Correlation analysis between phenolic levels of Brazilian propolis extracts and their antimicrobial and antioxidant activities

Silva, Joaquim Fernando Mendes da; Souza, Maria Clara de; Matta, Samara Ramalho; Andrade, Marisol Ribeiro de; Vidal, Flavia Vila Nova

doi:10.1016/j.foodchem.2005.07.055

Cited by 159 publications

(115 citation statements)

References 24 publications

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“…In addition, other metabolites in plants besides phenols and flavonoids could contribute to the antioxidant activity and wound healing. The results found in the present work could be related to phenols, flavonoids and other metabolites [51] [52].…”

Section: Discussionsupporting

confidence: 70%

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FTIR analysis and quantification of phenols and flavonoids of five commercially available plants extracts used in wound healing

et al. 2016

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Natural products are used in wound healing in order to prevent infection. Propolis is a well known antimicrobial with phenolic compounds and flavonoid content which vary according to the propolis origin. Besides propolis (from both Brazilian and UK sources), pomegranate, dragon's blood and sage are possible antimicrobials to be used in biomaterials. The goal of this work was to analyze the amount of phenols and flavonoid compounds in these natural products, their antioxidant activities and the bonds present by FTIR. The FTIR analysis revealed the presence of active compounds in all drug samples. The phenols quantification showed that Brazilian propolis was rich in phenols compared to the other drugs, followed by pomegranate and UK propolis. UK propolis was the most rich in flavonoids, which is expected on account of its origin. Pomegranate, UK propolis and Dragon's blood presented the highest antioxidant activity. All samples presented antioxidant activity > 82%.

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Section: Discussionsupporting

confidence: 70%

“…The amount of phenolic compounds was higher in Brazilian propolis than in UK one (p < 0.04). Propolis from tropical zones usually present high phenolic compounds compared to propolis from tempered zones, rich in flavonoids [35]. Pomegranate has amount of phenols similar to propolis.…”

Section: Discussionmentioning

confidence: 99%

FTIR analysis and quantification of phenols and flavonoids of five commercially available plants extracts used in wound healing

et al. 2016

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“…The crude extract Oak1, as well as fractions Oak1_F4 and Oak1_F5, all presenting a strong anti-oxidant potency, appear to be quite rich in polyphenolic compounds; such correlation between chemical composition and antioxidant activity was already reported in the literature [50][51][52]. HPLC-ESI-MS analysis of fraction Oak1_F4 reveals that it is mainly constituted of catechin, a flavanol already known to act as a powerful antioxidant [53].…”

Section: Fractionation Schemementioning

confidence: 54%

Development of a Natural Anti-Age Ingredient Based on Quercus pubescens Willd. Leaves Extract—A Case Study

Plainfossé

Burger²,

Azoulay

et al. 2018

Cosmetics

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Abstract:Consumers pay more and more attention not just to the safety and health aspects of ingredients entering their cosmetics' formulations, but also to their potency, origin, processing, ethical value and environmental footprint. Sustainability of the supply chain, preservation of biodiversity, as well as greener extraction techniques are hence very popular with consumers. Consumers are primarily concerned by the efficacy of the cosmetic products they use and continuously scrutinize product labels, so marketing arguments need to be based on rigorous testing and reliable results to support claims (anti-age, anti-pollution, etc.) displayed on the product's packaging. As a result, the increasing demand for natural ingredients with assessed bioactivities has profoundly modified the strategies adopted by cosmetic professionals to innovate in terms of actives. Sourcing and developing new natural cosmetic actives is a long-term procedure that is thoroughly described in the present paper, via the example of the design of both liquid and solid ingredients based on Quercus pubescens Willd. leaves extract, for which anti-age properties were assessed by a combination of in vitro assays.

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“…However, different substances may be involved in the biological activities that we analyzed (antimicrobial and cytotoxic), including Hyperibone A (Castro et al, 2009), because we observed that G6 propolis, which has the lowest phenolic compound and flavonoid contents, showed the best antibacterial and cytotoxic effects. Silva et al (2006) established the correlation between the levels of phenolics and flavonoids with antioxidant and antimicrobial activities of 49 samples of Brazilian propolis. They demonstrated that the level of these compounds does not directly reflect the biological activity of the propolis extracts.…”

Section: Resultsmentioning

confidence: 99%

The correlation between the phenolic composition and biological activities of two varieties of Brazilian propolis (G6 and G12)

Cabral

Oldoni

Alencar

et al. 2012

Braz. J. Pharm. Sci.

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Biological assays that have been performed on different types of Brazilian propolis have shown that type 6 propolis (G6) has a strong antimicrobial activity and a low flavonoid content. This study aimed to evaluate the correlation between the phenolic composition and the biological activities displayed by propolis G6 from the state of Bahia and green propolis, also known as type 12 (G12). The values of the flavonoids and the total phenolics in propolis G6 were different than those in propolis G12. Although the G12 variety presented greater antioxidant activity, propolis G6 proved to have greater antimicrobial and cytotoxic activities. The results showed that the phenolic compounds may not be the only compounds responsible for the biological activity. More detailed studies of the chemical composition and an assessment of the biological activity are required to establish the quality of propolis.Uniterms: Brazilian própolis/evaluation. Flavonoids/determination in propolis. Phenolic compounds/ determination in propolis. Propolis/quality control.Ensaios biológicos realizados com diferentes tipos de própolis brasileira têm mostrado que a própolis do tipo 6 (G6) tem forte atividade antimicrobiana e menor teor de flavonóides. Este trabalho teve como objetivo avaliar a correlação entre a composição fenólica e atividades biológicas apresentadas pela própolis G6, do Estado da Bahia, e a própolis verde, do tipo 12 (G12). Os teores de flavonóides e fenólicos totais na própolis G6 foram diferentes dos teores da própolis G12. Apesar da G12 apresentar maior atividade antioxidante, a própolis G6 apresenta maior atividade antimicrobiana e citotóxica. Os resultados mostraram que os compostos fenólicos não são os únicos compostos responsáveis pela atividade biológica da própolis. Estudos mais específicos da composição química, em adição à avaliação das atividades biológicas, são requeridos para determinar a qualidade da própolis.Unitermos: Própolis brasileira/avaliação. Flanovóides/determinação no própolis. Compostos fenólicos/ determinação no própolis. Própolis/controle de qualidade.

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Correlation analysis between phenolic levels of Brazilian propolis extracts and their antimicrobial and antioxidant activities

Cited by 159 publications

References 24 publications

FTIR analysis and quantification of phenols and flavonoids of five commercially available plants extracts used in wound healing

FTIR analysis and quantification of phenols and flavonoids of five commercially available plants extracts used in wound healing

Development of a Natural Anti-Age Ingredient Based on Quercus pubescens Willd. Leaves Extract—A Case Study

The correlation between the phenolic composition and biological activities of two varieties of Brazilian propolis (G6 and G12)

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