Correlation and Prognostic Utility of B-Type Natriuretic Peptide and Its Amino-Terminal Fragment in Patients With Chronic Kidney Disease

Abstract

A b s t r a c t This study compared the correlation and prognostic utility of B-type natriuretic peptide (BNP) and the N-terminal fragment of proBNP (NT-proBNP)

Pro-B-Type Natriuretic Peptide Levels in Acute Decompensated Heart Failure

“…Research has demonstrated that metabolites of natriuretic peptides may assist in the diagnosis and treatment of this disease. Numerous studies have demonstrated that BNP and NT-proBNP are capable of predicting hospital readmission and eventual mortality in patients suffering from heart failure (9,10,(12)(13)(14)25). However, it is now apparent that the current assays for both BNP and NT-proBNP may be influenced by other circulating forms of BNP (17).…”

“…Research has suggested that NT-proBNP levels during hospitalization are strong predictors for hospital readmission and mortality (12,13). The utility of NT-proBNP in predicting subsequent cardiac events has been confirmed in patients with renal insufficiency in spite of its renal clearance (14,15). Despite the intensive investigations of BNP and NT-proBNP in heart failure patients, little data have been presented regarding other natriuretic peptide metabolites or precursor compounds.…”

BNP or NTproBNP? A clinician's perspective

“…Several other studies support the idea that the influence of renal function on plasma NTproBNP is greater than that on BNP since its clearance is predominantly renal while BNP's clearance is rather peripheral [59][60][61]. According to Kroll and Srisawasdi [33] the plasma ratio between BNP and NTproBNP is nonlinear throughout the different classes of HF.…”

Le syndrome cardiorénal : diagnostic, physiopathologie et prise en charge

“…Le dosage du BNP plasmatique permet donc d'étayer le diagnostic d'insuffisance cardiaque aiguë ou de décompensation d'insuffisance cardiaque chronique. Il conserve un intérêt en tant que facteur indépen-dant de survenue d'événements cardiovasculaires et de mortalité chez des patients insuffisants rénaux [45], bien que l'interprétation de ses variations doive être prudente chez le patient insuffisant rénal chronique car une élévation du BNP peut y être observée, même en dehors de toute surcharge hydrosodée [46]. Enfin, d'autres biomarqueurs spécifiques du stress oxydatif comme le tumor necrosis factor-α (TNFα), l'interleukine (IL)-1 et l'IL-6 semblent jouer un rôle prépon-dérant dans la physiopathologie du SCR et peuvent être recherchés de façon précoce, mais restent moins accessibles en pratique courante.…”