Correlation between angiopoietin-2 and layered plaques in patients with acute coronary syndrome

Abstract

Objective Through a retrospective analysis of patients diagnosed with Acute coronary syndrome (ACS), relationships between Angiopoietin-2 (Ang2) and Optical coherence tomography (OCT) were investigated, especially in layered plaque. Methods In the analysis of patients’OCT image with ACS before operation, a total of 101 patients and 107 target vessels participated. Moreover, patients were divided into layered plaque (LP) group and non-layered plaque (NLP) group in accordance with whether target lesions of the patients had a layered plaque. Furthermore, Ang2 concentration was determined by ELISA. Binary Logistic regression model was employed to determine relationship between Ang2 and layered plaques, and ability of Ang2 to predict layered plaques as target lesions of ACS was determined by Receiver Operating Characteristic(ROC)curve. Results Between LP and NLP groups, there were substantial differences in Ang2 concentration. Besides, results of univariate and multivariate analysis indicated that Ang2 was an independent risk factor for layered plaques. Except for that, ROC illustrated that AUC of Ang2 level for predicting layered plaques, and optimum cut-off value was determined by Jorden index (15.045ng/mL). Conclusions In comparison with NLP groups, Ang2 levels in patients with ACS in the LP group were substantially higher than those in the NLP group. Other than that, concentration of Ang2 emerged as a standalone predictor for layered plaques.