Correlation between alanine aminotransferase level, HCV-RNA titer and fibrosis stage in chronic HCV genotype 4 infection

Swaff, Reham Al

doi:10.1016/j.ejmhg.2012.03.001

Cited by 10 publications

(7 citation statements)

References 29 publications

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“…Al Swaff (20) have found an association between grade 1 and grade 4 liver fibrosis and higher ALT levels in patients with CHC (genotype 4) infection and have detected higher HCV RNA levels in grade 3 liver fibrosis.…”

Section: Discussionmentioning

confidence: 98%

The Relationship Between the Serum RNA Titers of Hepatitis C Virus and Biochemical Parameters in Chronic Hepatitis C Patients

Nar¹,

Sezgin²

2016

vhd

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ÖZObjective: Liver biopsy, as well as some non-invasive biochemical parameters are also used in monitoring patients with chronic hepatitis C (CHC). The aim of this study was to investigate the relationship between serum biochemical markers and HCV RNA titers in patients with previously untreated CHC. Materials and Methods:We performed a retrospective study on anti-HCV and HCV-RNA-positive 82 patients with CHC. Eighty two healthy subjects constituted the control group. Complete blood counts, total protein (TP), albumin (ALB), C-reactive protein (CRP), γ-glutamyl transpeptidase (GGT), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and HCV RNA levels were recorded for each patient and control subject. Neutrophil-lymphocytes ratio (NLR) and the fibrosis index based on the 4 factors (FIB-4 index) were calculated using formulas.Results: There was a significant difference in ALT, AST, GGT, TP , CRP , red cell distribution width (RDW), lymphocytes (LYM), platelets (PLT), FIB-4, and NLR between CHC patients and controls (p=<0.05

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Section: Discussionmentioning

confidence: 98%

The Relationship Between the Serum RNA Titers of Hepatitis C Virus and Biochemical Parameters in Chronic Hepatitis C Patients

Nar¹,

Sezgin²

2016

vhd

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“…In contrast, grades of activity were independent of serum HCV-RNA titer. Also she found that patients with stages 1 and 4 hepatic fibrosis had significantly higher levels of ALT than patients with other stages of hepatic fibrosis [7]. These conflicting results could be attributed to the differences in HCV genotypes and the ethnicity of the population studied.…”

Section: Discussionmentioning

confidence: 98%

“…Egypt has the highest prevalence of HCV worldwide (15%) [4] and the highest prevalence of HCV genotype 4, which are responsible for almost 90% of HCV infections [5]. Patients infected with hepatitis C virus (HCV) have different clinical outcomes, ranging from acute resolving hepatitis to chronic liver disease including liver cirrhosis or hepatocellular carcinoma [6], hence the need for suitable and reliable investigations to predict the severity of liver injury caused by HCV infection [7].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Liver Function Tests and Polymerase Chain Reaction in Chronic Hepatitis C Patients

Aka¹,

As²,

Ah³

et al. 2015

J Hepatol Gastroint Dis

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Background: Hepatitis C virus infection is currently the most significant public health problem globally and particularly in Egypt. The outcomes of HCV infection range from asymptomatic chronic infection, with normal or nearly normal liver functions, to severe chronic hepatitis, evolving rapidly to cirrhosis and hepatocellular carcinoma. Our objective is to asses and evaluates the relationship between liver function tests, serum HCV-RNA positivity and the severity of liver damage in chronic HCV patients. Method: We studied 329 patients with chronic HCV, they were categorized into two groups according to the PCR results: first group were positive PCR (86 %), and second group were negative PCR (14 %). Liver transaminases, total and direct bilirubin, serum albumin, HCV RNA detection and viral load by real time PCR, and liver biopsy were done to all patients. Results: This study showed that the liver transaminases were significantly higher in HCV positive patients than in HCV negative patients (p value <0.0001). We also observed that the comparison between positive PCR group with negative PCR group revealed that, there were no statistically significant difference regarding albumin, alkaline phosphate, total bilirubin , direct bilirubin and prothrombin (p=0.35, p=0.80, p=0.26, p=0.86 and p=0.99 respectively). Conclusions: high results of liver function tests may be indicator for the severity of liver damage in chronic HCV patients but also PCR should be done as some cases show normal results while its PCR was high. There is no relationship between liver function tests and the grade of activity or fibrosis.

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“…The association between serum ALT and liver damage is unclear; therefore, the degree of liver damage is evaluated through liver biopsy 14 . The patients, who have persistent normal levels of ALT, are considered to be affected with mild degree of histological hepatic damage.…”

Section: Reactivation Of Virusmentioning

confidence: 99%

Liver Enzymes Correlation among Chronic Hepatitis C Patients with Virus Infection Fibrosis Progression

et al. 2018

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Correlation between alanine aminotransferase level, HCV-RNA titer and fibrosis stage in chronic HCV genotype 4 infection

Cited by 10 publications

References 29 publications

The Relationship Between the Serum RNA Titers of Hepatitis C Virus and Biochemical Parameters in Chronic Hepatitis C Patients

The Relationship Between the Serum RNA Titers of Hepatitis C Virus and Biochemical Parameters in Chronic Hepatitis C Patients

Correlation between Liver Function Tests and Polymerase Chain Reaction in Chronic Hepatitis C Patients

Liver Enzymes Correlation among Chronic Hepatitis C Patients with Virus Infection Fibrosis Progression

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