Correlating reported fever in young infants with subsequent temperature patterns and rate of serious bacterial infections

Bonadio, William A.; Hegenbarth, Mary; Zachariason, Michael

doi:10.1097/00006454-199003000-00002

Cited by 51 publications

(24 citation statements)

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“…However, prior research has demonstrated the validity of parental reports of febrile illnesses when a thermometer reading is provided, which occurred in the majority of family reports of fever (Bonadio, Hegenbarth et al 1990). In addition, we did not ask the parents to obtain temperature readings from their children when an illness was not suspected which may have decreased the sensitivity of parent report, especially from less attentive parents.…”

Section: Discussionmentioning

confidence: 99%

The associations between psychosocial stress and the frequency of illness, and innate and adaptive immune function in children

Caserta

O’Connor

Wyman

et al. 2008

Brain, Behavior, and Immunity

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Objective-Family processes have a substantial impact on children's social and emotional wellbeing, but little is known about the effects of family stress on children's physical health. To begin to identify potential links between family stress and health in children, we examined associations between specific aspects of family psychosocial stress and the frequency of illnesses in children, measures of innate and adaptive immune function, and human herpesvirus 6 (HHV-6) reactivation.Study Design-Prospective study of 169 ambulatory school-age children and parents. Parents completed multiple assessments of stress at 7 sequential six-month visits and maintained weekly illness diaries for their children over three years using a thermometer to record fever. Children had blood obtained for HHV-6 and immune function studies at each visit including natural killer (NK) cell function and the percentage of CD4 and CD8 cells associated with immune control of cytomegalovirus (CMV).Results-Parental psychiatric symptoms were associated with a higher frequency of illnesses: for each 1 unit increase in symptom score children had an increased 1-year rate of total illnesses of 40% (rate ratio, 1.40; 95% CI, 1.06-1.85) and febrile illnesses of 77% (rate ratio, 1.77, 95% CI, 1.00-3.13). Parental psychiatric symptom scores were also associated with enhanced NK cell function (estimate, 0.15; 95% CI, 0.05-0.26) and increased percentages of CD8+CD28-CD57+ cells in the Corresponding author: Mary T. Caserta, M.D., Associate Professor of Pediatrics, Box 690, 601 Elmwood Ave., Rochester, NY 14642, Tel: (585) Fax: (585) 273-1104, e-mail: mary_caserta@urmc.rochester.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. CI,). HHV-6 reactivation was not detected. NIH Public AccessConclusions-There is an association between specific psychosocial stress exposure and rates of illness and immune function in normally developing children.Psychosocial stress adversely affects physical health. This connection has been demonstrated most convincingly in studies with diverse populations of adults, including an association between stress and an increased risk of mortality (Schulz and Beach 1999;Ickovics, Hamburger et al. 2001). Psychosocial stress also has reproducible effects on the human immune system. Chronic stress experiences of adults are associated with decreases in natural killer (NK) cell cytotoxicity, lower antibody titers to influenza vaccine, diminished delayed type hypersensitivity responses, and decreased lymphocyte proliferation (Segerstrom and Miller 2004;Glaser and Kiecolt-Glaser 2005). A...

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Section: Discussionmentioning

confidence: 99%

The associations between psychosocial stress and the frequency of illness, and innate and adaptive immune function in children

Caserta

O’Connor

Wyman

et al. 2008

Brain, Behavior, and Immunity

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“…Conversely, invasive life-threatening and other infections, such as acute otitis media, can occur in the absence of fever (e.g., up to 45% of children with acute otitis media do not present with fever) or even with hypothermia [26][27][28][29][30][31]. Thus, the presence of fever is only one of many clinical observations that can be used to assess the nature and severity of an illness; it must always be taken in context with a thorough clinical evaluation integrating historical data, physical findings, behavior, age (special caution needs to be given to different approaches for different age groups) [26], and responsiveness [2,26,29,32].…”

Section: Misconceptions About Fevermentioning

confidence: 99%

Fever after Immunization: Current Concepts and Improved Future Scientific Understanding

Kohl¹,

Marcy²,

Blum³

et al. 2004

Clinical Infectious Diseases

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Fever is a common clinical complaint in adults and children with a variety of infectious illnesses, as well as a frequently reported adverse event following immunization. Although the level of measured temperature indicative of a "fever" was first defined in 1868, it remains unclear what role fever has as a physiologic reaction to invading substances, how best to measure body temperature and compare measurements from different body sites, and, consequently, how to interpret fever data derived from vaccine safety trials or immunization safety surveillance. However, even with many aspects of the societal, medical, economic, and epidemiologic meanings of fever as an adverse event following immunization (AEFI) still elusive, it is a generally benign--albeit common--clinical sign. By standardizing the definition and means of assessment of fever in vaccine safety studies, thereby permitting comparability of data, we hope to arrive at an improved understanding of its importance as an AEFI.

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“…[2][3][4][5][6] In particular, the clinical implications of parental fever beliefs have not received much attention, and little is known about the fever beliefs and practices of Latino families. [2][3][4][5][6] In particular, the clinical implications of parental fever beliefs have not received much attention, and little is known about the fever beliefs and practices of Latino families.…”

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confidence: 99%

Parents' Beliefs and Practices Regarding Childhood Fever

Taveras¹,

Durousseau²,

Flores³

2004

Pediatric Emergency Care

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Correlating reported fever in young infants with subsequent temperature patterns and rate of serious bacterial infections

Cited by 51 publications

References 0 publications

The associations between psychosocial stress and the frequency of illness, and innate and adaptive immune function in children

The associations between psychosocial stress and the frequency of illness, and innate and adaptive immune function in children

Fever after Immunization: Current Concepts and Improved Future Scientific Understanding

Parents' Beliefs and Practices Regarding Childhood Fever

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