Correlating diameter, mechanical and structural properties of poly(l-lactide) fibres from needleless electrospinning

Morel, Alexandre; Domaschke, Sebastian; Kumaran, Varun Urundolil; Alexeev, Dmitriy; Sadeghpour, Amin; Ramakrishna, Shivaprakash N.; Ferguson, Stephen J.; Rossi, René M.; Mazza, Edoardo; Ehret, Alexander E.; Fortunato, Giuseppino

doi:10.1016/j.actbio.2018.09.055

Cited by 50 publications

(32 citation statements)

References 54 publications

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“…A direct linear relationship between modulus and crystalline fraction has been observed experimentally in ES single fibers of similar semicrystalline polymers 56 as well as theoretically 57 . The membranes made up of medium diameter fibers showed an anomalous measurement at time point 180 days that was inconsistent with possible material behavior as well as with observations found in literature and membranes with fibers of other diameters.…”

Section: Discussionsupporting

confidence: 66%

“…This finding implies surface area controlled process, as when the easily accessible surface region is degraded, the bond cleavage that relies on hydration, proceeds at much slower pace in the bulk. Hence, thick fibers reached the plateau degradation state much quicker than thin fibers that have much more surface relative to bulk.A direct linear relationship between modulus and crystalline fraction has been observed experimentally in ES single fibers of similar semicrystalline polymers56 as well as theoretically 57. The membranes made up of medium diameter fibers showed an anomalous measurement at time point 180 days that was inconsistent with possible material behavior as well as with observations found in literature and membranes with fibers of other diameters.…”

supporting

confidence: 66%

“…58 The mismatch between the expected change in material properties and observations on ES networks arise from the complex fiber-fiber interactions which play a key role during fiber reorientation under stress. 56,59 In particular, inter-fiber adhesion, which plays one of the key roles, 60 ± 13.1 SD. 71 Others recorded even lower strains at failure of 13% to 25%.…”

Section: Evolution Of Mechanical Propertiesmentioning

confidence: 99%

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Electrospun biodegradable poly(ε‐caprolactone) membranes for annulus fibrosus repair: Long‐term material stability and mechanical competence

et al. 2020

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Background: Electrospun (ES) poly(ϵ-caprolactone) (PCL) is widely used to provide critical mechanical support in tissue engineering and regenerative medicine applications. Therefore, there is a clear need for understanding the change in the mechanical response of the membranes as the material degrades in physiological conditions. Study Design: ES membranes with fiber diameters from 1.6 to 6.7 μm were exposed to in vitro conditions at 37 C in Dulbecco's modified Eagle's medium (DMEM) or dry for up to 6 months. Methods: During this period, the mechanical properties were assessed using cyclic mechanical loading, and material properties such as crystallinity and ester bond degradation were measured. Results: No significant difference was found for any parameters between samples kept dry and in DMEM. The increase in crystallinity was linear with time, while the ester bond degradation showed an inverse logarithmic correlation with time. All samples showed an increase in modulus with exposure time for the first loading cycle. Modulus changes for the consecutive loading cycles showed a nonlinear relationship to the exposure time that depended on membrane type and maximum strain. In addition, the recovered elastic range showed an expected increase with the maximum strain reached. The mechanical response of ES membranes was compared to experimental tensile properties of the human annulus fibrosus tissue and an in silico model of the intervertebral disk. The modulus of the tested membranes was at the lower range of the values found in literature, while the elastically recoverable strain after preconditioning for all membrane types lies within the desired strain range for this application. Conclusion: The long-term assessment under application-specific conditions allowed to establish the mechanical competence of the electrospun PCL membranes. It can be concluded that with the use of appropriate fixation, the membranes can be used to create a seal on the damaged AF.

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Section: Discussionsupporting

confidence: 66%

supporting

confidence: 66%

Section: Evolution Of Mechanical Propertiesmentioning

confidence: 99%

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Electrospun biodegradable poly(ε‐caprolactone) membranes for annulus fibrosus repair: Long‐term material stability and mechanical competence

et al. 2020

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“…[16][17][18] The combined role of polymer chemical structure and nanofiber alignment shows a significant effect in promoting interactions with cells, such as controlling the phenotype and morphology of osteoblasts 16 and skeletal myoblasts. 14,15,19 In vascular graft applications, topography driven from the size distribution of nanofibers influences the platelets adhesion on membranes and the blood compatibility. 20 It is well understood that the folding of the polymeric chains into nanofibers and their morphology is highly dependent not only on the conductivity of the electrospinning solution, the spinning parameters, 21 and the post-treatment of the nanofiber membranes, 22 but also on the polymer type and environmental conditions.…”

Section: Introductionmentioning

confidence: 99%

Structural insights into semicrystalline states of electrospun nanofibers: a multiscale analytical approach

et al. 2019

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“…This size effect on the elastic modulus of nanofibers has been reported in numerous studies. It has been proved that orientation in crystalline and amorphous domains are higher in thinner fibers, resulting in an increase of elastic modulus [51][52][53]. Since tapping mode AFM measurements showed that there is a reduction of about 30% in diameter of nanofibers from the annealing process (from 210 ± 88 nm for the pristine fibers to 160 ± 44 nm for the annealed samples), for a meaningful comparison, we should compare the elastic modulus of annealed nanofibers to that of as-spun nanofibers with a relatively higher diameter.…”

Section: Comparison Of the Elastic Modulus Between Pristine And Anneamentioning

confidence: 99%

On the Nanoscale Mapping of the Mechanical and Piezoelectric Properties of Poly (L-Lactic Acid) Electrospun Nanofibers

et al. 2020

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The effect of the post-annealing process on different properties of poly (L-lactic acid) (PLLA) nanofibers has been investigated in view of their use in energy-harvesting devices. Polymeric PLLA nanofibers were prepared by using electrospinning and then were thermally treated above their glass transition. A detailed comparison between as-spun (amorphous) and annealed (semi-crystalline) samples was performed in terms of the crystallinity, morphology and mechanical as well as piezoelectric properties using a multi-technique approach combining DSC, XRD, FTIR, and AFM measurements. A significant increase in the crystallinity of PLLA nanofibers has been observed after the post-annealing process, together with a major improvement of the mechanical and piezoelectric properties.

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Correlating diameter, mechanical and structural properties of poly(l-lactide) fibres from needleless electrospinning

Cited by 50 publications

References 54 publications

Electrospun biodegradable poly(ε‐caprolactone) membranes for annulus fibrosus repair: Long‐term material stability and mechanical competence

Electrospun biodegradable poly(ε‐caprolactone) membranes for annulus fibrosus repair: Long‐term material stability and mechanical competence

Structural insights into semicrystalline states of electrospun nanofibers: a multiscale analytical approach

On the Nanoscale Mapping of the Mechanical and Piezoelectric Properties of Poly (L-Lactic Acid) Electrospun Nanofibers

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