Correlation Analysis of Vaspin Gene Polymorphisms and Polycystic Ovary Syndrome Based on Intelligent Medicine

Abstract

Polycystic ovary syndrome (PCOS) is now a common gynecological endocrine disease, also known as Stein–Leventhal syndrome. Studies have found that Vaspin gene polymorphism is significantly associated with diabetes and cardiovascular disease, and PCOS has a clear glucose metabolism abnormality. So far, because the cause of PCOS is not clear, many problems such as the etiology, diagnostic criteria, prevention, and treatment of PCOS remain unsolved. Which also makes PCOS attract the attention of academic circles. Therefore, it is urgent to clarify the pathogenesis of PCOS, in order to explore the clinical correlation between the polymorphism of the Vaspin gene and polycystic ovary syndrome. This article introduces the correlation analysis study of Vaspin gene polymorphisms and polycystic ovary syndrome based on intelligent medicine. This article first selected 40 patients with PCOS as the experimental group and then selected 40 patients without PCOS as the control group. Secondly, through the detection methods of hs-CRP level detection and oil red O fat staining and passed two sets of control experiments. Finally, intelligent medical data analysis was used to analyze the location of the Vaspin gene in the experimental group and the control group. The final result showed that the correlation reached 75%.

The Complex Roles of Adipokines in Polycystic Ovary Syndrome and Endometriosis

“…Genetic polymorphisms (SNPs) in the vaspin gene SERPINA12 were identified, which strongly correlated with vaspin serum levels with p -values up to 10 −35 , but no association with T2D or related traits were observed [ 179 ]. With regard to PCOS, in a very recent study including 40 women with PCOS and the same number of control individuals, the C allele of SNP C677T in the vaspin gene was reported to increase the risk of PCOS 2.077 times ( p < 0.05), and thus was suggested to be a genetic susceptibility marker for PCOS [ 180 ]. In a previous study including 150 women with PCOS and the same number of controls, the vaspin gene SNP rs2236242 exhibited significant differences in genotype frequencies between both groups (OR = 0.59, CI = 0.37–0.95, p = 0.03).…”

Retracted: Correlation Analysis of Vaspin Gene Polymorphisms and Polycystic Ovary Syndrome Based on Intelligent Medicine

“…Computational Intelligence and Neuroscience has retracted the article titled "Correlation Analysis of Vaspin Gene Polymorphisms and Polycystic Ovary Syndrome Based on Intelligent Medicine" [1] due to concerns that the peer review process has been compromised. Following an investigation conducted by the Hindawi Research Integrity team [2], signifcant concerns were identifed with the peer reviewers assigned to this article; the investigation has concluded that the peer review process was compromised.…”

“…Computational Intelligence and Neuroscience has retracted the article titled “Correlation Analysis of Vaspin Gene Polymorphisms and Polycystic Ovary Syndrome Based on Intelligent Medicine” [ 1 ] due to concerns that the peer review process has been compromised.…”