Correlation among isolated teratozoospermia, sperm DNA fragmentation and markers of systemic inflammation in primary infertile men

Candela, Luigi; Boeri, Luca; Capogrosso, Paolo; Cazzaniga, Walter; Pozzi, Edoardo; Belladelli, Federico; Ravizzoli, Andrea; Ventimiglia, Eugenio; Viganò, Paola; Alfano, Massimo; Abbate, Carlo; Cornelius, Julian; Mattei, Agostino; Montorsi, Francesco

doi:10.1371/journal.pone.0251608

Cited by 21 publications

(13 citation statements)

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“…Finally, although an association between impaired renal function and semen parameters was not observed, we did not examine alterations in the sperm quality profile that could be even more sensitive to alterations in the state of overall men's health, such as an increase in the percentage of sperm DNA fragmentation. [42][43][44] In addition, we included a very selected group of infertile men, that is, those with availability of eGFR evaluation in a tertiary referral center; therefore, the study of association of putative risk factors such as impaired kidney function with impaired semen analysis might be biased by information and selection bias. Further studies with larger cohorts are certainly needed.…”

Section: Discussionmentioning

confidence: 99%

“…Third, for the definition of CKD, we used the threshold set by the KDIGO guidelines (i.e., defining kidney function impairment as eGFR < 90 mL/min per 1.73 m 2 and CKD as eGFR < 60 mL/min per 1.73 m 2 ); however, evidence exists that the threshold for CKD should be set at higher eGFR levels for younger individuals, 41 thus potentially increasing the proportion of men with initial kidney function impairment among young men with primary infertility. Finally, although an association between impaired renal function and semen parameters was not observed, we did not examine alterations in the sperm quality profile that could be even more sensitive to alterations in the state of overall men's health, such as an increase in the percentage of sperm DNA fragmentation 42–44 . In addition, we included a very selected group of infertile men, that is, those with availability of eGFR evaluation in a tertiary referral center; therefore, the study of association of putative risk factors such as impaired kidney function with impaired semen analysis might be biased by information and selection bias.…”

Section: Discussionmentioning

confidence: 99%

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Kidney function impairment in men with primary infertility: A case–control analysis

et al. 2023

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BackgroundInfertile men have a worse overall health status than their fertile counterparts.ObjectiveWe aimed to (1) compare kidney function in men presenting for primary couple's infertility with that of fertile men and (2) assess kidney function impairment toward sperm quality in infertile men.Materials and methodsIn this case–control study, 387 consecutive white‐European infertile men were matched by age with 134 same‐ethnicity fertile men. Complete clinical and laboratory data were available for each patient. The Chronic Kidney Disease Epidemiology Collaboration function was used for estimated glomerular filtration rate calculation. Kidney functional impairment was defined as an estimated glomerular filtration rate <90 mL/min per 1.73 m2, according to the Kidney Disease Improving Global Outcomes criteria. Multivariable logistic regression analysis was used to (1) assess the association between kidney function impairment and infertility status and (2) investigate the association between kidney function and semen analysis abnormalities in infertile men.ResultsAfter matching, 34 (8.8%) infertile men depicted at least a mild unknown impairment of kidney function compared to only four (3%) fertile men, with four (3%) of the infertile presenting with an overt kidney function impairment (estimated glomerular filtration rate <60 mL/min per 1.73 m2). There were no differences in terms of age, body mass index and rate of comorbidities between the two groups (all p > 0.05). After adjusting for major confounders, infertility status was associated with a higher risk of reduced estimated glomerular filtration rate (odds ratio 3.20; 95% confidence interval 1.21–5.2; p = 0.002). Conversely, estimated glomerular filtration rate was not associated with sperm abnormalities in infertile men.ConclusionsMild kidney function impairment was found in 9% of asymptomatic and unaware men presenting for primary couple's infertility investigation. This novel finding corroborates growing data on a significant association of male infertility with a poorer overall male health status and the need for tailored preventive strategies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Kidney function impairment in men with primary infertility: A case–control analysis

et al. 2023

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“…Furthermore, it has been reported that the prevalence of isolated teratozoospermia may be more prevalent in fertile controls compared to infertile men. 16 We questioned eight heterozygote females from our study (F1:IV-1, IV-3, and V-5; F2:II- Kaposi sarcoma is caused by Kaposi sarcoma herpesvirus/human herpesvirus 8 (KSHV/HHV8) infection. Most people may have KSHV/ HHV8 in their system and they do not develop Kaposi sarcoma unless their immune system is impaired.…”

Section: Discussionmentioning

confidence: 99%

Expanding the spectrum of syndromic PPP2R3C‐related XY gonadal dysgenesis to XX gonadal dysgenesis

et al. 2021

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Homozygous variants in PPP2R3C have been reported to cause a syndromic 46,XY complete gonadal dysgenesis phenotype with extragonadal manifestations (GDRM, MIM# 618419) in patients from four unrelated families, whereas heterozygous variants have been linked to reduced fertility with teratozoospermia (SPGF36, MIM# 618420) in male carriers. We present eight patients from four unrelated families of Turkish and Indian descent with three different germline homozygous PPP2R3C variants including a novel in-frame duplication (c.639_647dupTTTCTACTC, p. Ser216_Tyr218dup). All patients exhibit recognizable facial dysmorphisms allowing gestalt diagnosis. In two 46,XX patients with hypergonadotropic hypogonadism and nonvisualized gonads, primary amenorrhea along with absence of secondary sexual characteristics and/or unique facial gestalt led to the diagnosis. 46,XY affected individuals displayed a spectrum of external genital phenotypes from ambiguous genitalia to complete female. We expand the spectrum of syndromic PPP2R3C-related XY gonadal dysgenesis to both XY and XX gonadal dysgenesis. Our findings supported neither ocular nor muscular involvement as major criteria of the syndrome. We also did not encounter infertility problems in the carriers. Since both XX and XY individuals were affected, we hypothesize that PPP2R3C is essential in the early signaling cascades controlling sex determination in humans.

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“…Semen analyses were based on 2010 WHO reference criteria 14 : oligozoospermia was defined as <15 million spermatozoa per ml; asthenozoospermia as <32% progressive motility; and teratozoospermia <4% of typical forms 19 . Sperm DNA fragmentation (SDF) index was measured by sperm chromatin structure assay 20 …”

Section: Methodsmentioning

confidence: 99%

High serum alpha‐fetoprotein levels in primary infertile men

et al. 2022

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Background Alfa‐fetoprotein (AFP) is a serum glycoprotein highly produced during fetal development. While AFP synthesis drops dramatically after birth, AFP production only persists or returns under specific pathological condition. Objective We sought to investigate the rate of and the potential meaning of high AFP serum levels in men seeking first medical attention for couple's primary infertility. Materials and methods Socio‐demographic and clinical data from 1803 non‐Finnish, White‐European primary infertile men were retrospectively analysed. AFP was routinely measured in each patient (high AFP was defined as >7 ng/ml). Men with history of liver diseases, testicular cancer, or other known causes of increased AFP levels were excluded from the final analysis. Semen analyses were based on the 2010 World Health Organization reference criteria. Descriptive statistics and logistic regression models tested the association between serum AFP and clinical variables. Possible nonlinear relationships were graphically explored with locally estimated scatterplot smoothing method. Results Overall, high serum AFP level was found in 29 (1.7%) patients. Normal versus high AFP levels patients were comparable in terms of body mass index (BMI), Charlson Comorbidity Index, waist circumference, smoking habits, history of cryptorchidism, testicular volume, and serum hormones (i.e., follicle‐stimulating hormone, luteinizing hormone, and total testosterone). Conversely, men with higher AFP levels were older (p = 0.02), had lower sperm concentration (p = 0.003), and were more frequently oligozoospermic and azoospermic (all p ≤ 0.03). At multivariate analysis, high AFP levels were independently associated with oligozoospermia (OR 3.79; p = 0.033) and azoospermia (OR 3.29; p = 0.006). Likewise, if AFP levels increase, patients were found to be older, with higher BMI and to have more comorbidities (all p < 0.05). Discussion Unexplained high AFP levels account for almost 2% of cases in primary infertile patients without a previous history of associated disorders. Higher serum AFP levels are linked with aberrant sperm counts, older age, obesity, and a greater amount of comorbid conditions. Conclusion Despite the need for additional validation, these data suggest that serum AFP measurement might have a multifaceted role over the diagnostic work‐up of males presenting for couple's infertility.

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Correlation among isolated teratozoospermia, sperm DNA fragmentation and markers of systemic inflammation in primary infertile men

Cited by 21 publications

References 53 publications

Kidney function impairment in men with primary infertility: A case–control analysis

Kidney function impairment in men with primary infertility: A case–control analysis

Expanding the spectrum of syndromic PPP2R3C‐related XY gonadal dysgenesis to XX gonadal dysgenesis

High serum alpha‐fetoprotein levels in primary infertile men

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