 2011 to 2016 and analyzed using SPSS version 21.0 and OpenEpi software. Results were presented using tables and graphs; Chi-square test was used to look for an association between variables, odds ratio to determine the strength of association of selected variables using multinomial logistic regression model, while Fisher Exact (Clopper-Pearson) was used to compare yearly prevalence. Results Of 37,152 neonatal charts analyzed, 119 (0.32%) cases were identified as having cleft deformities. 38.7, 17.6, and 43.7% of this figure had cleft lips, cleft palates and both cleft lip and palate respectively. 46 (38.7%) neonates had lateral patterns of cleft lip deformities with 56.5% located unilaterally on the right and 43.5% unilaterally on the left. Of 52 (43.7%) neonates with cleft lip and palate deformities, 40.4% were located bilaterally while 38.5 and 21.2% were located unilaterally on the left and right, respectively. Associated malformations were: cardiac (3.4%), central nervous system (1.7%) and limb deformities (5.9%). The overall prevalence of cleft deformities was found to be 3.11 per 1000 live births. Conclusion The study showed a higher prevalence of cleft deformities than that reported in Addis Ababa and some other African countries. A higher occurrence of left unilateral pattern of cleft lip and palate was observed whereas a higher right unilateral pattern of cleft lip was identified. The higher prevalence of cleft lip and palate recorded in this region of Ethiopia may reflect an environmental impact.

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Section: Discussionmentioning

confidence: 99%

Anatomical patterns of cleft lip and palate deformities among neonates in Mekelle, Tigray, Ethiopia; implication of environmental impact

2019

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“…(2) (3) (4) Its etiology is complex and both genetic and environmental factors such as vitamin deficiency (folic acid, vitamin B6 and B12), smoking (alteration of metabolic pathways by aromatic and heterocyclic amines), alcohol consumption (inhibition of retinoic acid synthesis), drug use (vasoactive, antiepileptic, acne, psoriasis, cancer) and exposure to chemicals (cleaning products, cosmetics) are directly associated with a higher incidence of newborns with this anomaly (5) (6) (7). (5) (6) (7) (8) (9) (10) The condition is manifested by characteristic symptoms affecting respiratory, swallowing, articulatory and auditory mechanisms. (11) In addition, infants with FLAP are at increased risk for abnormalities such as: supernumerary teeth, dental agenesis, dental deformities (especially in alveolar fissures); caries and periodontal disease are also more common in children with this anomaly.…”

Section: Problem Statement and Justificationmentioning

confidence: 99%

Prevalence of cleft lip-alveolo-palate in pediatric patients at the Vicente Corral Moscoso hospital, period 2016-2020

Méndez¹,

Jaramillo²,

Calle³

2023

World J. Adv. Res. Rev.

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Cleft lip-alveolar-palatal fissures (FLAP) are one of the most frequent congenital malformations nationwide. Its etiology is complex and both genetic and environmental factors are directly associated with a higher number of births with this anomaly. The aim of this work is to determine the prevalence of FLAP in pediatric patients of the Vicente Corral Moscoso Hospital in the city of Cuenca in the period 2016-2020. For this purpose, the collection of medical records of patients with FLAP under 17 years of age between the period of 2016 to 2020 was carried out. The data obtained from the 582 records, were subjected to statistical analysis using the computer program IBM SPSS Statistics version 20; gender, age range, type and location of the fissure were analyzed. The results showed that 69.6% of the study sample belonged to the male gender and 30.4% to the female gender. The highest prevalence in age corresponds to the year with a percentage of 24.7%. According to its location, the most common type of cleft corresponds to the mixed cleft with 43.13%; and finally, according to the type, cleft of the hard palate and soft palate with unilateral cleft lip was the one with the most reported cases with a percentage corresponding to 24.2%.

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“…Despite the number of identifiable contributing factors, etiology of most clefts is multifactorial, complex, and remains to be completely delineated. (Desai et al, 2019).Multiple environmental factors have also been linked with CLP. Risk factors include smoking, pregestational and gestational diabetes, alcohol abuse, and certain anticonvulsants.…”

Section: Introductionmentioning

confidence: 99%

Impact Of An Educational Program Regarding Cleft Palate On Mothers Awareness And Their Infants Feeding Pattern

Ragab

Abed-El-kreem

Mohamed

et al. 2023

Minia Scientific Nursing Journal

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Background: Cleft lip and palate (CLP) is one of the most common congenital craniofacial abnormalities in the world, genetic and environmental factors play a significant role in its etiology. Pre-operative nursing education to mothers of cleft palate infants is directed toward improving infants feeding .Aim of the study: The aim of the current study was to evaluate the impact of an educational program regarding cleft palate on mother's awareness and their infants feeding pattern. Research design: Quasi-experimental research design (pre-posttest) was used in the current study. Setting: The current study was conducted at out-patient surgery unit at Minia university hospital for obstetric and pediatric, which located in Minia city. Subjects: A purposeful sample of 60 mothers of children with cleft palate was participated in the study: 30 for study group and 30 for control group. Research tools: Tool (I): A structured interview questionnaire: it covered sociodemographic data of mothers and data of infants and mothers' knowledge about cleft palate; Tool (II): Feeding pattern mothers' practice assessment checklist; Tool (III): Observational checklist about bottle feeding preparation; Tool (IV): Egyptian Growth Curve Chart (EGCC). Results: It was found that there were highly statistically significant differences between the study and control groups of mothers' knowledge regarding cleft palate in pre, post and follow up-test P-value at 0.000001. As well as almost of the mothers in the posttest in the study group had appropriate level of practice in regarding feeding infants with cleft palate. The results of the current study showed that there is a positive correlation between the total score of mothers' knowledge and their practices in pre and post-test, and follow up test Conclusion: The study concluded that the preoperative instructions for mothers of cleft palate infants were effective in the improvement of mothers knowledge, practices and infant weight and feeding pattern .Recommendation: The study recommended that developing continuous training session to pediatric surgical nurses and educational sessions for mothers about cleft palate and feeding infants with cleft palate would improve mothers' knowledge, practices and their infants feeding pattern.

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Correlating causative factors in cleft lip and palate patients: An epidemiological study

Cited by 8 publications

References 13 publications

Anatomical patterns of cleft lip and palate deformities among neonates in Mekelle, Tigray, Ethiopia; implication of environmental impact

Anatomical patterns of cleft lip and palate deformities among neonates in Mekelle, Tigray, Ethiopia; implication of environmental impact

Prevalence of cleft lip-alveolo-palate in pediatric patients at the Vicente Corral Moscoso hospital, period 2016-2020

Impact Of An Educational Program Regarding Cleft Palate On Mothers Awareness And Their Infants Feeding Pattern

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