Correlation and interaction between urinary metals level and diabetes: A cross sectional study of community-dwelling elderly

Abstract

BackgroundIt has been reported that metal exposure is associated with the risk of diabetes, but the results are inconsistent.The relationship between diabetes and a single metal might be attenuated or strengthened due to the complex interactions of metals and the chronic diseases comorbidity (especially in the elderly). However, the evidence of multiple metal exposure effect in participants with diabetes only is limited, particularly in the elderly. The present case-control study of 188 diabetic and 376 healthy participants aimed to evaluate the potential relationships between the concentrations of 9 metals in urine and the risk of diabetes and to access the interactive effects of metals in Chinese community-dwelling elderly. MethodsThe urine levels of 9 metals (cobalt, zinc, copper, arsenic, molybdenum, cadmium, tellurium, thallium, lead) were detected by inductively coupled plasma mass spectrometry (ICP-MS) in 564 adults recruited from Yinchuan Community Health Service Center (Yinchuan, China).Logistic regression and restricted cubic spline (RCS) analysis were used to explore the associations and doseresponse relationships of urine metals with diabetes. To analysis of multi-metal exposures and diabetes risk, weighted quantile sum regression Models (WQS) and the Bayesian Kernel Machine Regression (BKMR) model were applied. ResultsThe concentrations of cobalt, zinc, copper, arsenic, molybdenum, cadmium, tellurium, thallium and lead were higher in the diabetes group (p < 0.05). In logistic regression analysis, we found that the OR values of urinary cobalt, zinc, copper, arsenic, molybdenum, cadmium, tellurium, thallium, and lead quartiles showed an increasing trend. In the single-metal model, the adjusted ORs(95%CI) in the highest quartiles were 2.

Associations between metal-metal interaction and the risk of hypertension: A case-control study in Chinese community-dwelling elderly

“…We used an inductively coupled plasma mass spectrometer(ICP-MS) (Agilent, 7800X) to measure vanadium(V), iron(Fe), cobalt(Co), zinc(Zn), copper(Cu), arsenic (As), selenium(Se), molybdenum(Mo), cadmium(Cd), tellurium(Te), thallium(Tl), lead(Pb) in the urine of the subjects. The speci c experimental steps refer to the method part of the article published by our research group (Wang et al, 2023).…”