Correlation between adenoma detection rate and other quality indicators, and its variability depending on factors such as sedation or indication for colonoscopy

Groza, A; Ungureanu, Bogdan Silviu; Tefas, Cristian; Miuţescu, Bogdan; Tantau, Marcel

doi:10.3389/fphar.2022.1041915

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…17 Some findings even indicated that ADR and PDR may be higher with general endoscopy without anesthesia. 25 In the present study, it was found that sedated endoscopy improved the ADR, AADR and PDR, suggesting that sedation can help enhance the diagnostic ability of colonoscopy. Thus, sedation should be considered as a potential quality influencing factor.…”

Section: Discussionsupporting

confidence: 54%

Influence of Sedated Endoscopy on Colorectal Adenoma Detection Rate: A Multicenter Study

Zhou¹,

Li²,

Ji³

et al. 2023

Cancer Screen Prev

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Background and objectives: Studies on the effect of sedated endoscopy on adenoma detection rate (ADR) and advanced adenoma detection rate (AADR) remain scarce. The present study aims to determine whether sedation can help improve ADR and AADR.Methods: Colonoscopies conducted in four endoscopy centers from January 2012 to July 2019 were included to create a propensity score-matched cohort, and compare the endoscopic factors. Results:The colonoscopies of 216,400 cases were included. The ADR (32.24% vs. 31.63%, p < 0.05), AADR (5.59% vs. 5.39%, p < 0.05), and polyp (20.61% vs. 20.21%, p < 0.05) increased in the sedated endoscopy group, especially for flat adenomas (44.80% vs. 43.95%, p < 0.05) and adenomas of 0-5 mm (66.99% vs. 66.24%, p < 0.05). However, there was no significant difference, in terms of lesion site. Furthermore, the number of biopsies per colonoscopy was significantly higher in the sedated group (0.79 ± 0.93 vs. 0.56 ± 0.80, p < 0.001). Moreover, there was a significant increase in electronic (0.92% vs. 0.83%, p < 0.05) and chemical staining (0.57% vs. 0.45%, p < 0.001) in the sedated group. Conclusions:The ADR, AADR and polyp detection rate increased for sedated colonoscopy, especially for flat adenomas and adenomas of 0-5 mm. In addition, the frequency of staining, image enhancement techniques, and number of biopsies per colonoscopy increased in sedated colonoscopy.

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Section: Discussionsupporting

confidence: 54%

Influence of Sedated Endoscopy on Colorectal Adenoma Detection Rate: A Multicenter Study

Zhou¹,

Li²,

Ji³

et al. 2023

Cancer Screen Prev

View full text Add to dashboard Cite

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Sedated Colonoscopy may not be Beneficial for Polyp/Adenoma Detection

Han,

Cao,

et al. 2024

Cancer Control

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Background Sedated colonoscopy has been increasingly selected. However, the effect of sedated colonoscopy on polyp/adenoma detection rate (PDR/ADR) remains controversial among studies. Methods In this retrospective study, the medical records of 11 504 consecutive patients who underwent colonoscopy at our department from July 1, 2021 to December 31, 2022 were collected. Patients were divided into sedated and unsedated groups according to the use of intravenous sedation during colonoscopy. Overall PDR/ADR, right-side, transverse, and left-side colon PDR/ADR, and single and multiple PDR/ADR were calculated. By adjusting for age, gender, body mass index, inpatient, screening/surveillance, cecal intubation time, colonoscopy withdrawal time ≥6 min, and an endoscopist’s experience ≥5 years, multivariate logistic regression analyses were performed to evaluate the association of sedated colonoscopy with overall PDR/ADR, right-side, transverse, and left-side colon PDR/ADR, and single and multiple PDR/ADR, where the absence of PDR/ADR was used as reference. Odds ratios (ORs) with their 95% confidence intervals (CIs) were calculated. Results Overall, 2275 patients were included, of whom 293 and 1982 underwent sedated and unsedated colonoscopy, respectively. Multivariate logistic regression analyses showed that sedated colonoscopy was independently associated with lower overall PDR/ADR (OR = 0.640, 95% CI = 0.460-0.889, P = 0.008), right-side colon PDR/ADR (OR = 0.591, 95% CI = 0.417-0.837, P = 0.003), single PDR/ADR (OR = 0.659, 95% CI = 0.436-0.996, P = 0.048), and multiple PDR/ADR (OR = 0.586, 95% CI = 0.402-0.855, P = 0.005), but not transverse or left-side colon PDR/ADR. Conclusion Sedated colonoscopy may not be beneficial in terms of overall PDR/ADR, right-side colon PDR/ADR, and number of polyps/adenomas. Thus, it should be selectively recommended. Additionally, it should be necessary to explore how to improve the quality of sedated colonoscopy.

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Correlation between adenoma detection rate and other quality indicators, and its variability depending on factors such as sedation or indication for colonoscopy

Cited by 2 publications

References 12 publications

Influence of Sedated Endoscopy on Colorectal Adenoma Detection Rate: A Multicenter Study

Influence of Sedated Endoscopy on Colorectal Adenoma Detection Rate: A Multicenter Study

Sedated Colonoscopy may not be Beneficial for Polyp/Adenoma Detection

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