Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis

Tang, Ning; Zhang, Yaping; Liu, Zeyu; Fu, Tao; Liang, Qinghong; Ai, Xuemei

doi:10.3892/br.2016.681

Cited by 31 publications

(23 citation statements)

References 12 publications

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“…In addition to the liver stiffness value measured by FibroScan and AST‐to‐platelet ratio, several studies focused on other noninvasive methods for evaluating liver fibrosis in the CHB population, such as the fibrosis index based on 4 factors (age, platelet count, ALT, and AST) and the Forn index (a formula based on the platelet count, γ‐glutamyl transferase, age, and cholesterol). Both of them can detect liver fibrosis successfully .…”

Section: Discussionmentioning

confidence: 99%

Dynamic Changes of the Aspartate Aminotransferase‐to‐Platelet Ratio and Transient Elastography in Predicting a Histologic Response in Patients With Chronic Hepatitis B After Entecavir Treatment

Sun

et al. 2018

J of Ultrasound Medicine

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Objectives To evaluate the dynamic changes of the aspartate aminotransferase (AST)‐to‐platelet ratio and transient elastography (FibroScan; Echosens, Paris, France) in predicting a histologic response in patients with chronic hepatitis B (CHB) after entecavir treatment. Methods A total of 148 patients with CHB were enrolled. Patient information was collected. All patients received liver biopsy and FibroScan before and after 96 weeks of entecavir treatment. Results Baseline liver biopsy results showed that there were 7 patients without liver fibrosis (fibrosis stage F0; 4.7%), 51 patients with mild liver fibrosis (F1; 34.5%), and 90 patients with advanced liver fibrosis (>F1; 60.9%). The liver stiffness value and AST‐to‐platelet ratio increased significantly as the METAVIR score of the patients increased from F0 to F4 (P < .001). After antiviral therapy for 96 weeks, the average liver stiffness value measured by FibroScan and the AST‐to‐platelet ratio showed a significant decrease. When we use a decreased liver stiffness value to predict a histologic response, the area under the receiver operating characteristic curve was 0.70 (95% confidence interval, 0.61–0.79; P < .001), and the sensitivity and specificity were 74.3% and 68.8%, respectively. The decrease of the AST‐to‐platelet ratio also could predict the histologic response of patients with CHB; the area under the receiver operating characteristic curve was 0.77 (95% confidence interval, 0.69–0.86; P < .001) with sensitivity of 76.2% and specificity of 70.2%. A multivariate analysis indicated that a high hepatitis B virus DNA viral load (odds ratio, 1.44; P = .04) and high METAVIR score (odds ratio, 1.38; P = .02) were independent risk factors for the histologic response. Conclusions Both the AST‐to‐platelet ratio and FibroScan value can effectively predict a histologic response in patients with CHB during entecavir treatment. Therefore, they can be used to monitor these patients during antiviral treatment to avoid multiple liver biopsies.

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Section: Discussionmentioning

confidence: 99%

Dynamic Changes of the Aspartate Aminotransferase‐to‐Platelet Ratio and Transient Elastography in Predicting a Histologic Response in Patients With Chronic Hepatitis B After Entecavir Treatment

Sun

et al. 2018

J of Ultrasound Medicine

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“…Detection kits specific for liver function biomarkers [alanine aminotransferase (ALT); aspartate aminotransferase (AST); total bilirubin (TBIL); direct bilirubin (DBIL); indirect bilirubin (IBIL); γ-glutamyl transferase (γ-GT); cholinesterase (CHE); and total bile acids (TBA)] were purchased from Johnson & Johnson (New Brunswick, NJ, USA) and used in conjunction with an automatic biochemical analyzer (AU5400TM; Olympus Corporation, Tokyo, Japan). Blood samples were collected from each mouse and processed as previously described (5). Measurements of liver function biomarkers were based on assays using the initial rate method (5), and measurements of TBIL, DBIL and IBIL were based on colorimetric assays.…”

Section: Methodsmentioning

confidence: 99%

“…Blood samples were collected from each mouse and processed as previously described (5). Measurements of liver function biomarkers were based on assays using the initial rate method (5), and measurements of TBIL, DBIL and IBIL were based on colorimetric assays.…”

Section: Methodsmentioning

confidence: 99%

Correlation of four potential biomarkers of liver fibrosis with liver function and grade of hepatic fibrosis in a neonatal cholestatic rat model

Zhang

Liu

et al. 2017

Molecular Medicine Reports

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The present study investigated the correlation between four serum biomarkers of liver fibrosis, liver function and pathological hepatic fibrosis grade in neonatal cholestatic rats. A total of 38 Sprague‑Dawley rats, aged 3 weeks, were randomly assigned to the experimental group (EG), control group (CG) and the blank control group (BCG). EG received intragastric administration of 1% α‑naphthylisothiocyanate, 75 mg/kg, to induce acute cholestasis liver injury, CG and BCG were set as control groups. Blood samples from all groups were collected 48 h following the procedure. The levels of liver function markers, and four biomarkers of liver fibrosis in serum, were measured and sections of liver tissue were stained for pathological analysis. The results of the present study demonstrated that the degree of hepatic fibrosis in EG, in the serum levels or by pathological analysis, was markedly more evident compared with the CG. Several indices of four biomarkers for liver fibrosis in serum were identified and correlated with the levels of liver function markers. The pathological hepatic fibrosis grade was correlated with γ‑glutamyl transferase (γ‑GT) and Hyaluronic acid (HA). Therefore, HA and γ‑GT were positively correlated with the grade of hepatic fibrosis, indicating their efficacy as biomarkers of infantile cholestatic hepatic fibrosis.

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“…The increase of their activities frequently reminds the potential hepatoxicity [35]. TBIL concentration in blood is related to the excreting ablility of bilirubin from liver to blood [36]. The increasing level of BUN usually indicates the nephrotoxicity.…”

Section: Urinalysis and Biochemistrymentioning

confidence: 99%

The Excretion of BRCAA Antibody-Conjugated Gold Nanoclusters from Kidneys of Treated Rats

Liu¹,

Li²,

Wu³

et al. 2017

Nano BioMed ENG

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The gold nanoclusters (Au-NCs) have emerged for delivery of various payloads such as small molecular drug and big molecular proteins due to their low immunogenicity, quick clearance and good biocompatibility. Even though they have shown great prospective in biomedical area, there are also some security problems which should be investigated further more. BRCAA1 mAb Au-NCs is a probe for gastric cancer diagnosis prepared by conjugating BRCAA1 monoclonal antibody with fluorescent Au-NCs. In this research, the renal excretion and effect on glomerulus filtration of BRCAA1 mAb AuNCs in rats were investigated. The result indicated that BRCAA1 mAb Au-NCs could be eliminated through the glomerulus filtration as early as 2 hr after the administration following the excretion of other proteins in the plasma such as immunoglobulin. Electron microscope image and pathological analysis of kidney showed that BRCAA1 mAb Au-NCs induced some structural injury such as capillaries endotheliocyte damage, pycnosis, karyorrhexis and hyalomitome acidophilia enhancement. Biochemical indexes including ALT, AST, BUN, TBIL, CK and CREA are abnormal in the period of 2 to 48 hr after the administration. The results of Western blotting and immunohistochemisty show the downregulation of three key proteins (ZO-1, Nephrin and Podocin) indicating the influence of BRCAA1 mAb Au-NCs on the foot processes of glomerular epithelial cells and shallow intercellular junctions or slit diaphragms.

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Correlation analysis between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis

Abstract: Abstract. The aim of the present study was to investigate the correlation between four serum biomarkers of liver fibrosis and liver function in infants with cholestasis.

Cited by 31 publications

References 12 publications

Dynamic Changes of the Aspartate Aminotransferase‐to‐Platelet Ratio and Transient Elastography in Predicting a Histologic Response in Patients With Chronic Hepatitis B After Entecavir Treatment

Dynamic Changes of the Aspartate Aminotransferase‐to‐Platelet Ratio and Transient Elastography in Predicting a Histologic Response in Patients With Chronic Hepatitis B After Entecavir Treatment

Correlation of four potential biomarkers of liver fibrosis with liver function and grade of hepatic fibrosis in a neonatal cholestatic rat model

The Excretion of BRCAA Antibody-Conjugated Gold Nanoclusters from Kidneys of Treated Rats

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