Correlation analysis of preoperative serum alpha-fetoprotein (AFP) level and prognosis of hepatocellular carcinoma (HCC) after hepatectomy

Abstract

BackgroundTo investigate the prediction value of preoperative serum alpha-fetoprotein (AFP) level for the prognosis of hepatocellular carcinoma (HCC), by comparing pathological characteristics, recurrence rate and survival rate after hepatectomy.Methods108 cases of HCC patients who received liver resection in our hospital from 2005 to 2011 were enrolled in this study. According to preoperative serum AFP level, the patients were divided into AFP ≤ 20 ng/mL group, AFP 20 to 400 ng/mL group and AFP > 400 ng/mL group, and the clinicopathological and cytopathological features were compared. All the patients were followed up for 24 months, the postoperative recurrence rates and survival rates were compared and analyzed, and the risk factors for HCC postoperative survival rate were studied by multifactor regression analysis.ResultsOf the 108 cases of HCC patients, there were 42 cases in AFP ≤20 ng/mL group, 28 cases in AFP 20–400 ng/mL group and 39 cases in AFP > 400 ng/mL group. It was shown that cell differentiation degrees (χ2 = 20.198, P = 0.000) and microvascular invasion rates (χ2 = 20.358, P = 0.000) were significantly different among the three groups. The AFP ≤ 20 ng/mL group showed higher cell differentiation degrees and significantly lower microvascular invasion rates compared to the other groups (P < 0.05). The follow-up data showed that postoperative 2-year recurrence rate (χ2 = 6.164, P = 0.046), 18-month survival rate (χ2 = 7.647, P = 0.022) and 24-month survival rate (χ2 = 6.725, P = 0.035) of the three groups were significantly different, and we found that the AFP ≤ 20 ng/mL group had lower postoperative 2-year recurrence rate, and higher 18-month survival rate and 24-month survival rate than the other two groups (P <0.05). Multiple logistic regression analysis indicated that tumor diameter (≥ 5 cm) and preoperative serum AFP level (> 400 ng/mL) were closely correlated with HCC postoperative survival rate (P <0.05).ConclusionsIt is shown that preoperative serum AFP level has considerable predictive value for the malignant feature and prognosis of HCC. It is suggested that HCC patients with no contraindication of operation and serum AFP ≤ 20 ng/mL can benefit most from primary treatment of hepatectomy. While HCC patients with serum AFP higher than 20 ng/mL need comprehensive therapy besides surgical resection and close follow up.

The Transforming Growth Factor β1/Interleukin-31 Pathway Is Upregulated in Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure and Is Associated with Disease Severity and Survival

“…Elevation of ALT usually indicates liver cell damage, while total TBil and ALB are clinical indices reflecting the extent of liver injury and liver function decompensation. AFP is a glycoprotein most commonly found in HCC patients and also exists in serum in pregnancy, active liver disease, and embryonic gonad tumors (26). We excluded pregnancy, HCC, and embryonic gonad tumors, so AFP was related to active hepatic injury in our enrolled subjects.…”

Evaluation of antiangiogenic efficacy in advanced hepatocellular carcinoma: Biomarkers and functional imaging

“…In a large Chinese retrospective cohort, high serum AFP level correlated with larger HCC size, vascular invasion and low tumor differentiation [57] . Previous studies showed that AFP levels could be useful to predict recurrence after surgery [58,59] , liver transplantation [60][61][62] . The value of AFP as a prognostic marker was reported in several studies evaluating sorafenib in advanced HCC.…”

Efficacy of Contrast-Enhanced Ultrasound Washout Rate in Predicting Hepatocellular Carcinoma Differentiation

“…Poorly differentiated tumor, large tumor size, macrovascular invasion and microvascular invasion are independent predictors of poor survival and tumor recurrence after hepatectomy and transplantation (Jun et al 2012;Ma et al 2013;Marelli et al 2008;Pawlik et al 2005;Rodriguez-Peralvarez et al 2013;Wayne et al 2002;Xu et al 2014;Zhao et al 2012). Pre-operative assessment of the differentiation grade could help in predicting prognosis, allowing appropriate patient selection for liver resection or transplant allocation.…”