Correlation analysis of lipid accumulation index, triglyceride-glucose index and H-type hypertension and coronary artery disease

Yuan, Wenwen; Shao, Yan; Zhao, Dong; Zhang, Bin

doi:10.7717/peerj.16069

Cited by 4 publications

(2 citation statements)

References 21 publications

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“…This is generally consistent with previous research findings, and if there are variations in influencing factors, they should be considered from the perspective of individual pathophysiology and lifestyle [ 25 , 26 ]. The study suggests that TG and LDL-C are independent variables influencing disease progression [ 27 ]. Meta-analysis results indicate that in the overall genetic model of the human population, individuals carrying the TT genotype have an increased risk of developing H-type hypertension [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Analysis of MTHFR C677T genotype and related factors in H-type hypertension in Tibet, China

Yan,

Zhang,

Zhou

et al. 2024

BMC Cardiovasc Disord

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Background and aims H-type hypertension is essential hypertension combined with high homocysteine, and both synergistically increase the risk of cardiovascular and cerebrovascular events. The aim of this study was to investigate the risk factors of H-type hypertension in Tibetan plateau population and correlation with MTHFR C677T gene. Methods and results A multi-stage cluster random sampling method was used to select the research subjects in Tibet Autonomous Region from June 2020 to November 2021. Among Tibetans, the incidence of H-type hypertension accounted for 84.31% of hypertensive patients. The logistic regression analysis demonstrated that age, uric acid (UA), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C) were risk factors for the prevalence of H-type hypertension, the OR (95% CI) was 1.083(1.073–1.094), 1.002(1.001–1.004), 1.240(1.050–1.464) and 2.274(1.432–3.611), respectively. MTHFR C677T TT genotype patients with H-type hypertension OR (95% CI) was 1.629(1.004–2.643). Based on this, a nomogram model was established, and the reliability of the model was proved by area under ROC curve, Brier score and average absolute error. The model’s results indicate that for every five years of age, the score increases by 6 points; for a 2mmol/L increase in TG, the score increases by 5.5 points; for a 1mmol/L increase in LDL-C, the score increases by 10 points; and individuals with the TT genotype receive 8 points. The higher the score, the greater the risk of disease. Conclusion The MTHFR C677T TT genotype is a risk locus for Tibetan patients with H-type hypertension, with age, TG, and LDL-C were identified as risk factors for the disease.

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Section: Discussionmentioning

confidence: 99%

Analysis of MTHFR C677T genotype and related factors in H-type hypertension in Tibet, China

Yan,

Zhang,

Zhou

et al. 2024

BMC Cardiovasc Disord

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“…This ultimately leads to the development of cardiovascular events, suggesting an association between HHcy and high TG (24). At the same time, a large number of epidemiological studies have shown that most hypertensive patients have dyslipidemia (25) and it has been demonstrated that lipid accumulation index (LAP) levels are higher in patients with H-type hypertension than in patients with non-H-type hypertension (26). Clinical observations have shown that hypertensive patients with elevated Hcy levels are positively associated with insulin resistance and diabetes mellitus (27)(28)(29), suggesting an association between FPG and H-type hypertension.…”

Section: Discussionmentioning

confidence: 99%

Association between triglyceride glucose index and H-type hypertension in postmenopausal women

Ding,

Du,

Yang

et al. 2023

Front. Cardiovasc. Med.

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BackgroundRecent studies have reported better predictive performance of triglyceride glucose (TyG) index for cardiovascular events in women, however, whether this association persists in postmenopausal women is inconclusive. We investigated the association between TyG index and H-type hypertension (HHT) in postmenopausal women.Methods1,301 eligible women with hypertension were included in this cross-sectional study. Concomitant homocysteine levels >10 μmol/L were defined as H-type hypertension. The TyG index was calculated as ln [triglycerides (mg/dl) × fasting glucose (mg/dl)/2]. Multivariable logistic regression models and restricted cubic spline models were used to assess the association between TyG index and H-type hypertension in postmenopausal women, and subgroup analyses were performed for potential confounders.ResultsOf the 1,301 hypertensive patients, 634 (48.7%) participants had H-type hypertension. In each adjusted model, TyG index was significantly associated with the risk of H-type hypertension. each 1-unit increase in TyG index was associated with an increased risk of H-type hypertension in all participants (OR = 1.6; 95% CI, 1.3–2.0; P < 0.001), and there was a linear relationship between TyG index and H-type hypertension (P for linear trend < 0.001).ConclusionTyG index is positively associated with H-type hypertension in postmenopausal women, suggesting that TyG index may be a promising marker for H-type hypertension. By controlling lipid levels and blood glucose levels, it may help prevent H-type hypertension in postmenopausal women.

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Association of the triglyceride glucose index with myocardial ischemia in patients with minimal to moderate coronary artery disease

Huang,

Tang,

Ding

et al. 2024

Sci Rep

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The triglyceride glucose (TyG) index has been suggested as a reliable substitute to indicate insulin resistance. Several studies have identified the association between the TyG index and cardiovascular disease. However, the association between the TyG index and the incidence of myocardial ischemia in patients with minimal to moderate coronary artery disease (CAD) has not been clearly assessed. We aimed to investigate the association between the TyG index and the incidence of myocardial ischemia in patients with minimal to moderate CAD. A total of 1,697 patients who underwent coronary computed tomography angiography (CTA) examinations and had minimal to moderate CAD were retrospectively included in the study. The TyG index and computed tomography–derived fractional flow reserve (CT-FFR) were used to assess insulin resistance (IR) and myocardial ischemia, respectively. Myocardial ischemia was defined as a CT-FFR value ≤ 0.80. Logistic regression models were used to explore the associations between the TyG index and myocardial ischemia. The incidence of myocardial ischemia was higher in the highest TyG index tertile (T3) group than in the lowest TyG index tertile (T1) group. After adjusting for other variables, the T3 group remained associated with a higher risk of myocardial ischemia than the T1 group did (OR, 1.43; 95% CI, 1.01–2.04; p = 0.047). A 1- standard deviation (SD) increase in the TyG index was correlated with a 19–24% elevated risk of myocardial ischemia when regarding the TyG index was considered as a continuous variable. Subgroup analysis revealed similar effects. A TyG index is associated with a higher risk of myocardial ischemia detected by CT-FFR in patients with minimal to moderate CAD.

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Correlation analysis of lipid accumulation index, triglyceride-glucose index and H-type hypertension and coronary artery disease

Cited by 4 publications

References 21 publications

Analysis of MTHFR C677T genotype and related factors in H-type hypertension in Tibet, China

Analysis of MTHFR C677T genotype and related factors in H-type hypertension in Tibet, China

Association between triglyceride glucose index and H-type hypertension in postmenopausal women

Association of the triglyceride glucose index with myocardial ischemia in patients with minimal to moderate coronary artery disease

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