Correlation analysis between single nucleotide polymorphisms of pulmonary surfactant protein A gene and pulmonary tuberculosis in the Han population in China

Yang, Huanming; Li, Hui; Wang, Yige; Xu, Chaoyang; Zhao, Yong; Ma, Xiaolong; Li, Xiaowen; Chen, Hui

doi:10.1016/j.ijid.2014.03.1395

Cited by 16 publications

(14 citation statements)

References 36 publications

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“…In a Chinese population, the polymorphism 1649G in the SP-A2 gene was strongly associated with tuberculosis, mirroring the findings in the Ethiopian and Indian populations (Yang et al 2014). The SP-A2 1649G leads to a transversion (proline to alanine), affecting the triple helical structure of SP-A (Yang et al 2014). In SP-D, the polymorphism, G459A, is significantly associated with tuberculosis susceptibility in an Indian population, but the molecular basis for susceptibility is not understood (Vaid et al 2006).…”

Section: Sp-a and Sp-dsupporting

confidence: 71%

“…Another study also found two polymorphisms (SP-A2 G1649C and SP-A2 A1660G) in the introns of SP-A1 that were associated with tuberculosis in an Indian population, but none in the SP-A1 gene (Madan et al 2002). In a Chinese population, the polymorphism 1649G in the SP-A2 gene was strongly associated with tuberculosis, mirroring the findings in the Ethiopian and Indian populations (Yang et al 2014). The SP-A2 1649G leads to a transversion (proline to alanine), affecting the triple helical structure of SP-A (Yang et al 2014).…”

Section: Sp-a and Sp-dmentioning

confidence: 60%

“…A number of studies have described polymorphisms in these genes and the SP-D gene which may have a role in susceptibility to microbial infection, particularly tuberculosis. Polymorphisms within and flanking the SP-A1 and SP-A2 genes have been described which indicate protection or susceptibility toward pulmonary TB in the populations studied in Mexico, Ethiopia, India and China (Floros et al 2000;Madan et al 2002;Malik et al 2006;Vaid et al 2006;Yang et al 2014). Two SP-A1 alleles (SFTPA1 307A, SFTPA1 776T) and two SP-A2 alleles (SFTPA2 355C and SFTPA2 751C) were associated with tuberculosis susceptibility in Ethiopia (Malik et al 2006).…”

Section: Sp-a and Sp-dmentioning

confidence: 97%

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Collectins: Innate Immune Pattern Recognition Molecules

Murugaiah

Tsolaki

Kishore

2020

Advances in Experimental Medicine and Biology

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Collectins are collagen-containing C-type (calcium-dependent) lectins which are important pathogen pattern recognising innate immune molecules. Their primary structure is characterised by an N-terminal, triple-helical collagenous region made up of Gly-X-Y repeats, an a-helical coiled-coil trimerising neck region, and a Cterminal C-type lectin or carbohydrate recognition domain (CRD). Further oligomerisation of this primary structure can give rise to more complex and multimeric structures that can be seen under electron microscope. Collectins can be found in serum as well as in a range of tissues at the mucosal surfaces. Mannanbinding lectin can activate the complement system while other members of the collectin family are extremely versatile in recognising a diverse range of pathogens via their CRDs and bring about effector functions designed at the clearance of invading pathogens. These mechanisms include opsonisation, enhancement of phagocytosis, triggering superoxidative burst and nitric oxide production. Collectins can also potentiate the adaptive immune response via antigen presenting cells such as macrophages and dendritic cells through modulation of cytokines and chemokines, thus they can act as a link between innate and adaptive immunity. This chapter describes the structure-function relationships of collectins, their diverse functions, and their interaction with viruses, bacteria, fungi and parasites.

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Section: Sp-a and Sp-dsupporting

confidence: 71%

Section: Sp-a and Sp-dmentioning

confidence: 60%

Section: Sp-a and Sp-dmentioning

confidence: 97%

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Collectins: Innate Immune Pattern Recognition Molecules

Murugaiah

Tsolaki

Kishore

2020

Advances in Experimental Medicine and Biology

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“…Positive samples were then evaluated by employing the Mycobacterial Growth Indicator Tube 960 broth system culture (MGIT, Becton Dickinson, Franklin Lakes, USA) using the following concentrations: 4 first line anti-TB drugs, isoniazid (INH) 0.2 μg/ml, rifampin (RFP) 1.0 μg/ml, streptomycin (SM) 2.0 μg/ml, ethambutol (EMB) 7.5 μg/ml; and 7 second line anti-TB drugs, ofloxacin (Ofx) 2.0 μg/ml, capreomycin (Cm) 20.0 μg/ml, kanamycin (Km) 30.0 μg/ml, amikacin (Am) 40.0 μg/ml, paminosalicylic acid (PAS) 2.0 μg/ml, ethionamide (Eto) 40.0 μg/ml and cycloserine (Cs) 40.0 μg/ml. Isolates were considered resistant to a particular drug if the growth rate was more than 1% compared with the control or sensitive if the growth rate was less than 1% compared with the control [ 7 , 14 ]. The definition of MDR TB is a strain that is resistant to at least two first-line drugs (INH and RFP).…”

Section: Methodsmentioning

confidence: 99%

Correlations between Drug Resistance of Beijing/W Lineage Clinical Isolates of Mycobacterium tuberculosis and Sublineages: A 2009–2013 Prospective Study in Xinjiang Province, China

Wang

Han

et al. 2015

Med Sci Monit

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BackgroundThe prevalence of drug-resistant tuberculosis (TB) in Xinjiang is higher than in other regions of China, and Beijing/W lineage Mycobacterium tuberculosis (MTB) is the dominant strain of MTB in Xinjiang. However, information on multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB, particularly the correlation between MDR and the Beijing/W lineage and the correlation between drug resistance and the Beijing/W sublineage strains, is limited.Material/MethodsWe conducted a prospective study to describe the prevalence of MDR/XDR TB, Beijing/W lineage and sublineage strains in Xinjiang in China from 2009 to 2013. All MTB underwent drug susceptibility testing to the first- and second-line anti-tuberculosis drugs. The Beijing/W lineages and sublineages were detected by large-sequence polymorphisms with polymerase chain reaction.ResultsA total of 410 clinical isolates were identified. The overall percentage of MDR and XDR cases in Xinjiang was 13.2% (54/410) and 13.0% (7/54), respectively. Overall, 9.8% (14/143) of the Beijing lineage MTB were MDR patients, and 15.6% (40/257) of the Non-Beijing lineage MTB were MDR patients. In the 143 Beijing MTB lineages, 11.2% isolates were in sublineage 105, 15.4% isolates were in sublineage 207, 69.2% isolates were in sublineage 181, and 4.2% isolates were in sublineage 150. None of the isolates were detected in sublineage 142. Significant differences between the Beijing/W and non-Beijing/W strains were observed regarding INH and EMB resistance, respectively.ConclusionsThe prevalence of the MDR TB in Xinjiang remains high and imposes challenges for TB control. Four Beijing/W sublineage isolates were observed in Xinjiang. There was no correlation between MDR and the Beijing/W lineage and no correlation between drug resistance and the Beijing/W sublineage strains. Surveillance of the clinical isolates of MTB is recommended to strengthen the identification of MDR/XDR TB and sublineages of the Beijing/W strains.

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“…SNPs in the SFTPA1 and SFTPA2 genes encoding pulmonary surfactant protein A (SPA) were found to be associated with pulmonary tuberculosis in the Han population in China. The G allele of rs17886395, T allele of rs1965707 and haplotype CCAAC–CGCA in combination with SFTPA1 and SFTPA2 were found to be risk factors, while haplotype CGAAC ( SFTPA1 ) – AGCC ( SFTPA2 ) and TCGAT- ACCC were found to be protective for pulmonary tuberculosis (Yang et al, 2014a). In other study the T allele of rs1914663 in the SFTPA gene was found to associate with increased risk of TB, whereas the TC+TT genotype was found to be higher in PTB and non-severe TB, as compare to controls, in the Han Chinese population (Li et al, 2016) (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Immune-related gene polymorphisms in pulmonary diseases

et al. 2017

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Between the DNA sequences of two randomly-selected human genomes, which consist of over 3 billion base pairs and twenty five thousand genes, there exists only 0.1% variation and 99.9% sequence identity. During the last couple of decades, extensive genome-wide studies have investigated the association between single-nucleotide polymorphisms (SNPs), the most common DNA variations, and susceptibility to various diseases. Because the immune system's primary function is to defend against myriad infectious agents and diseases, the large number of people who escape serious infectious diseases underscores the tremendous success of this system at this task. In fact, out of the third of the global human population infected with Mycobacterium tuberculosis during their lifetime, only a few people develop active disease, and a heavy chain smoker may inexplicably escape all symptoms of chronic obstructive pulmonary disease (COPD), lung cancer, and other smoke-associated lung diseases. This may be attributable to the genetic makeup of the individual(s), including their SNPs, which provide some resistance to the disease. Pattern recognition receptors (PRRs), transcription factors, cytokines and chemokines all play critical roles in orchestrating immune responses and their expression/activation is directly linked to human disease tolerance. Moreover, genetic variations present in the immune-response genes of various ethnicities may explain the huge differences in individual outcomes to various diseases and following exposure to infectious agents. The current review focuses on recent advances in our understanding of pulmonary diseases and the relationship of genetic variations in immune response genes to these conditions.

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Correlation analysis between single nucleotide polymorphisms of pulmonary surfactant protein A gene and pulmonary tuberculosis in the Han population in China

Abstract: SNP in SP-A is associated with PTB in the Han population in China. The G allele at aa91, T allele at aa140, and haplotype 6A11-1A8 are risk factors for PTB, but haplotype CGAAC-1A(0) and 6A(4)-1A(12) are protective factors for PTB.

Cited by 16 publications

References 36 publications

Collectins: Innate Immune Pattern Recognition Molecules

Collectins: Innate Immune Pattern Recognition Molecules

Correlations between Drug Resistance of Beijing/W Lineage Clinical Isolates of Mycobacterium tuberculosis and Sublineages: A 2009–2013 Prospective Study in Xinjiang Province, China

Immune-related gene polymorphisms in pulmonary diseases

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