Correlation analysis of long non‐coding RNA TUG1 with disease risk, clinical characteristics, treatment response, and survival profiles of adult Ph⁻ Acute lymphoblastic leukemia

Abstract

Background Long non‐coding RNA taurine‐upregulated gene 1 (lncRNA TUG1) is reported to be involved in the progression and development of several malignancies; however, its role in Philadelphia chromosome‐negative acute lymphoblastic leukemia (Ph−ALL) is unknown. The present study aimed to explore the correlation of lncRNA TUG1 with disease risk, disease condition, and prognosis of adult Ph−ALL. Methods Total 101 adult Ph− ALL patients and 40 bone marrow (BM) donors were included, followed by detection of BM monocyte cell lncRNA TUG1 expression by reverse transcription‐quantitative polymerase chain reaction. According to the quantiles of lncRNA TUG1 expression in Ph− ALL patients, these patients were divided into four tiers: tier 1 (ranked in 0%~25%), tier 2 (ranked in 25%~50%), tier 3 (ranked in 50%~75%), and tier 4 (ranked in 75%~100%). Results LncRNA TUG1 was upregulated in Ph− ALL patients compared with healthy donors. Further analysis indicated that in Ph− ALL patients, higher lncRNA TUG1 tier was correlated with the presence of central nervous system leukemia, increased white blood cell level, and bone marrow blasts. Furthermore, higher lncRNA TUG1 tier was negatively associated with complete remission (CR) within 4 weeks, total CR, and allogeneic hematopoietic stem cell transplant achievement. In addition, higher lncRNA TUG1 tier was associated with decreased disease‐free survival and overall survival, which was further verified to be an independent factor by Cox's regression analysis. Conclusion lncRNA TUG1 presents potential to be a novel biomarker for disease risk assessment and survival surveillance in Ph− ALL management.

Long noncoding RNA TUG1 upregulates VEGFA to enhance malignant behaviors in stomach adenocarcinoma by sponging miR‐29c‐3p

“… 35 , 36 TUG1 is highly expressed in several hematologic malignancies, which has been indicated to be correlated with increased disease risk and stage in multiple myeloma and acute lymphocytic leukemia. 37 , 38 It has been previously reported that the elevated levels of TUG1 usually led to a poor prognosis in STAD patients. 10 Moreover, TUG1 has been implicated in the malignant behaviors of STAD cells in vitro, and proven to participate in tumorigenesis in vivo.…”

Identification of lncRNAs associated with the progression of acute lymphoblastic leukemia using a competing endogenous RNAs network

“…Also, CRNDE promotes cancer cell proliferation, migration, and invasion and suppresses apoptosis through complicated mechanisms, that result in the initialization and development of human cancers [29]. TUG1 is significantly increased in ph-ALL compared to the control group, and its expression can be a potential prognostic biomarker in ALL [21]. It has been reported that TUG1 can activate the MAPK1/ERK pathway through the ceRNA network, which is crucial for the pathogenesis of acute myeloid leukemia [30].…”

“…Association of IRF1-AS1, MCM3AP-AS1, and TRAF3IP2-AS1 subnets to cancer progression pathways Previous studies have shown the association of HOTAIRM1, CRNDE, and TUG1 expression in the pathogenesis of various cancers, including ALL [20,21]. Hence, we decide to investigate the association of IRF1-AS1, MCM3AP-AS1, and TRAF3IP2-AS1 expression and their possible role in ALL, to which less attention has been paid.…”

Long non‐coding RNAs regulate treatment outcome in leukemia: What have we learnt recently?

“…The lncRNA CCAT2 was upregulated in the peripheral blood of CML patients and associated with therapy response, as the enhanced expression of CCAT2 at diagnosis indicates imatinib resistance in CML 73 . A higher level of lncRNA TUG1 was found to be negatively correlated with complete remission within 4 weeks, total complete remission, and allogeneic HSCT achievement in adult Ph − ALL 103 . Therefore, correlations between leukemia patient treatment outcome and lncRNA expression/function have been identified by multiple studies.…”