Correlation analysis of I-131 SPECT/CT uptake parameters with the success ablation treatment of thyroid remnant in patients with low-intermediate-risk differentiated thyroid cancer

Zhang, Qian; Xu, Wei

doi:10.1097/mnm.0000000000001604

Cited by 2 publications

(8 citation statements)

References 20 publications

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“…However, research on the quantitative parameters of SPECT/CT imaging 3 days after RAI adjuvant therapy has been relatively limited. Recently, studies have found that these parameters are associated with the efficacy of ablation therapy, and %ID was found to be a predictor of the successful outcome of ablation therapy in patients with DTC ( 6 ). Additionally, quantitative evaluation could serve as a predictive indicator for the disappearance of RAI accumulation in the thyroid bed after RAI adjuvant therapy ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

“…SPECT image reconstruction was performed by employing the ordered subset expectation maximization algorithm (OSEM) with 2 iterations and 10 subsets. Additional corrections, including scattering correction, sensitivity recovery, and attenuation correction based on CT data, were also performed ( 6 ).…”

Section: Methodsmentioning

confidence: 99%

“…For most patients, the value of NM threshold was 0.4, but a few patients had the values adjusted to 0.2 to ensure that the halation observed in thyroid uptake in SPECT/CT included all lesions but excluded any halation extending outside the body. The software measured the SUVmax, SUVmean, %ID, and the volume of thyroid remnant VOIs ( 6 ). A typical graph is shown in Figure 1 .…”

Section: Methodsmentioning

confidence: 99%

“…SUV referred to the ratio of the total radioactive uptake in the VOIs to the total administered radioactive dose per unit of body weight. The %ID referred to the ratio of the total radioactivity of VOIs to the total administered radioactivity ( 6 ).…”

Section: Methodsmentioning

confidence: 99%

“…In recent years, single-photon emission computed tomography-computed tomography (SPECT/CT) has been proven to be capable of accurately quantifying the radioactive isotope uptake with the development of advanced software ( 6 ). These software packages allow for the measuring of quantitative parameters such as standardized uptake values (SUV) and absolute radioactivity concentration at uptake sites ( 7 - 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Correlation analysis between the quantitative parameters of iodine-131 single-photon emission computed tomography-computed tomography thyroid bed uptake and the efficacy of radioactive iodine adjuvant therapy for papillary thyroid cancer

Mao,

Lin,

Wang

et al. 2024

Quant Imaging Med Surg

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Background Single-photon emission computed tomography-computed tomography (SPECT/CT) quantification has emerged as a valuable tool for assessing disease prognosis by accurately identifying and characterizing abnormal lesions with accumulated radionuclides. Papillary thyroid carcinoma (PTC) is the most prevalent type of thyroid cancer, and radioactive iodine (RAI) therapy is a standard treatment following total thyroidectomy. This study aimed to explore the potential utility the quantitative parameters of the thyroid bed under iodine-131 (I-131) SPECT/CT in the efficacy of RAI adjuvant therapy for patients with PTC. Methods The retrospective cohort study enrolled 107 patients with PTC who underwent RAI adjuvant therapy from June 2020 to January 2023. Three days after the RAI adjuvant therapy, all patients underwent I-131 whole-body scans and SPECT/CT imaging. The quantitative parameters, including maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), and percent injected dose (%ID), were measured using image analysis software based on I-131 SPECT/CT thyroid bed uptake. Successful therapy was defined as inhibitory thyroglobulin (Tg) <0.2 ng/mL with negative thyroglobulin antibody (TgAb) and negative imaging examination 6 months after RAI adjuvant therapy. The relationship between the quantitative parameters and the treatment efficacy, in addition to the potential influencing factors, were analyzed. Results The quantitative parameters from the successful group [SUVmax: median 6.15 g/mL, interquartile range (IQR) 2.34–13.80 g/mL; SUVmean: median 2.02 g/mL, IQR 0.89–4.93 g/mL; %ID: median 2.00%, IQR 1.00–4.00%] were significantly lower than those from the unsuccessful group (SUVmax: median 19.03 g/mL, IQR 5.31–45.10 g/mL, SUVmean 4.64 g/mL, IQR 2.07–19.05 g/mL; %ID: median 8.00%, IQR 3.00–18.00%) (SUVmax: Z=−3.755; SUVmean; Z=−3.671; %ID: Z=−4.070; all P values <0.001). SUVmax, SUVmean and %ID were positively correlated with the stimulated thyroglobulin (sTg) and inhibitory Tg at 6 months after RAI adjuvant therapy, respectively (all P values <0.001). SUVmax [odds ratio (OR) =1.045], SUVmean (OR =1.130), and %ID (OR =1.092) were predictive factors for the failure of RAI adjuvant therapy (all P values <0.001). Conclusions Our study suggested that quantitative parameters (SUVmax, SUVmean, and %ID) derived from I-131 SPECT/CT imaging of the thyroid bed can serve as useful tools for predicting therapy outcomes following RAI adjuvant therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Correlation analysis between the quantitative parameters of iodine-131 single-photon emission computed tomography-computed tomography thyroid bed uptake and the efficacy of radioactive iodine adjuvant therapy for papillary thyroid cancer

Mao,

Lin,

Wang

et al. 2024

Quant Imaging Med Surg

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Prognosis and ablation success in thyroid cancer: overcoming the challenges of incomplete clinical profiles

Ora,

Nazar,

Mishra

et al. 2024

Nuclear Medicine Communications

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Background Differentiated thyroid carcinoma (DTC) is managed by surgery followed by radioiodine (RAI) therapy in most intermediate and high-risk patients. Most nonmetastatic patients have excellent treatment responses and have long-term disease-free status. A lack of comprehensive medical services in resource-limited nation leads to attrition of critical clinical prognostication information. This study aimed to identify readily available clinical, biochemical, and histopathological parameters to predict remnant ablation success and long-term outcomes. Methods The study included DTC patients who underwent RAI after surgery. Ablation success was determined by thyroglobulin (Tg) and whole-body radioiodine scan. Patients were followed for at least 5 years to assess biochemical incomplete response (BIR) and structural recurrence. Results The study included 383 patients (a mean age of 37.8 ± 12.9 years). Successful ablation was noted in 251 (65.5%). High preablative stimulated serum Tg (presTg), papillary variants, and central and lateral compartment lymph nodal metastases were associated with ablation failure. PresTg (P < 0.001) was the most significant predictor. After a 102.9 ± 34.5 months follow-up, 280 (73.1%) patients were disease-free. BIR and structural recurrence were noted in 103 and 32 patients. PresTg (8.1 ± 27.7 vs. 92.3 ± 99.9 ng/ml), ATg (112.9 ± 389.8 vs. 43.2 ± 89.8 IU/ml), papillary variant, central [109 (66.1%) vs. 56 (33.9%)], and lateral compartment [65 (63.7%) vs. 37 (36.3%) lymph nodal metastases were associated (P < 0.05) with BIR. PresTg >10.5 has a sensitivity and specificity of 86.6 and 86.0% for predicting BIR. Patients with successful remnant ablation and a presTg level <10.5 ng/ml had a low risk of long-term disease recurrence (less than 5%). Conclusion This ambispective study found that successful ablation and long-term disease-free survival were achievable in a significant proportion of DTC patients. BIR (26.9%) and structural recurrence (8.4%) were not uncommon. PresTg levels emerged as a crucial predictor of ablation success and subsequent outcomes. In resource-limited regions, presTg levels and ablation failure can aid in optimizing treatment strategies and improving patient care.

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Correlation analysis of I-131 SPECT/CT uptake parameters with the success ablation treatment of thyroid remnant in patients with low-intermediate-risk differentiated thyroid cancer

Cited by 2 publications

References 20 publications

Correlation analysis between the quantitative parameters of iodine-131 single-photon emission computed tomography-computed tomography thyroid bed uptake and the efficacy of radioactive iodine adjuvant therapy for papillary thyroid cancer

Correlation analysis between the quantitative parameters of iodine-131 single-photon emission computed tomography-computed tomography thyroid bed uptake and the efficacy of radioactive iodine adjuvant therapy for papillary thyroid cancer

Prognosis and ablation success in thyroid cancer: overcoming the challenges of incomplete clinical profiles

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