Correlation Between Age, Body Mass Index, And Blood Selenium Level with Glutathione Peroxidase Activity Among Elderly in South Jakarta

Kirana, Annisa Nurul; Prafiantini, Erfi; Hardiany, Novi Silvia

doi:10.31344/ijhhs.v4i2.181

Cited by 2 publications

(1 citation statement)

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“…10,11 Selenium was an important trace element due to as a component of antioxidants enzymes (selenoproteins), including glutathione peroxidase for protection against free radical.There was no correlation between blood selenium level and plasma glutathione peroxidase activity. 12 When free radical production increases or the system of culling is not effective, there will be a buildup of free radicals, oxidative stress arises. Increased levels of MDA that are not offset by the amount of antioxidant GSH that is formed will cause hepatocyte damage.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Jatropha Curcas L Seed Extract in Oxidatve Stress and Central Vein of Liver Tissue

Nurbaeti

Hapsari

Wulandari

2020

Int. J. Hum. Health Sci.

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Introduction:Jatropha curcas L is a tropical plant, besides containing antioxidants it also contains toxic compounds. This plant is believed to be anti-inflammatory, antimicrobial, antibacterial and antifertilization. It is suspected that this plant can damage tissues through oxidative stress. The liver as an organ of central metabolism and detoxification. This plant is not yet known its effect on the liver when consumed, especially on hepatocyte cells and blood flow to the central veins of the liver.Method: Mice were given a dose of jatropha seed extract (0, 5, 25, 50, 250 mg/KgBW) for 28 days. Liver homogenates were measured for MDA levels, GSH activity and their correlation using a spectrophotometry. besides measuring the diameter of the central vein of the liver. Results: MDA levels after being given Jatropha seed extract: control (0); 5; 25; 50; 250 mg/KgBW were 0.818; 1,363; 2,043; 2,720; 2,518 nmol / ml and GSH activity was 0.979; 0675; 0.621; 0.463; 0.544 μg / ml. Vein diameter 169; 140; 24; 36; 30 μm and the smallest at a dose of 25 mg / BW was 23.7 μm (ANOVA, p <0.05). The correlation of MDA and GSH levels was very strong negative (Pearson: -0918; p <0.01). Discussion:The higher dose of jatropha seed extract, significantly increases MDA levels and decreases GSH activity. The correlation between the two is very strong negative negative correlation is very significant. Jatropha seed extract with high doses causes small central vein diameters of the liver.International Journal of Human and Health Sciences Vol. 05 No. 01 January’21 Page: 41-46

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Section: Introductionmentioning

confidence: 99%