Correlation Analysis of Ocular Symptoms and Signs in Patients with Dry Eye

Song, Haiqu; Zhang, Mingzhou; Hu, Xiao; Li, Kaixiu; Jiang, Xiaodan; Liu, Yan; Lv, Huibin; Li, Xuemin

doi:10.1155/2017/1247138

Cited by 20 publications

(15 citation statements)

References 22 publications

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“…This result was already shown in many studies and confirmed the weak correlation between signs and symptoms in DED. 31 – 33 Interestingly, in our study, the OSI was correlated with OSDI score and particularly with the ocular symptoms subscale (sensitivity to light, grittiness, pain, blurred vision, and poor vision). This result suggested that tear film instability induced aberrations and scattering, and consequently fluctuating vision that is perceived by patients.…”

Section: Discussionsupporting

confidence: 48%

Impact of Dry Eye Disease on Vision Quality: An Optical Quality Analysis System Study

Herbaut

Liang

Rabut

et al. 2018

Trans. Vis. Sci. Tech.

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PurposeWe evaluated the relationship between ocular surface clinical tests and quality of vision in patients with dry eye disease (DED).MethodsIn this study, 136 eyes of 72 dry eye patients were evaluated retrospectively using the ocular surface disease index (OSDI), measurement of tear film break-up time (TBUT), the Oxford score, Van Bijsterveld score, and Schirmer I test. Quality of vision was assessed with the optical quality analysis system (OQAS) using the objective scatter index (OSI) recorded over 20 seconds without blinking. Correlations between dry eye symptoms and signs, and OSI measurements were evaluated.ResultsThe OSI and OSI standard deviation (OSI SD) were correlated with TBUT (r = −0.21, P = 0.013 and r = −0.18, P = 0.038, respectively), Oxford score (r = 0.31, P = 0.0002 and r = 0.18, P = 0.032, respectively), and the Van Bijsterveld score (r = 0.33, P = 0.0001 and r = 0.25, P = 0.003, respectively). The OSI also was correlated with the Schirmer test (r = −0.19, P = 0.025), OSDI (r = 0.17, P = 0.04), and the ocular symptoms subscale of the OSDI (r = 0.21, P = 0.01). OSI SD was correlated with the environmental triggers subscale of the OSDI (r = 0.21, P = 0.016).ConclusionsQuality of vision measured with the OQAS was correlated with dry eye symptoms and signs. The OQAS could be a useful tool to better evaluate visual function in patients with DED.Translational RelevanceThe OQAS provides a better understanding of patient complaints about alteration of vision quality. It might be useful to integrate this objective system in severity assessments and follow-up of DED, especially for treatment evaluations.

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Section: Discussionsupporting

confidence: 48%

Impact of Dry Eye Disease on Vision Quality: An Optical Quality Analysis System Study

Herbaut

Liang

Rabut

et al. 2018

Trans. Vis. Sci. Tech.

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“…DED can be assessed based on a combination of symptoms and signs. However, several studies reported poor correlation between DED symptoms and signs [26][27][28]. Dryness symptoms could be assessed systematically using validated questionnaires that include questions allow for the monitoring of dryness symptoms and their frequency and or their severity over time [29].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associated risk factors of dry eye disease in 16 northern West bank towns in Palestine: a cross-sectional study

et al. 2020

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Background: Dry Eye Disease (DED) is a multifactorial disease of the interpalpebral ocular surface and tear film that leads to discomfort, fatigue and disturbance in vision. DED affects patients' quality of life and leads eventually to decrease of productivity. Moreover, it has a considerable socioeconomic burden. It is a growing underdiagnosed health issue and the possible associated risk factors are very common and keep growing worldwide. Purpose: To assess the prevalence of DED and potential associated risk factors in the Northern West Bank of Palestine. Methods: A cross sectional study was conducted in 16 selected towns in Northern West Bank governorates during December 2016 to September 2017. An interviewer-assisted Ocular Surface Disease Index (OSDI) questionnaire was used to study DED symptoms in the study population. Further evaluation of clinical signs of DED was performed using the following objective tests: tear film break-up time (TBUT), fluorescein corneal staining (FL/S) and Schirmer test. Subjects with an OSDI score of 13 or above were considered symptomatic of DED, and DED was defined if an OSDI score ≥ 13 is accompanied by at least one of the following signs in the worse eye: TBUT ≤10 s, Schirmer score ≤ 5 mm and fluorescein corneal staining ≥ grade 1. Results: Seven hundred sixty-nine subjects were recruited from the general non-clinical population in the West Bank. The mean age of participants was 43.61 ± 18.57 years ranging from 18 to 90 years. Females constitute 52.7% of the study population. Based on the diagnostic criteria, the prevalence of DED was 64% (95% confidence interval 60.6-67.3). DED was significantly associated with female gender p = (0.001) and older age p = (0.001). Conclusion: The prevalence of DED is high in the study population. Older age and female gender were associated risk factors with the development of DED.

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“…The procedures currently used to detect and diagnose DED can be unreliable and often do not reveal the form of DED which is occurring in the patient. As an example, the Schrimer test depend on capillary migration of tears into a filter paper, and the migration distance is used to determine the absence or presence of DED [18–19]. A short migration distance may indicate the cause is aqueous-deficient DED (ADDED), but inserting the paper strips can influence the results.…”

Section: Introductionmentioning

confidence: 99%

Contact lens to measure individual ion concentrations in tears and applications to dry eye disease

Badugu

Jeng

Reece

et al. 2018

Analytical Biochemistry

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Dry eye disease (DED) affects millions of individuals in the United States and worldwide, and the incidence is increasing with an aging population. There is widespread agreement that the measurement of total tear osmolarity is the most reliable test, but this procedure provides only the total ionic strength and does not provide the concentration of each ionic species in tears. Here, we describe an approach to determine the individual ion concentrations in tears using modern silicone hydrogel (SiHG) contact lenses. We made pH (or HO, hydronium cation,/OH, hydroxyl ion) and chloride ion (two of the important electrolytes in tear fluid) sensitive SiHG contact lenses. We attached hydrophobic C18 chains to water-soluble fluorescent probes for pH and chloride. The resulting hydrophobic ion sensitive fluorophores (H-ISF) bind strongly to SiHG lenses and could not be washed out with aqueous solutions. Both H-ISFs provide measurements which are independent of total intensity by use of wavelength-ratiometric measurements for pH or lifetime-based sensing for chloride. Our approach can be extended to fabricate a contact lens which provides measurements of the six dominant ionic species in tears. This capability will be valuable for research into the biochemical processes causing DED, which may improve the ability to diagnose the various types of DED.

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Correlation Analysis of Ocular Symptoms and Signs in Patients with Dry Eye

Cited by 20 publications

References 22 publications

Impact of Dry Eye Disease on Vision Quality: An Optical Quality Analysis System Study

Impact of Dry Eye Disease on Vision Quality: An Optical Quality Analysis System Study

Prevalence and associated risk factors of dry eye disease in 16 northern West bank towns in Palestine: a cross-sectional study

Contact lens to measure individual ion concentrations in tears and applications to dry eye disease

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