Correlation Analysis of Thyroid Function and Autoantibody in Healthy Population Living in the Area of Water-Source-Originated High Level Iodine

Abstract

Abstract:In order to know about the correlation between thyroid function and autoantibody of urban residents in Cangzhou, the author chose 3218 health examinations as the respondents from Cangzhou to do a research. First of all, fasting venous blood was taken from elbow in the morning. Secondly, serum was separated by centrifugation. Moreover, the positive rates of TSH, FT3, FT4, TPOAb and TgAb in serum were tested by use of Germany Roche chemiluminescence immune detection system. It finally turns out that thyroid dysfunction and positive rate of autoantibody are 7.71% and 16.19%, respectively, which have been increasing sharply along with the growth of the age, and the positive rate of female is higher than that of the male (P <0.001). Besides, the prevalence rates of hyperthyroidism, subclinical hyperthyroidism, hypothyroidism, and subclinical hypothyroidism are 0.81%, 0.68%, 1.83% and 4.38%, respectively. The prevalence rate of subclinical thyroid disease (5.07%) is significantly higher than that of clinical thyroid disease (2.64%), and the prevalence rate of clinical hypothyroidism is the highest, accounting for 56.9% of thyroid dysfunction. Positive rates of TPOAb and TgAb are 14.57% and 12.74%, respectively, while the simultaneous positive detection rate of TPOAb and TgAb is 11.12%. Through the analysis of test data, the author comes to the conclusion that thyroid dysfunction and positive rate of autoantibody have been increasing year by year, which has a great relationship with gender and age. As a result, it is important to put the determination of thyroid function and autoantibody into the routine testing and it is necessary for normal thyroid function and positive autoantibody to conduct a dynamic monitoring, follow-up or intervention in time, which is beneficial to early diagnosis, differential diagnosis and prophylaxis and treatment.