Correlation Between Anti-Dsdna, Complement Components C3, C4 and Systemeic Lupus Erythematosus Disease Activity Index

Abstract

Anti-dsDNA antibodies were the first autoantibodies described in patients with SLE. Anti-dsDNA antibodies can be found in up to 70% to 80% of patients with SLE at some time during the course of the disease, these antibodies are very rarely found in patients with other autoimmune conditions and in healthy controls. Furthermore, in many cases there is a relationship between disease activity and the titer of anti-dsDNA. In a larger study, Swaak showed that rise in levels of anti-dsDNA antibodies preceded renal flares in SLE (3) and subsequent independent studies also showed that rises in anti-ds DNA antibody level were associated with flares of activity, either in the kidney or in other organ.

Platelet count as inflammatory marker in pediatric Systemic Lupus Erythematosus

“…Farkhati et al 22 stated that in SLE patients with positive anti-dsDNA levels, severe disease activity was present and they had higher mortality rate. Another study from Dhason et al 23 revealed that anti-dsDNA antibody level was positive in 83% of all patients with active lupus and 66% of them had high titre of anti-dsDNA levels (>10 IU/ml). There was also a significant correlation between high anti-dsDNA titre and disease activity in the active disease group compared to inactive disease and healthy controls in their study (P<0.001).…”

Correlation between Lymphocyte Level and Disease Activity in Systemic Lupus Erythematosus Patients

“…The level of C3 and C4 in serum are used as indicators of complement consumption in SLE because activation of the complement occurs during the course of active disease, so lower levels of complement indicate a higher level of disease activity in SLE. 4 Lymphopenia is a common clinical manifestation in systemic lupus erythematosus (SLE) and is one of the diagnostic criteria. 9 Lymphopenia was observed in 62% of adult patients at the diagnosis of SLE.…”

“…2 There are various method to quantify disease activity, identify flares and to predict flares. 2,4 Serological tests are commonly used to assess the disease activity and predict lupus flare including complement (C3 and C4) test. 2,4,5 During active disease, usually there is a fall in complement levels.…”

“…2,4 Serological tests are commonly used to assess the disease activity and predict lupus flare including complement (C3 and C4) test. 2,4,5 During active disease, usually there is a fall in complement levels. 2,5 However this tools are limited and require high cost.…”

A Retrospective Study on Antinuclear Antibody Patterns in Systemic Lupus Erythematosus Patients and Its Correlation With Serological Markers

“…Systemic lupus erythematosus (SLE) is a systemic chronic inflammatory autoimmune disorder that affects multiple organs. It predominantly affects women, with a female-to-male ratio of 6-12:1 and a peak incidence during the reproductive age span [ 1 , 2 ]. One of the challenging aspects of SLE is the wide spectrum of clinical manifestations due to multisystem involvement and the progressive nature of the disease.…”