Correlation between anthropometric parameters and acute skin toxicity in breast cancer radiotherapy patients: a pilot assessment study

Méry, Benoîte; Vallard, Alexis; Trone, Jane‐Chloé; Pacaut, Cécile; Guy, Jean‐Baptiste; Espenel, Sophie; Langrand-Escure, Julien; Ollier, Édouard; Wang, Guoping; Diao, Peng; Bigot, Lise; Ndong, Sylvie Mengue; Bosacki, Claire; Mrad, Majed Ben; Magné, Nicolas

doi:10.1259/bjr.20150414

Cited by 14 publications

(13 citation statements)

References 27 publications

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“…Despite our limited number of patients, our results agree with previous reports of the predisposing factors of acute radiation dermatitis. Increased breast volume young age and dark phototype were associated with more severe skin toxicity, as we found on univariate analysis. The phototype was not associated with the severity of the clinical score of acute radiation dermatitis in a recent series, but patients with clear phototypes were overrepresented in this series as 97% had phototypes 1‐3 and only 3% had phototype 4, with no patients with phototypes 5 or 6, whereas 8/34 patients in our series had phototypes 4 or 5 …”

Section: Discussionsupporting

confidence: 79%

“…The severity of acute radiation dermatitis has decreased with the progression in radiation technology. However, our study, and others, demonstrates that nearly all patients are concerned with mild or more severe acute reactions. Late complications of acute radiation dermatitis are associated with the occurrence and severity of the disease and are chronic and sometimes severe.…”

Section: Discussionsupporting

confidence: 42%

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High‐frequency ultrasound quantification of acute radiation dermatitis: pilot study of patients undergoing radiotherapy for breast cancer

Garnier

Champeaux

Laurent

et al. 2017

Skin Research and Technology

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Section: Discussionsupporting

confidence: 79%

Section: Discussionsupporting

confidence: 42%

High‐frequency ultrasound quantification of acute radiation dermatitis: pilot study of patients undergoing radiotherapy for breast cancer

Garnier

Champeaux

Laurent

et al. 2017

Skin Research and Technology

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“… 20 , 21 One study described a standardised and reproducible protocol to measure breast size (the thickness of left and right axillary fat and nipple-to-pectoral muscle distance), finding that anthropometric measurements correlate with the risk of skin toxicity. 16 …”

Section: Resultsmentioning

confidence: 99%

“…6 , 7 , 10 , 11 , 12 , 13 , 14 The observed normal tissue toxicity rates and breast cosmetic outcome depend on treatment and patient-related factors such as the type and number of surgical procedures, systemic treatment, breast size and shape, race, age, comorbidities, smoking, individual sensitivity to ionizing radiation, choice of fractionation and radiation dose, skin bolus, inter-fraction time interval, volume irradiated, and radiotherapy delivery modality. 15 It is a widely accepted fact that patient-related factors, such as higher body mass index (BMI) and larger breasts 7 , 10 , 16 increase the risk of ≥ grade 2 (G2) dermatitis, regardless of the fractionation regimen. 11 , 17 …”

Section: Introductionmentioning

confidence: 99%

Breast size impact on adjuvant radiotherapy adverse effects and dose parameters in treatment planning

Ratoša

Jenko

Oblak

2018

Radiology and Oncology

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BackgroundBreast radiotherapy is an established adjuvant treatment after breast conserving surgery. One of the important individual factors affecting the final cosmetic outcome after radiation is breast size. The purpose of this review is to summarise the clinical toxicity profile of adjuvant radiotherapy in women with breasts of various sizes, and to evaluate the treatment planning studies comparing target coverage and dose to thoracic organs at risk in relation to breast size.ConclusionsInhomogeneity and excessive radiation dose (hot spots) in the planning of target volume as well as large volume of the breast per se, all contribute to a higher rate of acute adverse events and suboptimal final cosmetic outcome in adjuvant breast cancer radiotherapy, regardless of the fractionation schedule. Improved homogeneity leads to a lower rate of ≥ grade 2 toxicity and can be achieved with three-dimensional conformal or modulated radiotherapy techniques. There may be an association between body habitus (higher body mass index, bigger breast size, pendulous breast, and large chest wall separation) and a higher mean dose to the ipsilateral lung and whole heart. A combination of the technical innovations (i.e. the breath-hold technique, prone position with or without holding breath, lateral decubitus position, and thermoplastic bra), dose prescription (i.e. moderate hypofractionation), and irradiated volume (i.e. partial breast irradiation) should be tailored to every single patient in clinical practice to mitigate the risk of radiation adverse effects.

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“…These parameters are some of the variables that have been more frequently related to skin toxicity. 40 Concern could also arise from the ad-hoc cosmetic questionnaire, which was not previously validated.…”

Section: Discussionmentioning

confidence: 99%

Patients’ view of the differences in topical creams for radiation dermatitis prevention. A pilot study of cosmetic properties

Sabater

Leon

Esteban

et al. 2019

Reports of Practical Oncology & Radiotherapy

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Aim: To investigate the feasibility of including patients' reports on the cosmetic properties of topical formulations for acute radiation dermatitis (ARD). Background: No topical agent tested for acute radiation dermatitis (ARD) has proven to be better than any other, all achieving similar objective outcomes. No clear guidelines have therefore been established in clinics. Because the vehicle for such creams has shown to be an important factor in patient adherence to treatments in other dermatological diseases, patients' opinions are evaluated. Material and methods: Seventy breast cancer patients referred for postoperative radiotherapy after conservative surgery were enrolled. Patients were assigned to use one of the 7 topical agents that are most-commonly used in the prevention of ARD. Patients' reports were assessed using continuous visual analogue scales (VAS), objective signs and symptoms produced by ARD, and were rated using the RTOG and RISRAS scales. Results: The creams tested differed in their cosmetic properties significantly (p = 0.044). The performance of the agent, their absorption and any residue left over were also significantly different (p = 0.022, 0.014 and 0.02, respectively). Conclusions: Topical agents for preventive ARD are reported by patients to show different cosmetic properties. Cosmetic properties are important when choosing topical agents for ARD prevention. Recommending those with better cosmetic profiles would improve patient adherence to treatments.

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Correlation between anthropometric parameters and acute skin toxicity in breast cancer radiotherapy patients: a pilot assessment study

Abstract: The present article analyses several characteristics and anthropomorphic measurements of breast in order to assess breast size. A standardized and reproducible protocol to measure breast volume is described.

Cited by 14 publications

References 27 publications

High‐frequency ultrasound quantification of acute radiation dermatitis: pilot study of patients undergoing radiotherapy for breast cancer

High‐frequency ultrasound quantification of acute radiation dermatitis: pilot study of patients undergoing radiotherapy for breast cancer

Breast size impact on adjuvant radiotherapy adverse effects and dose parameters in treatment planning

Patients’ view of the differences in topical creams for radiation dermatitis prevention. A pilot study of cosmetic properties

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