Correlation analysis between biochemical, functional and structural markers of endothelium damage in patients with essential hypertension

Andor, Minodora; Suciu, Maria; Cristescu, Carmen; Dragan, L.; Vlaia, Lavinia; Vlaia, Vicenţiu; Suciu, Liana; Tomescu, Mirela Cleopatra

doi:10.1016/j.atherosclerosis.2014.05.380

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…According to the latest discoveries, both CNS and increased levels of ANG II and salt from the body are responsible for T-lymphocytes activation, which once activated, reached the peripheral blood vessels, and kidneys start the release of pro-inflammatory cytokines responsible for vasoconstriction and retention of sodium thereby contributing to the long-term maintenance of high BP values, respectively, arterial HT [31,32,36]. Reduction of the inflammatory process at the vascular level both through direct blocking of the production of ANG II by means of pharmacological agents like angiotensin converting enzyme inhibitors (ACE inhibitors) or indirectly by other pharmacological agents such us statins, is associated with the decrease of plasma levels of various pro-inflammatory and pro-coagulant markers from the old, high sensitive C-reactive protein, soluble cellular adhesion molecules of immunoglobulin family, the selectins group, up to long pentraxin 3, a new multimeric inflammatory biomarker, from the family of pentraxins that is nowadays one of the mechanisms of intervention in reducing BP values in hypertensive patients and reduction of the progression of the atherosclerotic process, issue proven by numerous clinical studies [37][38][39].…”

Section: Pathophysiological Changesmentioning

confidence: 99%

Psychosomatic Interrelations in Cardiovascular Diseases and Their Consequences on Patient’s Quality of Life

Suciu¹,

Cristescu²

2017

Well-Being and Quality of Life - Medical Perspective

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At present, the cardiovascular diseases (CVD) are among the major concerns of World Health Organization (WHO), assurance health systems and researchers in the specific field, because they are the number one cause of deaths globally, and according to several perspective studies, they will become the pathology that generates the greatest economic burden worldwide, through morbidity, disability, poor quality of life, and cause of death. Nowadays, the psychic field and the vulnerability of individual mental level to stress are an important link in the development of mental illness, CVD (included in the group of psychosomatic disorders), and also of interrelationship between them. The combined effects of these factors are reflected in the behavioral and cardiovascular (CV) system's pathophysiological changes, which determine the impairment of health-related quality of life for the CV patients, on both short-term and long-term. This chapter aims to address both the interrelationship of psychosocial factors with CVD in terms of its multifactorial etiology and the mark of this bidirectional link on the quality of life of the patients. In several sections, the following issues will be described: general aspects regarding the relationship between homeostasis-stress-pathology; the role of stress as a psychosocial factor in the multifactorial etiology of CVD; the implications of mental disorders in the pathogenesis of CVD; behavioral aspects of CV patient during his illness, and strategies for improving therapeutic adherence and the quality of life of these patients.

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Section: Pathophysiological Changesmentioning

confidence: 99%

Psychosomatic Interrelations in Cardiovascular Diseases and Their Consequences on Patient’s Quality of Life

Suciu¹,

Cristescu²

2017

Well-Being and Quality of Life - Medical Perspective

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“…The advantages of using of serum biomarkers in the assessment of endothelial status are the simplicity of the procedure and the fact that venous blood samples are widely used in laboratory routine [ 22 ]. Moreover, biochemical markers demonstrate an excellent sensitivity in reflecting ED, comparable with biophysical measurements [ 25 , 26 , 27 ]. It is also highly probable that liberation of biochemical markers into circulation by injured endothelial cells may precede the alterations in their function measured by biophysical techniques, such as FMD.…”

Section: Introductionmentioning

confidence: 99%

Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)—A pilot study

Budzyń

Iskra

Turkiewicz³

et al. 2018

PLoS ONE

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BackgroundAlthough the endothelial dysfunction is considered to be implicated in the pathogenesis of chronic venous insufficiency (CVI) the endothelial status in patients with venous disorders is still not fully evaluated. Therefore the aim of the study was to measure the concentration of selected markers of endothelial dysfunction: von Willebrand factor (vWf), soluble P-selectin (sP-selectin), soluble thrombomodulin (sTM) and soluble VE-cadherin (sVE-cadherin) in CVI women who constitute the most numerous group of patients suffering from venous disease.Materials and methodsForty four women with CVI were involved in the study and divided into subgroups based on CEAP classification. Concentration of vWf, sP-selectin, sTM and sVE-cadherin were measured and compared with those obtained in 25 healthy age and sex-matched women.ResultsIt was found that the concentration of sTM increased and sVEcadherin decreased along with disease severity in CVI women. A significant rise of sTM was observed especially in CVI women, with the highest inflammation status reflected by hsCRP or elastase concentration, and in CVI women with a high oxidative stress manifested by an increased plasma MDA. A significant fall of circulating sVE-cadherin was reported in CVI women with moderate to highest intensity of inflammation and oxidative stress. There was no change in vWF and sP-selectin concentration at any stage of CVI severity.ConclusionsThe results of the present study demonstrate the presence of endothelial dysfunction in women suffering from CVI which seems to progress with the disease severity and may be associated with inflammation and enhanced oxidative stress.

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Correlation analysis between biochemical, functional and structural markers of endothelium damage in patients with essential hypertension

Cited by 2 publications

References 14 publications

Psychosomatic Interrelations in Cardiovascular Diseases and Their Consequences on Patient’s Quality of Life

Psychosomatic Interrelations in Cardiovascular Diseases and Their Consequences on Patient’s Quality of Life

Plasma concentration of selected biochemical markers of endothelial dysfunction in women with various severity of chronic venous insufficiency (CVI)—A pilot study

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