Correlation Analysis of Neutrophil/Albumin Ratio and Leukocyte Count/ Albumin Ratio with Ischemic Stroke Severity

Abstract

Background: Ischemic stroke (IS) is a common neurological disease in the elderly, but the relationship between neutrophil/albumin ratio (NAR) and leukocyte count/albumin ratio (LAR) and the severity of neurological function injury and early neurological deterioration (END)occurrence remain elusive in acute IS.Methods: A total of 299 patients with acute IS and 56 healthy controls were enrolled. According to the NIHSS score at admission, the disease group was divided into three groups (mild, moderate and severe IS), and the differences in ve indexes NAR, LAR, neutrophil count, leukocyte count and albumin among the four groups were analyzed. Furthermore, explore the correlation between the above indicators and the severity of IS and END occurrence.Results: The results showed that higher NAR, LAR, neutrophil count, leukocyte count levels and lower albuminlevels were associated with acute IS, and the levels of NAR and LAR increased gradually in three groups of IS. NAR and LAR were positively and albumin was negatively correlated with the severity of IS.Meanwhile, NAR and LAR showed a good predictive value in identifying patients with END after acute IS.Conclusions: NAR and LAR may be predictors of the severity of IS and END occurrence after acute IS.

Beyond diagnosis: Leveraging routine blood and urine biomarkers to predict severity and functional outcome in acute ischemic stroke

“…Studies have demonstrated that lower plasma albumin levels are associated with larger infarct volumes, higher morbidity and mortality, and poorer functional recovery in patients with AIS [ [39] , [40] , [41] ]. These findings are consistent with the present results, which highlight the importance of albumin as an essential biomarker for assessing the severity and prognosis of AIS.…”

“…One of the main functions of albumin is to maintain sufficient colloid osmotic pressure in the blood [ 42 ]. Reduced plasma albumin levels may lead to increased blood viscosity and result in inadequate cerebral blood perfusion [ 41 ]. In addition, hypoalbuminemia may lead to abnormal blood coagulation and platelet aggregation activity and thus may increase the risks of atherosclerosis and thrombosis [ [41] , [42] , [43] ].…”

“…Reduced plasma albumin levels may lead to increased blood viscosity and result in inadequate cerebral blood perfusion [ 41 ]. In addition, hypoalbuminemia may lead to abnormal blood coagulation and platelet aggregation activity and thus may increase the risks of atherosclerosis and thrombosis [ [41] , [42] , [43] ]. Furthermore, albumin is involved in the regulation of the inflammatory response; reduced plasma albumin may increase the degree of inflammatory response and worsen the severity and prognosis of stroke [ 41 , 44 ].…”

“…In addition, hypoalbuminemia may lead to abnormal blood coagulation and platelet aggregation activity and thus may increase the risks of atherosclerosis and thrombosis [ [41] , [42] , [43] ]. Furthermore, albumin is involved in the regulation of the inflammatory response; reduced plasma albumin may increase the degree of inflammatory response and worsen the severity and prognosis of stroke [ 41 , 44 ]. In patients with AIS, hypoalbuminemia may also reflect a systemic state of malnutrition, which in turn affects the severity and prognosis of stroke [ 39 , 44 ].…”

Prediction of early neurological deterioration in acute ischemic stroke patients treated with intravenous thrombolysis

“…5,6 Owing to the huge heterogeneity of definition criteria of END in previous studies, reported incidence of END also varied from 5% to 40%. 7 When END was defined as an increase in the National Institutes of Health Stroke Scale (NIHSS) scores !4 within the first 24 hours after IVT, the reported incidence rates of END after IVT were 8.1-28.1%. 8 There are some straightforward causes may lead to END, such as symptomatic intracranial hemorrhage, malignant edema, early recurrent ischemic stroke, and poststroke seizure.…”